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Protein

LysM domain-containing GPI-anchored protein 2

Gene

LYM3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example).1 Publication

GO - Molecular functioni

  • peptidoglycan binding Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • immune response Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
LysM domain-containing GPI-anchored protein 2
Gene namesi
Name:LYM3
Ordered Locus Names:At1g77630
ORF Names:T5M16.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G77630.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: TAIR
  • anchored component of plasma membrane Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired sensitivity to peptidoglycans (PGNs) leading to higher susceptibility to infection with virulent Pseudomonas syringae pv. tomato DC3000.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000025212325 – 394LysM domain-containing GPI-anchored protein 2Add BLAST370
PropeptideiPRO_0000252124395 – 423Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi238N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Lipidationi394GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6NPN4.
PRIDEiQ6NPN4.

Expressioni

Gene expression databases

GenevisibleiQ6NPN4. AT.

Interactioni

Subunit structurei

Interacts with peptidoglycans.1 Publication

Protein-protein interaction databases

STRINGi3702.AT1G77630.1.

Structurei

3D structure databases

ProteinModelPortaliQ6NPN4.
SMRiQ6NPN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 154LysM 1PROSITE-ProRule annotationAdd BLAST48
Domaini173 – 216LysM 2PROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Contains 2 LysM domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410II8Y. Eukaryota.
ENOG410YAMN. LUCA.
HOGENOMiHOG000083326.
InParanoidiQ6NPN4.
OMAiMYCEPAS.
OrthoDBiEOG09360D4P.
PhylomeDBiQ6NPN4.

Family and domain databases

CDDicd00118. LysM. 2 hits.
Gene3Di3.10.350.10. 2 hits.
InterProiIPR018392. LysM_dom.
[Graphical view]
PfamiPF01476. LysM. 2 hits.
[Graphical view]
SMARTiSM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NPN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNPEKPLLL FLILASSLAS MATAKSTIEP CSSKDTCNSL LGYTLYTDLK
60 70 80 90 100
VTEVASLFQV DPVSMLLSNS IDISYPDVEN HVLPAKLFLK IPITCSCVDG
110 120 130 140 150
IRKSLSTHYK TRTSDTLGSI ADSVYGGLVS PEQIQVANSE TDLSVLDVGT
160 170 180 190 200
KLVIPLPCAC FNGTDESLPA LYLSYVVRGI DTMAGIAKRF STSVTDLTNV
210 220 230 240 250
NAMGAPDINP GDILAVPLLA CSSNFPKYAT DYGLIIPNGS YALTAGHCVQ
260 270 280 290 300
CSCVLGSRSM YCEPASISVS CSSMRCRNSN FMLGNITSQQ SSSGCKLTTC
310 320 330 340 350
SYNGFASGTI LTTLSMSLQP RCPGPQQLAP LIAPPDNVPK ELMYLPSPSP
360 370 380 390 400
SPSPEFDDIA GGGSSIAAVP AASPGGATVS SSNSIPGNPA NGPGGSISIA
410 420
SCPLSYYSFI ALLIPIGSCF FVF
Length:423
Mass (Da):44,152
Last modified:July 5, 2004 - v1
Checksum:iB067C6FEBD5ED6D0
GO

Sequence cautioni

The sequence AAG51658 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010704 Genomic DNA. Translation: AAG51658.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36002.1.
BT010885 mRNA. Translation: AAR24663.1.
AK176769 mRNA. Translation: BAD44532.1.
PIRiH96805.
RefSeqiNP_177886.2. NM_106411.4.
UniGeneiAt.24354.

Genome annotation databases

EnsemblPlantsiAT1G77630.1; AT1G77630.1; AT1G77630.
GeneIDi844098.
GrameneiAT1G77630.1; AT1G77630.1; AT1G77630.
KEGGiath:AT1G77630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010704 Genomic DNA. Translation: AAG51658.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36002.1.
BT010885 mRNA. Translation: AAR24663.1.
AK176769 mRNA. Translation: BAD44532.1.
PIRiH96805.
RefSeqiNP_177886.2. NM_106411.4.
UniGeneiAt.24354.

3D structure databases

ProteinModelPortaliQ6NPN4.
SMRiQ6NPN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G77630.1.

Proteomic databases

PaxDbiQ6NPN4.
PRIDEiQ6NPN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G77630.1; AT1G77630.1; AT1G77630.
GeneIDi844098.
GrameneiAT1G77630.1; AT1G77630.1; AT1G77630.
KEGGiath:AT1G77630.

Organism-specific databases

TAIRiAT1G77630.

Phylogenomic databases

eggNOGiENOG410II8Y. Eukaryota.
ENOG410YAMN. LUCA.
HOGENOMiHOG000083326.
InParanoidiQ6NPN4.
OMAiMYCEPAS.
OrthoDBiEOG09360D4P.
PhylomeDBiQ6NPN4.

Miscellaneous databases

PROiQ6NPN4.

Gene expression databases

GenevisibleiQ6NPN4. AT.

Family and domain databases

CDDicd00118. LysM. 2 hits.
Gene3Di3.10.350.10. 2 hits.
InterProiIPR018392. LysM_dom.
[Graphical view]
PfamiPF01476. LysM. 2 hits.
[Graphical view]
SMARTiSM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYM3_ARATH
AccessioniPrimary (citable) accession number: Q6NPN4
Secondary accession number(s): Q9CAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.