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Q6NQA8

- APY5_ARATH

UniProt

Q6NQA8 - APY5_ARATH

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Protein

Probable apyrase 5

Gene

APY5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.By similarity

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Calcium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei196 – 1961Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 8311ATP-bindingCuratedAdd
BLAST
Nucleotide bindingi220 – 23011ATP-bindingCuratedAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G14250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apyrase 5 (EC:3.6.1.5)
Short name:
AtAPY5
Alternative name(s):
ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase
Short name:
ADPase
NTPDase
Nucleoside triphosphate diphosphohydrolase 5
Gene namesi
Name:APY5
Ordered Locus Names:At1g14250
ORF Names:F14L17.1, F7A19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G14250.

Subcellular locationi

Membrane By similarity; Single-pass type II membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Probable apyrase 5PRO_0000420343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6NQA8.
PRIDEiQ6NQA8.

Expressioni

Tissue specificityi

Highly expressed in young rosette leaves but only weakly in roots.1 Publication

Inductioni

By wounding and drought stress.1 Publication

Gene expression databases

GenevestigatoriQ6NQA8.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G14250.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ6NQA8.
SMRiQ6NQA8. Positions 68-479.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini54 – 488435ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000077482.
InParanoidiQ6NQA8.
KOiK01510.
OMAiGKENCAY.
PhylomeDBiQ6NQA8.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NQA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDALKVQILP DNQSSPSSTH MLTKPKSKKA TKSIAMLIVA SLAITLGLLF
60 70 80 90 100
VFSSNSVMFS ASFLRRSSLH YSVIIDAGSS GTRIHVFGYW FESGKPVFDF
110 120 130 140 150
GEEHYASLKL SPGLSSYADN PEGASVSVTK LVEFAKGRIP KGKLKKSDIR
160 170 180 190 200
LMATAGMRLL DVPVQEQILD VTRRVLRSSG FKFQDEWATV ISGTDEGIYA
210 220 230 240 250
WVVANHALGS LGGDPLKTTG IVELGGASAQ VTFVPSEHVP PEFSRTISYG
260 270 280 290 300
NVSYTIYSHS FLDFGQDAAE DKLLESLQNS VAASTGDGIV EDPCTPKGYI
310 320 330 340 350
YDTHSQKDSS GFLSEESKFK ASLQVQAAGD FTKCRSATLA MLQEGKENCA
360 370 380 390 400
YKHCSIGSTF TPNIQGSFLA TENFFHTSKF FGLGEKEWLS EMILAGKRFC
410 420 430 440 450
GEEWSKLKEK YPTTKDKYLH RYCFSSAYII SMLHDSLGVA LDDERIKYAS
460 470 480
KAGKENIPLD WALGAFILNT DTPTSDYNGK SRKMIGFK
Length:488
Mass (Da):53,505
Last modified:July 5, 2004 - v1
Checksum:i75D5ED11E61F786A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF830010 mRNA. Translation: AEJ38086.1.
AC007576 Genomic DNA. No translation available.
AC012188 Genomic DNA. Translation: AAF43924.1.
CP002684 Genomic DNA. Translation: AEE29131.1.
BT010550 mRNA. Translation: AAQ65173.1.
AK175135 mRNA. Translation: BAD42898.1.
AK175519 mRNA. Translation: BAD43282.1.
PIRiE86276.
RefSeqiNP_172877.1. NM_101291.2.
UniGeneiAt.41981.

Genome annotation databases

EnsemblPlantsiAT1G14250.1; AT1G14250.1; AT1G14250.
GeneIDi837986.
KEGGiath:AT1G14250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF830010 mRNA. Translation: AEJ38086.1 .
AC007576 Genomic DNA. No translation available.
AC012188 Genomic DNA. Translation: AAF43924.1 .
CP002684 Genomic DNA. Translation: AEE29131.1 .
BT010550 mRNA. Translation: AAQ65173.1 .
AK175135 mRNA. Translation: BAD42898.1 .
AK175519 mRNA. Translation: BAD43282.1 .
PIRi E86276.
RefSeqi NP_172877.1. NM_101291.2.
UniGenei At.41981.

3D structure databases

ProteinModelPortali Q6NQA8.
SMRi Q6NQA8. Positions 68-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G14250.1-P.

Proteomic databases

PaxDbi Q6NQA8.
PRIDEi Q6NQA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G14250.1 ; AT1G14250.1 ; AT1G14250 .
GeneIDi 837986.
KEGGi ath:AT1G14250.

Organism-specific databases

GeneFarmi 3050. 285.
TAIRi AT1G14250.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000077482.
InParanoidi Q6NQA8.
KOi K01510.
OMAi GKENCAY.
PhylomeDBi Q6NQA8.

Enzyme and pathway databases

BioCyci ARA:AT1G14250-MONOMER.

Gene expression databases

Genevestigatori Q6NQA8.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analyses of Arabidopsis apyrases 3 through 7."
    Yang J.
    Thesis (2011), University of Texas, United States
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiAPY5_ARATH
AccessioniPrimary (citable) accession number: Q6NQA8
Secondary accession number(s): Q9M9T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3