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Protein

NADPH-dependent diflavin oxidoreductase 1

Gene

ndor1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of ciapin1.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • FMNUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321FMNUniRule annotation
Binding sitei354 – 3541FADUniRule annotation
Binding sitei463 – 4631NADPUniRule annotation
Binding sitei599 – 5991FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176FMNUniRule annotation
Nucleotide bindingi59 – 624FMNUniRule annotation
Nucleotide bindingi97 – 10610FMNUniRule annotation
Nucleotide bindingi386 – 3894FADUniRule annotation
Nucleotide bindingi420 – 4234FADUniRule annotation
Nucleotide bindingi518 – 5192NADPUniRule annotation
Nucleotide bindingi524 – 5285NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent diflavin oxidoreductase 1UniRule annotation (EC:1.18.1.-UniRule annotation)
Alternative name(s):
NADPH-dependent FMN and FAD-containing oxidoreductaseUniRule annotation
Gene namesi
Name:ndor1UniRule annotation
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251781. ndor1.

Subcellular locationi

  • Cytoplasmperinuclear region UniRule annotation

  • Note: Concentrated in perinuclear structure.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600NADPH-dependent diflavin oxidoreductase 1PRO_0000319542Add
BLAST

Interactioni

Subunit structurei

Interacts with ciapin1. Interacts with dcps.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NRG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 150145Flavodoxin-likeUniRule annotationAdd
BLAST
Domaini210 – 449240FAD-binding FR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
Contains 1 FAD-binding FR-type domain.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG104950.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
HAMAPiMF_03178. NDOR1.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_dom.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR028879. NDOR1.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NRG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQQNLLILY GSQTGTAEDL AGRLSREAKR HHFNCRTEAL DEYRVANLIN
60 70 80 90 100
EHLVIFVCAT TGQGDPPDNM KNFWRFIFRR NLPHNALCQM DYAVLGLGDS
110 120 130 140 150
SYPKFNFIAK KLHKRLNQLG ACPLLPAALG DDQHELGPDA VVDPWLKDLW
160 170 180 190 200
SKVLSMFPLR PGLEIISEDV LLPPKYSLRL LEEKVGQSEL SGDAYERDFI
210 220 230 240 250
SNNTTPPSEI HPFLAPVLSN ERVSAHDHFQ DVRLIEFNIT GSAIQFYPGD
260 270 280 290 300
VVMVQPRNSL LHVEQFCSLL HLDPLNKVVV EPSDPESPVP MHLAALCSVQ
310 320 330 340 350
QLVERYLDIC SIPRRSFFQL FCHFSPDEME REKLKEFSCA AGQEELYSYC
360 370 380 390 400
NRPRRTILEV LVDFPHTTRC IPATFLLELI PQIRPRAFSI ASSMEALPNT
410 420 430 440 450
IQILMAVVQY KTKLIEPRRG LCSTWLASLP PHGTERVPIW VKKGSMKFPC
460 470 480 490 500
DPDTPVVMVG PGTGVAPFRA AIQERVANGR PGNCLFFGCR GKSKDFYFEK
510 520 530 540 550
EWEDLGNRGY LTLFTAFSRD QEDKIYVQHR IKENSKLLWD LIGTKQGYVY
560 570 580 590 600
IAGNAKLMPN EVTDALKWVL QLEGGMSAPD AEQYLASMEK SCRFQSETWS
Length:600
Mass (Da):68,077
Last modified:July 5, 2004 - v1
Checksum:i449FC3604F637F54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070785 mRNA. Translation: AAH70785.1.
RefSeqiNP_001084766.1. NM_001091297.1.
UniGeneiXl.28148.

Genome annotation databases

GeneIDi431801.
KEGGixla:431801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070785 mRNA. Translation: AAH70785.1.
RefSeqiNP_001084766.1. NM_001091297.1.
UniGeneiXl.28148.

3D structure databases

ProteinModelPortaliQ6NRG5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi431801.
KEGGixla:431801.

Organism-specific databases

CTDi27158.
XenbaseiXB-GENE-6251781. ndor1.

Phylogenomic databases

HOVERGENiHBG104950.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
HAMAPiMF_03178. NDOR1.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_dom.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR028879. NDOR1.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiNDOR1_XENLA
AccessioniPrimary (citable) accession number: Q6NRG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: January 20, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.