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Protein

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

Gene

b3galnt2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation (By similarity).By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl-(1->4)-O-alpha-D-mannosylprotein = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-alpha-D-mannosylprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (EC:2.4.1.-)
Short name:
Beta-1,3-GalNAc-T2
Alternative name(s):
Beta-1,3-N-acetylgalactosaminyltransferase II
Gene namesi
Name:b3galnt2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1012161. b3galnt2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini32 – 486455LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2PRO_0000248365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6NRQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080884.
KOiK09654.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NRQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLFLCPC VIGVAFHLWL FNFSGLFSWF LVWSPHSYDI VVGVLSARHN
60 70 80 90 100
HELRNVIRHT WLQHLNHHSS LSQRVLVKFI IGSHGCDIPV EDREDPYSCK
110 120 130 140 150
LLNITNPTLK QEIESFSIPD SAAVITEHHV VNVNFRVLYP VVITRLGVFQ
160 170 180 190 200
HDSAAGFQRN ITVKLFQTEH EEALFSARFS PASSGVQVNG IWYKPVEQFI
210 220 230 240 250
LPEGFEGTVV WESHDPEGLL SGNVHHVIVN DGGGIFRLTT VKEGLLPYEF
260 270 280 290 300
TEGVEGIAGG FTYTIHEGET LLNTLETRPE RIQNHLAALE KEDALLQEES
310 320 330 340 350
TTFQDIVFVN VVDTYRNVPS KLLNFYRWTV QLTRFEFLLK TDDDCFIDID
360 370 380 390 400
NVLKMVAQKE LQKENAWWGN FRLNWAVDRT GKWQELEYLS PAYPAFACGS
410 420 430 440 450
GYIISNDIVQ WLAVNSQRLK TYQGEDVSMG IWMSAIGPSR YQDSRWLCEK
460 470 480
KCEAGMLSSP QYTPQELMEI WQQKERCGNP CACEDR
Length:486
Mass (Da):55,701
Last modified:July 5, 2004 - v1
Checksum:i412B4D46BCCF29BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070684 mRNA. Translation: AAH70684.1.
RefSeqiNP_001084830.1. NM_001091361.1.
UniGeneiXl.47816.

Genome annotation databases

GeneIDi431874.
KEGGixla:431874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070684 mRNA. Translation: AAH70684.1.
RefSeqiNP_001084830.1. NM_001091361.1.
UniGeneiXl.47816.

3D structure databases

ProteinModelPortaliQ6NRQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi431874.
KEGGixla:431874.

Organism-specific databases

CTDi148789.
XenbaseiXB-GENE-1012161. b3galnt2.

Phylogenomic databases

HOVERGENiHBG080884.
KOiK09654.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiB3GL2_XENLA
AccessioniPrimary (citable) accession number: Q6NRQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.