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Q6NRW0 (MTBP_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mdm2-binding protein
Gene names
Name:mtbp
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length860 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation By similarity.

Sequence similarities

Belongs to the MTBP family.

Ontologies

Keywords
   Biological processCell cycle
Growth arrest
Ubl conjugation pathway
Gene Ontology (GO)
   Biological processcell cycle arrest

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 860860Mdm2-binding protein
PRO_0000323747

Sequences

Sequence LengthMass (Da)Tools
Q6NRW0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 279019BF58BDDBEE

FASTA86096,308
        10         20         30         40         50         60 
MERFVLCIHW ERRAEQQQPV PQGLVYAQDI YTQLKEYSTN CTSTFPACSL TGNPGIRKWF 

        70         80         90        100        110        120 
FALQSLYGFS QFCSSDWEDL CPAVTTDDSE EPVQTALDEC LDALQFPDGE DDNSRDSISQ 

       130        140        150        160        170        180 
TNLFEEAAEL LHQLSDKLPA PGRALVDVLL FPSEAPKLKD CLSAIGAIKH LKEWHTAKIT 

       190        200        210        220        230        240 
IVSKDCKGWQ KIGKFLSANV VVSDCPRQLI DPQELWRGTI EIKERKFTSE VEFPEFCLRS 

       250        260        270        280        290        300 
VSDDKVPYFE NNGDDKNKTV LSEVFHYYGA SLEYVQMVAL SEIPSYFVSD SVFELSITRN 

       310        320        330        340        350        360 
GLQGKSKLML DQLCSLTEKV GAIFMLPCNV CSLPNPPALQ RSSKKWREYM SRKPKDIKVP 

       370        380        390        400        410        420 
GVELKGEYCS YYFLIQGKGS GLCKATLLHS ASQISGAASL LLLHQRLNNN HPVNMAESTS 

       430        440        450        460        470        480 
DILDSLPHFN GEQIALREQI LARAQVLAVK EYLKRQEAQP HASVSQSNNL GRLLALTREH 

       490        500        510        520        530        540 
VIGDCESRLD SVSYKNMQNI TVSTPAFPES EAMISNPADW PERNVLQNLE NFEKIKQRLR 

       550        560        570        580        590        600 
ASILSGSAEQ LLGRKDGLKE GMTLLDAKEL LKYFTPQGLA VGELQPLQVQ RGDNAFLVTP 

       610        620        630        640        650        660 
KLTPRKLKGL PFEKAAECHY HGLEYCLDNR KALDRDVAFS ELQSRLIRYE TQTTCTRECC 

       670        680        690        700        710        720 
PIPFALSPIP SPAVLSEPGS VPDGESIQTE LRGDPLRLKR RSKDIEGLYP SKRLAKSGSS 

       730        740        750        760        770        780 
DSLVSLASEG SGHQQPTRLR TERTASSVSG AQPSSTRVRT APSVPAQSKP SSHLELEQKE 

       790        800        810        820        830        840 
SRSQKHNRML KEVVSKTLQK HSIGVEHPCY AACNQRLFEI SKFFLKDLKT SRGLLDEMKK 

       850        860 
AASNNAKQVI QWELDKLKKN

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC070600 mRNA. Translation: AAH70600.1.
RefSeqNP_001084870.1. NM_001091401.1.
UniGeneXl.5551.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID431919.
KEGGxla:431919.

Organism-specific databases

CTD27085.
XenbaseXB-GENE-990926. mtbp.

Phylogenomic databases

HOVERGENHBG108152.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameMTBP_XENLA
AccessionPrimary (citable) accession number: Q6NRW0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: June 28, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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