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Q6NMA7

- PLCD9_ARATH

UniProt

Q6NMA7 - PLCD9_ARATH

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Protein

Phosphoinositide phospholipase C 9

Gene

PLC9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Calcium.

GO - Molecular functioni

  1. phosphatidylinositol phospholipase C activity Source: TAIR
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium ion homeostasis Source: TAIR
  2. heat acclimation Source: TAIR
  3. intracellular signal transduction Source: InterPro
  4. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT3G47220-MONOMER.
ReactomeiREACT_187614. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 9 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC9
Short name:
AtPLC9
Short name:
PI-PLC9
Gene namesi
Name:PLC9
Ordered Locus Names:At3g47220
ORF Names:F13I12.270
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G47220.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Phosphoinositide phospholipase C 9PRO_0000324134Add
BLAST

Proteomic databases

PaxDbiQ6NMA7.
PRIDEiQ6NMA7.

Expressioni

Tissue specificityi

Expressed in leaves, roots, flowers and siliques.1 Publication

Gene expression databases

GenevestigatoriQ6NMA7.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G47220.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ6NMA7.
SMRiQ6NMA7. Positions 106-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 253147PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini265 – 385121PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini390 – 496107C2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG149692.
HOGENOMiHOG000244119.
InParanoidiQ6NMA7.
PhylomeDBiQ6NMA7.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
InterProiIPR000008. C2_dom.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NMA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNLRKKFEM KQANQPGRVP NYFRNKYHGY DDDMPNLLPT FIKLLDTEKD
60 70 80 90 100
EDGAGLNAAE QIDRELKSRK CDILKFRNLT ILELPHLNEF LFSTELNPPI
110 120 130 140 150
SDQVRHRDMN APLSHYFIHT SLKSYFTGNN VFGRLYSIEP IIDALKQGVR
160 170 180 190 200
VVELDLLPFG KDGICVRPKW NFEKPLELQE CLDAIKQHAF TPTRSYPVII
210 220 230 240 250
TIKDSLKPDL QSKVTQMIDQ TFGDMVYHED PQQSLEEFPS PAELQNKILI
260 270 280 290 300
SRRPPTKLLY AKAVENGVEL EIQEGSTDKN YQSVVGFHAV EPRGMLQKAL
310 320 330 340 350
TDDVQQPGWY ERDVISFTQN KFLRTRPKKR NLLSNPPYKP QRAWMHGAQM
360 370 380 390 400
IALSRQDDKE KLWLMQGMFR ANGGCGYVKK PNFLLNAGSS GVFYPTENPV
410 420 430 440 450
VVKTLKVKIY MGDGWIVDFK KRIGRLSKPD LYVRISIAGV PHDEKIMNTT
460 470 480 490 500
VKNNEWKPTW GEEFTFPLTY PDLALISFEV YDYEVSTPDY FCGQTCLPVS
510 520 530
ELIEGIRAVP LYDERGKACS STMLLTRFKW S
Length:531
Mass (Da):61,165
Last modified:July 5, 2004 - v1
Checksum:i44297407ACADA151
GO

Sequence cautioni

The sequence CAB61968.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133292 Genomic DNA. Translation: CAB61968.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE78257.1.
BT011755 mRNA. Translation: AAS49118.1.
AK226689 mRNA. Translation: BAE98796.1.
PIRiT45658.
RefSeqiNP_190306.2. NM_114589.4.
UniGeneiAt.66519.

Genome annotation databases

EnsemblPlantsiAT3G47220.1; AT3G47220.1; AT3G47220.
GeneIDi823875.
KEGGiath:AT3G47220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133292 Genomic DNA. Translation: CAB61968.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE78257.1 .
BT011755 mRNA. Translation: AAS49118.1 .
AK226689 mRNA. Translation: BAE98796.1 .
PIRi T45658.
RefSeqi NP_190306.2. NM_114589.4.
UniGenei At.66519.

3D structure databases

ProteinModelPortali Q6NMA7.
SMRi Q6NMA7. Positions 106-527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G47220.1-P.

Proteomic databases

PaxDbi Q6NMA7.
PRIDEi Q6NMA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G47220.1 ; AT3G47220.1 ; AT3G47220 .
GeneIDi 823875.
KEGGi ath:AT3G47220.

Organism-specific databases

TAIRi AT3G47220.

Phylogenomic databases

eggNOGi NOG149692.
HOGENOMi HOG000244119.
InParanoidi Q6NMA7.
PhylomeDBi Q6NMA7.

Enzyme and pathway databases

BioCyci ARA:AT3G47220-MONOMER.
Reactomei REACT_187614. Synthesis of IP3 and IP4 in the cytosol.

Gene expression databases

Genevestigatori Q6NMA7.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
InterProi IPR000008. C2_dom.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
Pfami PF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M., Shinozaki K., Ecker J.R.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Gene-specific expression and calcium activation of Arabidopsis thaliana phospholipase C isoforms."
    Hunt L., Otterhag L., Lee J.C., Lasheen T., Hunt J., Seki M., Shinozaki K., Sommarin M., Gilmour D.J., Pical C., Gray J.E.
    New Phytol. 162:643-654(2004)
    [AGRICOLA] [Europe PMC]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLCD9_ARATH
AccessioniPrimary (citable) accession number: Q6NMA7
Secondary accession number(s): Q9SD51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Contains substitutions of several amino acids thought to be essential for catalytic activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3