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Protein

Sorting nexin-33

Gene

snx33

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-33
Alternative name(s):
SH3 and PX domain-containing protein 3
Gene namesi
Name:snx33
Synonyms:sh3px3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-955371. snx33.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119501 – 550Sorting nexin-33Add BLAST550

Structurei

3D structure databases

ProteinModelPortaliQ6NRL2.
SMRiQ6NRL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini206 – 316PXPROSITE-ProRule annotationAdd BLAST111
Domaini347 – 550BARAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 102Asp-richAdd BLAST16

Domaini

The PX and BAR domains mediate association with membranes and are required for membrane tubulation.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOVERGENiHBG009996.
KOiK17923.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR001683. Phox.
IPR001452. SH3_domain.
IPR028642. SNX33.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
PANTHERiPTHR10555:SF175. PTHR10555:SF175. 1 hit.
PfamiView protein in Pfam
PF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
PIRSFiPIRSF027744. Snx9. 2 hits.
SMARTiView protein in SMART
SM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NRL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKARALYS FQGENKEEIN LMENEELQLL SDVSLDGWLQ GTNSRGQTGL
60 70 80 90 100
FPASYVEIQS SRSGSVQVDY SGNAREYTDP PHQGSYDDDD EEDDDDWDDW
110 120 130 140 150
DDGQTVVDEP SGSNGVSRSE LQHHHHYSRP EYSHRPRPAL ERQDSIASGK
160 170 180 190 200
RGSVVGRNLN RFSSFVRSGV EAFVLGDVPQ FGGVAESHAI EMAPKGPQWK
210 220 230 240 250
ANPRPFNCSV EEPTKQTKFK GIKSYISYRL TPDHSNSPVY RRYKHFDWLY
260 270 280 290 300
NRLLHKFTVI SLPHLPEKQA TGRFEEDFIQ KRKRRLVLWM DHMTSHPVLS
310 320 330 340 350
QYDGFQHFLG CQDEKQWKAG KRRAERDELV GASFLLTLQL PTEHQDLQDV
360 370 380 390 400
EERVDVFKAF SKKMDESVLQ LSSVVSELAR KHLGGFRKEF QKLGAAFQGL
410 420 430 440 450
SHSFQLDPPY SSEPLVGAIS HTGRTYEAVG EMFAEQPKND QFRFLDTLSL
460 470 480 490 500
YQGLLSNFPD IIHLQKGAFA KVKDSQRMSD EGRMEQDEAD GVRKRCRVVG
510 520 530 540 550
FALQAEINHF HQRRLLDFKQ AIQHYLKEQI IFYRRVSQEL EKTLHLYDEL
Length:550
Mass (Da):63,323
Last modified:July 5, 2004 - v1
Checksum:i0E323681395CAA5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070737 mRNA. Translation: AAH70737.1.
RefSeqiNP_001084772.1. NM_001091303.1.
XP_018109698.1. XM_018254209.1.
XP_018109699.1. XM_018254210.1.
UniGeneiXl.29278.

Genome annotation databases

GeneIDi431808.
KEGGixla:431808.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSNX33_XENLA
AccessioniPrimary (citable) accession number: Q6NRL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families