ID   XRI1_ARATH              Reviewed;         300 AA.
AC   Q6NLW5; Q9FKC4;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   24-JAN-2024, entry version 95.
DE   RecName: Full=Protein XRI1;
DE   AltName: Full=Protein X-RAY INDUCED 1;
GN   Name=XRI1; OrderedLocusNames=At5g48720; ORFNames=K24G6.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INDUCTION BY X-RAYS,
RP   SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND INTERACTION WITH MIP1.
RX   PubMed=19187040; DOI=10.1111/j.1365-313x.2009.03814.x;
RA   Dean P.J., Siwiec T., Waterworth W.M., Schloegelhofer P., Armstrong S.J.,
RA   West C.E.;
RT   "A novel ATM dependant X-ray inducible gene is essential for both plant
RT   meiosis and gametogenesis.";
RL   Plant J. 58:791-802(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA   Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT   features of the regions of 1,367,185 bp covered by 19 physically assigned
RT   P1 and TAC clones.";
RL   DNA Res. 5:203-216(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INDUCTION BY BLEOMYCIN.
RX   PubMed=15506937; DOI=10.1042/bst0320964;
RA   West C.E., Waterworth W.M., Sunderland P.A., Bray C.M.;
RT   "Arabidopsis DNA double-strand break repair pathways.";
RL   Biochem. Soc. Trans. 32:964-966(2004).
CC   -!- FUNCTION: Required for mitotic division of the generative cell nucleus
CC       and the development of mature tricellular pollen grains, and for male
CC       and female meiosis. {ECO:0000269|PubMed:19187040}.
CC   -!- SUBUNIT: Interacts (via C-terminal domain) with MIP1.
CC       {ECO:0000269|PubMed:19187040}.
CC   -!- INTERACTION:
CC       Q6NLW5; Q8RX22: MIP1; NbExp=2; IntAct=EBI-2270660, EBI-2270543;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19187040}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6NLW5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6NLW5-2; Sequence=VSP_037542;
CC   -!- INDUCTION: By X-rays and bleomycin treatment.
CC       {ECO:0000269|PubMed:15506937, ECO:0000269|PubMed:19187040}.
CC   -!- DISRUPTION PHENOTYPE: Complete sterility.
CC       {ECO:0000269|PubMed:19187040}.
CC   -!- MISCELLANEOUS: The induction by X-rays is dependent on DNA damage
CC       signaling by ATM.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB09425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB012242; BAB09425.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED95715.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95716.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM68399.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM68400.1; -; Genomic_DNA.
DR   EMBL; BT012214; AAS76701.1; -; mRNA.
DR   EMBL; BT020567; AAW78586.1; -; mRNA.
DR   RefSeq; NP_001154770.1; NM_001161298.2. [Q6NLW5-1]
DR   RefSeq; NP_001330159.1; NM_001344803.1. [Q6NLW5-2]
DR   RefSeq; NP_001330160.1; NM_001344804.1. [Q6NLW5-1]
DR   RefSeq; NP_199683.2; NM_124249.3. [Q6NLW5-2]
DR   AlphaFoldDB; Q6NLW5; -.
DR   BioGRID; 20176; 1.
DR   IntAct; Q6NLW5; 1.
DR   STRING; 3702.Q6NLW5; -.
DR   PaxDb; 3702-AT5G48720-2; -.
DR   ProteomicsDB; 242797; -. [Q6NLW5-1]
DR   EnsemblPlants; AT5G48720.1; AT5G48720.1; AT5G48720. [Q6NLW5-2]
DR   EnsemblPlants; AT5G48720.2; AT5G48720.2; AT5G48720. [Q6NLW5-1]
DR   EnsemblPlants; AT5G48720.3; AT5G48720.3; AT5G48720. [Q6NLW5-2]
DR   EnsemblPlants; AT5G48720.4; AT5G48720.4; AT5G48720. [Q6NLW5-1]
DR   GeneID; 834930; -.
DR   Gramene; AT5G48720.1; AT5G48720.1; AT5G48720. [Q6NLW5-2]
DR   Gramene; AT5G48720.2; AT5G48720.2; AT5G48720. [Q6NLW5-1]
DR   Gramene; AT5G48720.3; AT5G48720.3; AT5G48720. [Q6NLW5-2]
DR   Gramene; AT5G48720.4; AT5G48720.4; AT5G48720. [Q6NLW5-1]
DR   KEGG; ath:AT5G48720; -.
DR   Araport; AT5G48720; -.
DR   TAIR; AT5G48720; XRI1.
DR   eggNOG; ENOG502QTT2; Eukaryota.
DR   InParanoid; Q6NLW5; -.
DR   OMA; QSQEYDL; -.
DR   OrthoDB; 374721at2759; -.
DR   PhylomeDB; Q6NLW5; -.
DR   PRO; PR:Q6NLW5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q6NLW5; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0006281; P:DNA repair; IMP:TAIR.
DR   GO; GO:0007143; P:female meiotic nuclear division; IMP:TAIR.
DR   GO; GO:0007140; P:male meiotic nuclear division; IMP:TAIR.
DR   GO; GO:0009555; P:pollen development; IMP:TAIR.
DR   GO; GO:0010165; P:response to X-ray; IEP:TAIR.
DR   InterPro; IPR039933; XRI1.
DR   PANTHER; PTHR33385; PROTEIN XRI1; 1.
DR   PANTHER; PTHR33385:SF4; PROTEIN XRI1; 1.
DR   Genevisible; Q6NLW5; AT.
PE   1: Evidence at protein level;
KW   Alternative splicing; Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..300
FT                   /note="Protein XRI1"
FT                   /id="PRO_0000378327"
FT   VAR_SEQ         1..34
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.4"
FT                   /id="VSP_037542"
SQ   SEQUENCE   300 AA;  33719 MW;  23B32F668BDB6FEA CRC64;
     MDYGDDDRSS SWNWQVDNYN HQPQSHFSDV PDCTMTEVTL NQEDHSYMFD DENTPVKACS
     ELGYHVTTED TNRKMEVHSE TRSALKRRRM LQFEDQPETS LFSSESFSAI LKSSARDDTF
     DELLPEGSQL IEGFSEDASA SSFEGLDLYA EEWYADCLND AETPMLPDDL NFGSPDVQVD
     ISEYLNVPPE TETREVQRPV TRSSPNVIFK GRKSFSRPVS KLPSSIIYPF AFIKPCGVHG
     GMTLKDINQK IRNPPAKPKA HIEEPAVIQT SAFSGKPVVG KTKIRTEGGK GSITIMRTRG
//