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Q6NRE7

- CBLBB_XENLA

UniProt

Q6NRE7 - CBLBB_XENLA

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Protein

E3 ubiquitin-protein ligase CBL-B-B

Gene

cblb-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei299 – 2991PhosphotyrosineBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi232 – 24514PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 42540RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ligase activity Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro
  4. ubiquitin-protein transferase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. immune system process Source: UniProtKB-KW
  3. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Immunity, Ubl conjugation pathway

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBL-B-B (EC:6.3.2.-)
Alternative name(s):
SH3-binding protein CBL-B-B
Signal transduction protein CBL-B-B
Gene namesi
Name:cblb-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251770. cblb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764E3 ubiquitin-protein ligase CBL-B-BPRO_0000055864Add
BLAST

Interactioni

Subunit structurei

Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6NRE7.
SMRiQ6NRE7. Positions 48-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 356309Cbl-PTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 1801334HAdd
BLAST
Regioni181 – 25373EF-hand-likeAdd
BLAST
Regioni254 – 356103SH2-likeAdd
BLAST
Regioni357 – 38529LinkerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi489 – 57890Pro-richAdd
BLAST
Compositional biasi684 – 6874Poly-Pro

Domaini

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

Sequence similaritiesi

Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri386 – 42540RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG005255.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NRE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSSSSSSN SSTSSSALSG RLPGARSANP RKARILGLFD AIQDAVGPPK
60 70 80 90 100
QAAADRRTVE KTWKLMDKVV RLCQNPKLQL KNSPPYILDI LPDTYQHLRL
110 120 130 140 150
ILSKYDDNQK LAQLSENEYF KIYIDSLMKK SKRAIRLFKE GKERMYEEQS
160 170 180 190 200
QERRNLTKLS LIFSHMLAEI KAIFPSGQFQ GDTFRITKAD AAEFWRKFFG
210 220 230 240 250
ERTIVPWKIF RQCLHEVQQI SSGLEAMALK STIDLTCNDY ISVFEFDIFA
260 270 280 290 300
RLFQPWSSIL RNWNFLAVTH PGYMAFLTYD EVKARLQKYS LKHGSYIFRL
310 320 330 340 350
SCTRLGQWAI GYVTAGGNIL QTIPHNKPLF QALIDGSREG FYLYPDGRSY
360 370 380 390 400
NPDLTDLCEP TPHDHIKVTQ EQYELYCEMG STFQLCKICA ENDKDVKIEP
410 420 430 440 450
CGHLMCTSCL TSWQESDGQG CPFCRCEIKG TEPIIVDPFD PRDENRCCSF
460 470 480 490 500
NDSLCTPMFD FDDDDLREEC LIMNRLASLR KMNERQNSPV TSPGSSPLLQ
510 520 530 540 550
RRKTPPDPVQ IPHLNLPPVP PRLDLIQRGL ARSPCASPTG SPKSSPCMAR
560 570 580 590 600
KQDKPLPAPP PPLREPPPPP ERPPPIPPDS RTCRHLHHAE NVPCRDQSTP
610 620 630 640 650
NEAWCTRDLS GGNQPSVCRV THDGSPKLGV SSSVLNGRHS RVSTEAGFMR
660 670 680 690 700
HKHHKRRESP LETHRVYNGL SGNEEYDVPP RLSPPPPTIT IHPTVICPLL
710 720 730 740 750
ANSASDKVRN SAEEDDSEYK IPSSHPVSSR LPLHCHSIKH FPRLCENGQC
760
LSNGAHNGIS EIKN
Length:764
Mass (Da):86,210
Last modified:July 5, 2004 - v1
Checksum:i4FFD300CEE119F76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070806 mRNA. Translation: AAH70806.1.
RefSeqiNP_001084790.1. NM_001091321.1.
UniGeneiXl.47173.

Genome annotation databases

GeneIDi431829.
KEGGixla:431829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070806 mRNA. Translation: AAH70806.1 .
RefSeqi NP_001084790.1. NM_001091321.1.
UniGenei Xl.47173.

3D structure databases

ProteinModelPortali Q6NRE7.
SMRi Q6NRE7. Positions 48-439.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 431829.
KEGGi xla:431829.

Organism-specific databases

CTDi 431829.
Xenbasei XB-GENE-6251770. cblb.

Phylogenomic databases

HOVERGENi HBG005255.
KOi K04707.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiCBLBB_XENLA
AccessioniPrimary (citable) accession number: Q6NRE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has one functional calcium-binding site.By similarity

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3