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Protein

LysM domain-containing GPI-anchored protein 3

Gene

LYM3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example).1 Publication

GO - Molecular functioni

  • peptidoglycan binding Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • immune response Source: TAIR

Keywordsi

Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
LysM domain-containing GPI-anchored protein 3
Gene namesi
Name:LYM3
Ordered Locus Names:At1g77630
ORF Names:T5M16.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G77630
TAIRilocus:2204720 AT1G77630

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired sensitivity to peptidoglycans (PGNs) leading to higher susceptibility to infection with virulent Pseudomonas syringae pv. tomato DC3000.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000025212325 – 394LysM domain-containing GPI-anchored protein 3Add BLAST370
PropeptideiPRO_0000252124395 – 423Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 97By similarity
Disulfide bondi37 ↔ 160By similarity
Disulfide bondi95 ↔ 158By similarity
Disulfide bondi97 ↔ 160By similarity
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 253By similarity
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 276By similarity
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi394GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6NPN4

Expressioni

Gene expression databases

ExpressionAtlasiQ6NPN4 differential
GenevisibleiQ6NPN4 AT

Interactioni

Subunit structurei

Interacts with peptidoglycans.1 Publication

Protein-protein interaction databases

STRINGi3702.AT1G77630.1

Structurei

3D structure databases

ProteinModelPortaliQ6NPN4
SMRiQ6NPN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 154LysM 1PROSITE-ProRule annotationAdd BLAST48
Domaini173 – 216LysM 2PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410II8Y Eukaryota
ENOG410YAMN LUCA
HOGENOMiHOG000083326
InParanoidiQ6NPN4
OMAiVPKELMY
OrthoDBiEOG09360D4P
PhylomeDBiQ6NPN4

Family and domain databases

CDDicd00118 LysM, 2 hits
Gene3Di3.10.350.10, 2 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF01476 LysM, 2 hits
SMARTiView protein in SMART
SM00257 LysM, 2 hits
PROSITEiView protein in PROSITE
PS51782 LYSM, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NPN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNPEKPLLL FLILASSLAS MATAKSTIEP CSSKDTCNSL LGYTLYTDLK
60 70 80 90 100
VTEVASLFQV DPVSMLLSNS IDISYPDVEN HVLPAKLFLK IPITCSCVDG
110 120 130 140 150
IRKSLSTHYK TRTSDTLGSI ADSVYGGLVS PEQIQVANSE TDLSVLDVGT
160 170 180 190 200
KLVIPLPCAC FNGTDESLPA LYLSYVVRGI DTMAGIAKRF STSVTDLTNV
210 220 230 240 250
NAMGAPDINP GDILAVPLLA CSSNFPKYAT DYGLIIPNGS YALTAGHCVQ
260 270 280 290 300
CSCVLGSRSM YCEPASISVS CSSMRCRNSN FMLGNITSQQ SSSGCKLTTC
310 320 330 340 350
SYNGFASGTI LTTLSMSLQP RCPGPQQLAP LIAPPDNVPK ELMYLPSPSP
360 370 380 390 400
SPSPEFDDIA GGGSSIAAVP AASPGGATVS SSNSIPGNPA NGPGGSISIA
410 420
SCPLSYYSFI ALLIPIGSCF FVF
Length:423
Mass (Da):44,152
Last modified:July 5, 2004 - v1
Checksum:iB067C6FEBD5ED6D0
GO

Sequence cautioni

The sequence AAG51658 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010704 Genomic DNA Translation: AAG51658.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE36002.1
BT010885 mRNA Translation: AAR24663.1
AK176769 mRNA Translation: BAD44532.1
PIRiH96805
RefSeqiNP_177886.2, NM_106411.4
UniGeneiAt.24354

Genome annotation databases

EnsemblPlantsiAT1G77630.1; AT1G77630.1; AT1G77630
GeneIDi844098
GrameneiAT1G77630.1; AT1G77630.1; AT1G77630
KEGGiath:AT1G77630

Similar proteinsi

Entry informationi

Entry nameiLYM3_ARATH
AccessioniPrimary (citable) accession number: Q6NPN4
Secondary accession number(s): Q9CAP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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