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Q6NRE7

- CBLBB_XENLA

UniProt

Q6NRE7 - CBLBB_XENLA

Protein

E3 ubiquitin-protein ligase CBL-B-B

Gene

cblb-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei299 – 2991PhosphotyrosineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi232 – 24514PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri386 – 42540RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. ligase activity Source: UniProtKB-KW
    3. signal transducer activity Source: InterPro
    4. ubiquitin-protein transferase activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: InterPro
    2. immune system process Source: UniProtKB-KW
    3. regulation of signaling Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Immunity, Ubl conjugation pathway

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase CBL-B-B (EC:6.3.2.-)
    Alternative name(s):
    SH3-binding protein CBL-B-B
    Signal transduction protein CBL-B-B
    Gene namesi
    Name:cblb-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6251770. cblb.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764E3 ubiquitin-protein ligase CBL-B-BPRO_0000055864Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NRE7.
    SMRiQ6NRE7. Positions 48-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 356309Cbl-PTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni48 – 1801334HAdd
    BLAST
    Regioni181 – 25373EF-hand-likeAdd
    BLAST
    Regioni254 – 356103SH2-likeAdd
    BLAST
    Regioni357 – 38529LinkerAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi489 – 57890Pro-richAdd
    BLAST
    Compositional biasi684 – 6874Poly-Pro

    Domaini

    The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
    The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

    Sequence similaritiesi

    Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri386 – 42540RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG005255.
    KOiK04707.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.20.930.20. 1 hit.
    3.30.40.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR024162. Adaptor_Cbl.
    IPR014741. Adaptor_Cbl_EF_hand-like.
    IPR003153. Adaptor_Cbl_N_hlx.
    IPR014742. Adaptor_Cbl_SH2-like.
    IPR024159. Cbl_PTB.
    IPR011992. EF-hand-dom_pair.
    IPR000980. SH2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PANTHERiPTHR23007. PTHR23007. 1 hit.
    PfamiPF02262. Cbl_N. 1 hit.
    PF02761. Cbl_N2. 1 hit.
    PF02762. Cbl_N3. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47668. SSF47668. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS51506. CBL_PTB. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NRE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSSSSSSN SSTSSSALSG RLPGARSANP RKARILGLFD AIQDAVGPPK    50
    QAAADRRTVE KTWKLMDKVV RLCQNPKLQL KNSPPYILDI LPDTYQHLRL 100
    ILSKYDDNQK LAQLSENEYF KIYIDSLMKK SKRAIRLFKE GKERMYEEQS 150
    QERRNLTKLS LIFSHMLAEI KAIFPSGQFQ GDTFRITKAD AAEFWRKFFG 200
    ERTIVPWKIF RQCLHEVQQI SSGLEAMALK STIDLTCNDY ISVFEFDIFA 250
    RLFQPWSSIL RNWNFLAVTH PGYMAFLTYD EVKARLQKYS LKHGSYIFRL 300
    SCTRLGQWAI GYVTAGGNIL QTIPHNKPLF QALIDGSREG FYLYPDGRSY 350
    NPDLTDLCEP TPHDHIKVTQ EQYELYCEMG STFQLCKICA ENDKDVKIEP 400
    CGHLMCTSCL TSWQESDGQG CPFCRCEIKG TEPIIVDPFD PRDENRCCSF 450
    NDSLCTPMFD FDDDDLREEC LIMNRLASLR KMNERQNSPV TSPGSSPLLQ 500
    RRKTPPDPVQ IPHLNLPPVP PRLDLIQRGL ARSPCASPTG SPKSSPCMAR 550
    KQDKPLPAPP PPLREPPPPP ERPPPIPPDS RTCRHLHHAE NVPCRDQSTP 600
    NEAWCTRDLS GGNQPSVCRV THDGSPKLGV SSSVLNGRHS RVSTEAGFMR 650
    HKHHKRRESP LETHRVYNGL SGNEEYDVPP RLSPPPPTIT IHPTVICPLL 700
    ANSASDKVRN SAEEDDSEYK IPSSHPVSSR LPLHCHSIKH FPRLCENGQC 750
    LSNGAHNGIS EIKN 764
    Length:764
    Mass (Da):86,210
    Last modified:July 5, 2004 - v1
    Checksum:i4FFD300CEE119F76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070806 mRNA. Translation: AAH70806.1.
    RefSeqiNP_001084790.1. NM_001091321.1.
    UniGeneiXl.47173.

    Genome annotation databases

    GeneIDi431829.
    KEGGixla:431829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070806 mRNA. Translation: AAH70806.1 .
    RefSeqi NP_001084790.1. NM_001091321.1.
    UniGenei Xl.47173.

    3D structure databases

    ProteinModelPortali Q6NRE7.
    SMRi Q6NRE7. Positions 48-439.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 431829.
    KEGGi xla:431829.

    Organism-specific databases

    CTDi 431829.
    Xenbasei XB-GENE-6251770. cblb.

    Phylogenomic databases

    HOVERGENi HBG005255.
    KOi K04707.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.20.930.20. 1 hit.
    3.30.40.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR024162. Adaptor_Cbl.
    IPR014741. Adaptor_Cbl_EF_hand-like.
    IPR003153. Adaptor_Cbl_N_hlx.
    IPR014742. Adaptor_Cbl_SH2-like.
    IPR024159. Cbl_PTB.
    IPR011992. EF-hand-dom_pair.
    IPR000980. SH2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    PANTHERi PTHR23007. PTHR23007. 1 hit.
    Pfami PF02262. Cbl_N. 1 hit.
    PF02761. Cbl_N2. 1 hit.
    PF02762. Cbl_N3. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47668. SSF47668. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS51506. CBL_PTB. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Oocyte.

    Entry informationi

    Entry nameiCBLBB_XENLA
    AccessioniPrimary (citable) accession number: Q6NRE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein has one functional calcium-binding site.By similarity

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3