SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6NRE7

- CBLBB_XENLA

UniProt

Q6NRE7 - CBLBB_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
E3 ubiquitin-protein ligase CBL-B-B
Gene
cblb-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei299 – 2991Phosphotyrosine By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi232 – 24514 By similarity
Add
BLAST
Zinc fingeri386 – 42540RING-type
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ligase activity Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro
  4. ubiquitin-protein transferase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. immune system process Source: UniProtKB-KW
  3. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Immunity, Ubl conjugation pathway

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBL-B-B (EC:6.3.2.-)
Alternative name(s):
SH3-binding protein CBL-B-B
Signal transduction protein CBL-B-B
Gene namesi
Name:cblb-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251770. cblb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764E3 ubiquitin-protein ligase CBL-B-B
PRO_0000055864Add
BLAST

Interactioni

Subunit structurei

Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6NRE7.
SMRiQ6NRE7. Positions 48-439.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 356309Cbl-PTB
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 1801334H
Add
BLAST
Regioni181 – 25373EF-hand-like
Add
BLAST
Regioni254 – 356103SH2-like
Add
BLAST
Regioni357 – 38529Linker
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi489 – 57890Pro-rich
Add
BLAST
Compositional biasi684 – 6874Poly-Pro

Domaini

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG005255.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NRE7-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSSSSSN SSTSSSALSG RLPGARSANP RKARILGLFD AIQDAVGPPK    50
QAAADRRTVE KTWKLMDKVV RLCQNPKLQL KNSPPYILDI LPDTYQHLRL 100
ILSKYDDNQK LAQLSENEYF KIYIDSLMKK SKRAIRLFKE GKERMYEEQS 150
QERRNLTKLS LIFSHMLAEI KAIFPSGQFQ GDTFRITKAD AAEFWRKFFG 200
ERTIVPWKIF RQCLHEVQQI SSGLEAMALK STIDLTCNDY ISVFEFDIFA 250
RLFQPWSSIL RNWNFLAVTH PGYMAFLTYD EVKARLQKYS LKHGSYIFRL 300
SCTRLGQWAI GYVTAGGNIL QTIPHNKPLF QALIDGSREG FYLYPDGRSY 350
NPDLTDLCEP TPHDHIKVTQ EQYELYCEMG STFQLCKICA ENDKDVKIEP 400
CGHLMCTSCL TSWQESDGQG CPFCRCEIKG TEPIIVDPFD PRDENRCCSF 450
NDSLCTPMFD FDDDDLREEC LIMNRLASLR KMNERQNSPV TSPGSSPLLQ 500
RRKTPPDPVQ IPHLNLPPVP PRLDLIQRGL ARSPCASPTG SPKSSPCMAR 550
KQDKPLPAPP PPLREPPPPP ERPPPIPPDS RTCRHLHHAE NVPCRDQSTP 600
NEAWCTRDLS GGNQPSVCRV THDGSPKLGV SSSVLNGRHS RVSTEAGFMR 650
HKHHKRRESP LETHRVYNGL SGNEEYDVPP RLSPPPPTIT IHPTVICPLL 700
ANSASDKVRN SAEEDDSEYK IPSSHPVSSR LPLHCHSIKH FPRLCENGQC 750
LSNGAHNGIS EIKN 764
Length:764
Mass (Da):86,210
Last modified:July 5, 2004 - v1
Checksum:i4FFD300CEE119F76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070806 mRNA. Translation: AAH70806.1.
RefSeqiNP_001084790.1. NM_001091321.1.
UniGeneiXl.47173.

Genome annotation databases

GeneIDi431829.
KEGGixla:431829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070806 mRNA. Translation: AAH70806.1 .
RefSeqi NP_001084790.1. NM_001091321.1.
UniGenei Xl.47173.

3D structure databases

ProteinModelPortali Q6NRE7.
SMRi Q6NRE7. Positions 48-439.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 431829.
KEGGi xla:431829.

Organism-specific databases

CTDi 431829.
Xenbasei XB-GENE-6251770. cblb.

Phylogenomic databases

HOVERGENi HBG005255.
KOi K04707.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiCBLBB_XENLA
AccessioniPrimary (citable) accession number: Q6NRE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has one functional calcium-binding site By similarity.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi