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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

ssu72

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Gene namesi
Name:ssu72
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5725684. ssu72.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly in the cytosol.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300171 – 194RNA polymerase II subunit A C-terminal domain phosphatase SSU72Add BLAST194

Structurei

3D structure databases

ProteinModelPortaliQ6NRQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili160 – 186Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG059831.
KOiK15544.

Family and domain databases

InterProiView protein in InterPro
IPR006811. RNA_pol_II_suA.
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiView protein in Pfam
PF04722. Ssu72. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NRQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTAPLRVAV VCSSNQNRSM EAHNILSKRS FNVRSFGTGT HVKLPGPAPD
60 70 80 90 100
KPNVYDFKTT YEQMYSDLLK KDKELYTQNG ILHMLDRNRR IKPRPERFQN
110 120 130 140 150
CKDYFDLVIT CEERVYDQVV EELNSREQET CQPVHVINVD IQDNHEEATL
160 170 180 190
GAFLICELCQ CIQHTEDMEN EIDELLQEFE DKSGRTFLHT ICFY
Length:194
Mass (Da):22,681
Last modified:July 5, 2004 - v1
Checksum:i92B269CB832A2EC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31F → I in AAH98966 (Ref. 1) Curated1
Sequence conflicti91I → V in AAH98966 (Ref. 1) Curated1
Sequence conflicti178E → D in AAH98966 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070675 mRNA. Translation: AAH70675.1.
BC098966 mRNA. Translation: AAH98966.1.
RefSeqiNP_001084864.1. NM_001091395.1.
NP_001089572.1. NM_001096103.1.
UniGeneiXl.48475.
Xl.9702.

Genome annotation databases

GeneIDi431913.
734628.
KEGGixla:431913.
xla:734628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070675 mRNA. Translation: AAH70675.1.
BC098966 mRNA. Translation: AAH98966.1.
RefSeqiNP_001084864.1. NM_001091395.1.
NP_001089572.1. NM_001096103.1.
UniGeneiXl.48475.
Xl.9702.

3D structure databases

ProteinModelPortaliQ6NRQ7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi431913.
734628.
KEGGixla:431913.
xla:734628.

Organism-specific databases

CTDi431913.
734628.
XenbaseiXB-GENE-5725684. ssu72.

Phylogenomic databases

HOVERGENiHBG059831.
KOiK15544.

Family and domain databases

InterProiView protein in InterPro
IPR006811. RNA_pol_II_suA.
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiView protein in Pfam
PF04722. Ssu72. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSU72_XENLA
AccessioniPrimary (citable) accession number: Q6NRQ7
Secondary accession number(s): Q4KLW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: January 18, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.