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Q6NMS0 (GSTUC_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase U12

Short name=AtGSTU12
EC=2.5.1.18
Alternative name(s):
GST class-tau member 12
Gene names
Name:GSTU12
Ordered Locus Names:At1g69920
ORF Names:T17F3.5
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Nucleus Ref.6.

Induction

By fungal elicitor. Ref.5

Sequence similarities

Belongs to the GST superfamily. Tau family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence caution

The sequence AAG52553.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Glutathione S-transferase U12
PRO_0000413558

Regions

Domain33 – 11482GST N-terminal
Domain120 – 252133GST C-terminal
Region43 – 442Glutathione binding By similarity
Region71 – 722Glutathione binding By similarity
Region85 – 862Glutathione binding By similarity
Region98 – 992Glutathione binding By similarity
Motif19 – 235Nuclear localization signal Potential

Experimental info

Sequence conflict2441F → S in AAR20744. Ref.3
Sequence conflict2441F → S in AAS46639. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q6NMS0 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 2A152B61669ABA85

FASTA25427,923
        10         20         30         40         50         60 
MLKNKKSDNS LSRDTLQIKK RKKTTMAQNG SNTTVKLIGT WASPFAIRAQ VALHLKSVEH 

        70         80         90        100        110        120 
EYVEETDVLK GKSDLLIKSN PIHKKVPVLI HGDVSICESL NIVQYVDESW PSDLSILPTL 

       130        140        150        160        170        180 
PSERAFARFW AHFVDGKLFE SIDAVAGAKD DAARMTLAGN LMENLAALEE AFQKSSKGGD 

       190        200        210        220        230        240 
FFGGGNIGFV DITVGAIVGP ISVIEAFSGV KFLRPDTTPG LIQWAEKFRA HEAVKPYMPT 

       250 
VAEFIEFAKK KFSV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
Wagner U., Edwards R., Dixon D.P., Mauch F.
Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Necrosis- and ethylene-inducing peptide from Fusarium oxysporum induces a complex cascade of transcripts associated with signal transduction and cell death in Arabidopsis."
Bae H., Kim M.S., Sicher R.C., Bae H.J., Bailey B.A.
Plant Physiol. 141:1056-1067(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[6]"Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010675 Genomic DNA. Translation: AAG52553.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE34998.1.
BT010687 mRNA. Translation: AAR20744.1.
BT011586 mRNA. Translation: AAS46639.1.
PIRF96721.
RefSeqNP_177150.2. NM_105660.5.
UniGeneAt.35363.

3D structure databases

ProteinModelPortalQ6NMS0.
SMRQ6NMS0. Positions 35-251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G69920.1-P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G69920.1; AT1G69920.1; AT1G69920.
GeneID843328.
KEGGath:AT1G69920.

Organism-specific databases

TAIRAT1G69920.

Phylogenomic databases

eggNOGNOG303122.
HOGENOMHOG000125749.
InParanoidQ6NMS0.
KOK00799.
OMAKFRAHEA.

Enzyme and pathway databases

BioCycARA:AT1G69920-MONOMER.

Gene expression databases

GenevestigatorQ6NMS0.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTUC_ARATH
AccessionPrimary (citable) accession number: Q6NMS0
Secondary accession number(s): F4I3V4, Q9CAS5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: February 19, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names