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Q6NRE7 (CBLBB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase CBL-B-B

EC=6.3.2.-
Alternative name(s):
SH3-binding protein CBL-B-B
Signal transduction protein CBL-B-B
Gene names
Name:cblb-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length764 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins By similarity.

Subcellular location

Cytoplasm By similarity.

Domain

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.

Miscellaneous

This protein has one functional calcium-binding site By similarity.

Sequence similarities

Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.

Contains 1 RING-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 764764E3 ubiquitin-protein ligase CBL-B-B
PRO_0000055864

Regions

Domain48 – 356309Cbl-PTB
Calcium binding232 – 24514 By similarity
Zinc finger386 – 42540RING-type
Region48 – 1801334H
Region181 – 25373EF-hand-like
Region254 – 356103SH2-like
Region357 – 38529Linker
Compositional bias489 – 57890Pro-rich
Compositional bias684 – 6874Poly-Pro

Sites

Binding site2991Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NRE7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4FFD300CEE119F76

FASTA76486,210
        10         20         30         40         50         60 
MASSSSSSSN SSTSSSALSG RLPGARSANP RKARILGLFD AIQDAVGPPK QAAADRRTVE 

        70         80         90        100        110        120 
KTWKLMDKVV RLCQNPKLQL KNSPPYILDI LPDTYQHLRL ILSKYDDNQK LAQLSENEYF 

       130        140        150        160        170        180 
KIYIDSLMKK SKRAIRLFKE GKERMYEEQS QERRNLTKLS LIFSHMLAEI KAIFPSGQFQ 

       190        200        210        220        230        240 
GDTFRITKAD AAEFWRKFFG ERTIVPWKIF RQCLHEVQQI SSGLEAMALK STIDLTCNDY 

       250        260        270        280        290        300 
ISVFEFDIFA RLFQPWSSIL RNWNFLAVTH PGYMAFLTYD EVKARLQKYS LKHGSYIFRL 

       310        320        330        340        350        360 
SCTRLGQWAI GYVTAGGNIL QTIPHNKPLF QALIDGSREG FYLYPDGRSY NPDLTDLCEP 

       370        380        390        400        410        420 
TPHDHIKVTQ EQYELYCEMG STFQLCKICA ENDKDVKIEP CGHLMCTSCL TSWQESDGQG 

       430        440        450        460        470        480 
CPFCRCEIKG TEPIIVDPFD PRDENRCCSF NDSLCTPMFD FDDDDLREEC LIMNRLASLR 

       490        500        510        520        530        540 
KMNERQNSPV TSPGSSPLLQ RRKTPPDPVQ IPHLNLPPVP PRLDLIQRGL ARSPCASPTG 

       550        560        570        580        590        600 
SPKSSPCMAR KQDKPLPAPP PPLREPPPPP ERPPPIPPDS RTCRHLHHAE NVPCRDQSTP 

       610        620        630        640        650        660 
NEAWCTRDLS GGNQPSVCRV THDGSPKLGV SSSVLNGRHS RVSTEAGFMR HKHHKRRESP 

       670        680        690        700        710        720 
LETHRVYNGL SGNEEYDVPP RLSPPPPTIT IHPTVICPLL ANSASDKVRN SAEEDDSEYK 

       730        740        750        760 
IPSSHPVSSR LPLHCHSIKH FPRLCENGQC LSNGAHNGIS EIKN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC070806 mRNA. Translation: AAH70806.1.
RefSeqNP_001084790.1. NM_001091321.1.
UniGeneXl.47173.

3D structure databases

ProteinModelPortalQ6NRE7.
SMRQ6NRE7. Positions 48-439.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID431829.
KEGGxla:431829.

Organism-specific databases

CTD431829.
XenbaseXB-GENE-6251770. cblb.

Phylogenomic databases

HOVERGENHBG005255.
KOK04707.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERPTHR23007. PTHR23007. 1 hit.
PfamPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBLBB_XENLA
AccessionPrimary (citable) accession number: Q6NRE7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways