Q6NRT6 (DJC10_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 10

Gene names

Name:

dnajc10

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	796 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane By similarity.
Subcellular location	Secreted Potential. Endoplasmic reticulum lumen By similarity.
Sequence similarities	Contains 1 J domain. Contains 4 thioredoxin domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Secreted
Domain	Repeat Signal
Molecular function	Chaperone
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 796	763	DnaJ homolog subfamily C member 10		PRO_0000281487
Regions
	Domain	36 – 100	65	J
	Domain	131 – 233	103	Thioredoxin 1
	Domain	455 – 554	100	Thioredoxin 2
	Domain	558 – 668	111	Thioredoxin 3
	Domain	672 – 780	109	Thioredoxin 4
	Motif	793 – 796	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	531	1	N-linked (GlcNAc...) Potential
	Glycosylation	753	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6NRT6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F3AB8453C8397F37	FASTA	796	90,984
	10 20 30 40 50 60 MKHSLNTATS SSSVLKRTIL YLVLISLAAL VYCDDDYYDL LGVSKAATNR EIRQAFKKLA 70 80 90 100 110 120 LKLHPDKNKD PDAHNKFLKI NRAYEVLKDE DLRKKYDKYG EKGLDEQNQG GGYQSWSYYR 130 140 150 160 170 180 YDFGIYDDDL EIITLDRGEF DGAVNSGELW FINFYSPGCS HCHDLAPTWR QFAKEMDGLL 190 200 210 220 230 240 RIGAVNCGDN RMLCRSQGIN SYPNLYIFKS GMNPVKYYGE RSKERLVNFA MPYISSTVTE 250 260 270 280 290 300 LWAGNFRSSI EDAFSSGVGW LITFCSDTGD CLNSQTRSKL AGLLEGLVKV GWMDCATQGD 310 320 330 340 350 360 LCDNLEITSS ATVYFPPGST LTDKENGDVL FLNSLDAREI YKEVLNHLPD LETISPESLQ 370 380 390 400 410 420 GKLSHHRWLL FFTFGTDEQS SLPEFKKLTV HLRSEHVQVG KFDCYSSPSI CSELYIHKPC 430 440 450 460 470 480 VAAFKGKGIS AYEIHHGKVQ LYDLVSFAKE SVNSHVITLG PTNFPGKDRD TWLVDFFAPW 490 500 510 520 530 540 CPPCRALLPE LRIASKRLFG QIKFGTLDCT IHEGLCNMHN IRAYPTTVVF NHSNIHEYAG 550 560 570 580 590 600 HNNAEEILEF IEDLRNPSVV TLTPETFQSL VRNRRGDEMW MVDFYAPWCG PCQALMPEWK 610 620 630 640 650 660 RMARHINGLI SVGSIDCQKY SLFCTQERVN GYPEIRLYPA NINPQHTYYR YTGWHRDSQS 670 680 690 700 710 720 LRNWALMYLP KASFDLTPES FHEHVINGKD NWVLDFYAPW CGPCQNFNPE FEILARAVKG 730 740 750 760 770 780 KIKAGKVNCQ AYEHLCNSAS IRSYPTVRLY PYNGSKKKDY FGEQIDSRDA KEIAQIITKR 790 IEAIKRVKEA YNKDEL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC070632 mRNA. Translation: AAH70632.1.
RefSeq	NP_001084933.1. NM_001091464.1.
UniGene	Xl.47147.
3D structure databases
ProteinModelPortal	Q6NRT6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	431990.
KEGG	xla:431990.
Organism-specific databases
CTD	54431.
Xenbase	XB-GENE-981000. dnajc10.
Phylogenomic databases
HOVERGEN	HBG057048.
KO	K09530.
Family and domain databases
Gene3D	1.10.287.110. 1 hit. 3.40.30.10. 4 hits.
InterPro	IPR001623. DnaJ_domain. IPR021170. DnaJ_homolog_subfam-C. IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view]
Pfam	PF00226. DnaJ. 1 hit. PF00085. Thioredoxin. 4 hits. [Graphical view]
PIRSF	PIRSF037293. DnaJ_homolog_subfam-C. 1 hit.
PRINTS	PR00625. JDOMAIN. PR00421. THIOREDOXIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit. SSF52833. Thiordxn-like_fd. 6 hits.
PROSITE	PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 3 hits. PS51352. THIOREDOXIN_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DJC10_XENLA

Accession

Primary (citable) accession number: Q6NRT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program