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Q6NMS0

- GSTUC_ARATH

UniProt

Q6NMS0 - GSTUC_ARATH

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Protein

Glutathione S-transferase U12

Gene

GSTU12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: TAIR

GO - Biological processi

  1. glutathione metabolic process Source: TAIR
  2. response to stress Source: UniProtKB-KW
  3. response to toxic substance Source: UniProtKB-KW
  4. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT1G69920-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U12 (EC:2.5.1.18)
Short name:
AtGSTU12
Alternative name(s):
GST class-tau member 12
Gene namesi
Name:GSTU12
Ordered Locus Names:At1g69920
ORF Names:T17F3.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G69920.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Glutathione S-transferase U12PRO_0000413558Add
BLAST

Expressioni

Inductioni

By fungal elicitor.1 Publication

Gene expression databases

GenevestigatoriQ6NMS0.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G69920.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ6NMS0.
SMRiQ6NMS0. Positions 35-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 11482GST N-terminalAdd
BLAST
Domaini120 – 252133GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 442Glutathione bindingBy similarity
Regioni71 – 722Glutathione bindingBy similarity
Regioni85 – 862Glutathione bindingBy similarity
Regioni98 – 992Glutathione bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 235Nuclear localization signalSequence Analysis

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG303122.
HOGENOMiHOG000125749.
InParanoidiQ6NMS0.
KOiK00799.
OMAiKFRAHEA.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NMS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKNKKSDNS LSRDTLQIKK RKKTTMAQNG SNTTVKLIGT WASPFAIRAQ
60 70 80 90 100
VALHLKSVEH EYVEETDVLK GKSDLLIKSN PIHKKVPVLI HGDVSICESL
110 120 130 140 150
NIVQYVDESW PSDLSILPTL PSERAFARFW AHFVDGKLFE SIDAVAGAKD
160 170 180 190 200
DAARMTLAGN LMENLAALEE AFQKSSKGGD FFGGGNIGFV DITVGAIVGP
210 220 230 240 250
ISVIEAFSGV KFLRPDTTPG LIQWAEKFRA HEAVKPYMPT VAEFIEFAKK

KFSV
Length:254
Mass (Da):27,923
Last modified:October 19, 2011 - v2
Checksum:i2A152B61669ABA85
GO

Sequence cautioni

The sequence AAG52553.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441F → S in AAR20744. (PubMed:14593172)Curated
Sequence conflicti244 – 2441F → S in AAS46639. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010675 Genomic DNA. Translation: AAG52553.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE34998.1.
BT010687 mRNA. Translation: AAR20744.1.
BT011586 mRNA. Translation: AAS46639.1.
PIRiF96721.
RefSeqiNP_177150.2. NM_105660.5.
UniGeneiAt.35363.

Genome annotation databases

EnsemblPlantsiAT1G69920.1; AT1G69920.1; AT1G69920.
GeneIDi843328.
KEGGiath:AT1G69920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010675 Genomic DNA. Translation: AAG52553.1 . Different initiation.
CP002684 Genomic DNA. Translation: AEE34998.1 .
BT010687 mRNA. Translation: AAR20744.1 .
BT011586 mRNA. Translation: AAS46639.1 .
PIRi F96721.
RefSeqi NP_177150.2. NM_105660.5.
UniGenei At.35363.

3D structure databases

ProteinModelPortali Q6NMS0.
SMRi Q6NMS0. Positions 35-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G69920.1-P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G69920.1 ; AT1G69920.1 ; AT1G69920 .
GeneIDi 843328.
KEGGi ath:AT1G69920.

Organism-specific databases

TAIRi AT1G69920.

Phylogenomic databases

eggNOGi NOG303122.
HOGENOMi HOG000125749.
InParanoidi Q6NMS0.
KOi K00799.
OMAi KFRAHEA.

Enzyme and pathway databases

BioCyci ARA:AT1G69920-MONOMER.

Gene expression databases

Genevestigatori Q6NMS0.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Necrosis- and ethylene-inducing peptide from Fusarium oxysporum induces a complex cascade of transcripts associated with signal transduction and cell death in Arabidopsis."
    Bae H., Kim M.S., Sicher R.C., Bae H.J., Bailey B.A.
    Plant Physiol. 141:1056-1067(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
    Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
    J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGSTUC_ARATH
AccessioniPrimary (citable) accession number: Q6NMS0
Secondary accession number(s): F4I3V4, Q9CAS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3