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Q6NRE8 (SUV91_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SUV39H1
EC=2.1.1.43
Alternative name(s):
Suppressor of variegation 3-9 homolog 1
Short name=Su(var)3-9 homolog 1
Gene names
Name:suv39h1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome › centromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.

Sequence similarities

Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 chromo domain.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Histone-lysine N-methyltransferase SUV39H1
PRO_0000281812

Regions

Domain46 – 10459Chromo
Domain189 – 24961Pre-SET
Domain251 – 379129SET
Domain405 – 42117Post-SET

Sequences

Sequence LengthMass (Da)Tools
Q6NRE8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 776BD7633D03C069

FASTA42148,581
        10         20         30         40         50         60 
MAENSNGALG CVVRCLSSES ELQELCREEQ LCCAELGVTR KNLSDFEVEY LWNYKKVQDQ 

        70         80         90        100        110        120 
ELYLVKWKYY PDSESTWEPR HHLKCNNLLK QFHLDLEREL LRRAKAAGTK KTAVRCPRRL 

       130        140        150        160        170        180 
DQSLSHYLVL KAKQRKRLRQ WAQQLNAKRS HLGLILVENE VDLEGPPRDF VYINEYRVGE 

       190        200        210        220        230        240 
GVTINRISAG CKCRDCFSDE GGCCPGAFQH KKAYNNEGQV KVKPGFPIYE CNSCCRCGPS 

       250        260        270        280        290        300 
CPNRVVQKGI QYKFCIFRTS DGRGWGVRTL EKIRKNSFVM EYVGEIITSE EAERRGQIYD 

       310        320        330        340        350        360 
RQGTTYLFDL DYVEDVYTVD AARYGNISHF VNHSCKPNLQ VYNVFIDNLD ERLPRIAFFA 

       370        380        390        400        410        420 
TRTIRTGEEL TFDYNMQVDP VDVESSKMDS NFGIAGLPAS PKKRVRVECK CGVSSCRKYL 


F

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC070805 mRNA. Translation: AAH70805.1.
RefSeqNP_001084892.1. NM_001091423.1.
UniGeneXl.46583.

3D structure databases

ProteinModelPortalQ6NRE8.
SMRQ6NRE8. Positions 125-420.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID431943.
KEGGxla:431943.

Organism-specific databases

CTD6839.
XenbaseXB-GENE-6049313. suv39h1.

Phylogenomic databases

HOVERGENHBG055621.
KOK11419.

Family and domain databases

InterProIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFPIRSF009343. SUV39_SET. 1 hit.
SMARTSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF54160. Chromodomain-like. 1 hit.
PROSITEPS00598. CHROMO_1. False negative.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUV91_XENLA
AccessionPrimary (citable) accession number: Q6NRE8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: May 29, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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