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Q6NLB0

- GSTL1_ARATH

UniProt

Q6NLB0 - GSTL1_ARATH

Protein

Glutathione S-transferase L1

Gene

GSTL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin. In vitro, possesses glutathione-dependent thiol transferase activity toward 2-hydroxyethyl disulfide (HED).2 Publications

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glutathionylation Source: TAIR
    2. response to stress Source: UniProtKB-KW
    3. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification, Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase L1 (EC:2.5.1.18)
    Short name:
    AtGSTL1
    Alternative name(s):
    GST class-lambda member 1
    Gene namesi
    Name:GSTL1
    Ordered Locus Names:At5g02780
    ORF Names:F9G14.90
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G02780.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Glutathione S-transferase L1PRO_0000413577Add
    BLAST

    Proteomic databases

    PRIDEiQ6NLB0.

    Expressioni

    Inductioni

    By glutathione, ascorbate and auxin.1 Publication

    Gene expression databases

    GenevestigatoriQ6NLB0.

    Interactioni

    Protein-protein interaction databases

    BioGridi17076. 1 interaction.
    IntActiQ6NLB0. 1 interaction.
    STRINGi3702.AT5G02780.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NLB0.
    SMRiQ6NLB0. Positions 21-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 11082GST N-terminalAdd
    BLAST
    Domaini112 – 232121GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni39 – 402Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity
    Regioni81 – 822Glutathione bindingBy similarity
    Regioni94 – 952Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Lambda family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000239968.
    InParanoidiQ9LZ07.
    KOiK00799.
    OMAiIFLSEVF.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13409. GST_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NLB0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALSPPKIFV EDRQVPLDAT SDPPALFDGT TRLYISYTCP FAQRVWITRN    50
    LKGLQDEIKL VPIDLPNRPA WLKEKVNPAN KVPALEHNGK ITGESLDLIK 100
    YVDSNFDGPS LYPEDSAKRE FGEELLKYVD ETFVKTVFGS FKGDPVKETA 150
    SAFDHVENAL KKFDDGPFFL GELSLVDIAY IPFIERFQVF LDEVFKYEII 200
    IGRPNLAAWI EQMNKMVAYT QTKTDSEYVV NYFKRFM 237
    Length:237
    Mass (Da):27,167
    Last modified:July 5, 2004 - v1
    Checksum:iECF926492EB1F30A
    GO
    Isoform 2 (identifier: Q6NLB0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-151: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:235
    Mass (Da):27,009
    Checksum:i4D9E4B7F9BCA745E
    GO

    Sequence cautioni

    The sequence CAB86032.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei150 – 1512Missing in isoform 2. CuratedVSP_041941

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL162973 Genomic DNA. Translation: CAB86032.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED90516.1.
    CP002688 Genomic DNA. Translation: AED90517.1.
    BT010718 mRNA. Translation: AAR20775.1.
    BT012424 mRNA. Translation: AAS92340.1.
    PIRiT48299.
    RefSeqiNP_001119157.1. NM_001125685.1. [Q6NLB0-2]
    NP_195898.2. NM_120356.3. [Q6NLB0-1]
    UniGeneiAt.33366.

    Genome annotation databases

    EnsemblPlantsiAT5G02780.1; AT5G02780.1; AT5G02780. [Q6NLB0-1]
    GeneIDi831800.
    KEGGiath:AT5G02780.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL162973 Genomic DNA. Translation: CAB86032.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED90516.1 .
    CP002688 Genomic DNA. Translation: AED90517.1 .
    BT010718 mRNA. Translation: AAR20775.1 .
    BT012424 mRNA. Translation: AAS92340.1 .
    PIRi T48299.
    RefSeqi NP_001119157.1. NM_001125685.1. [Q6NLB0-2 ]
    NP_195898.2. NM_120356.3. [Q6NLB0-1 ]
    UniGenei At.33366.

    3D structure databases

    ProteinModelPortali Q6NLB0.
    SMRi Q6NLB0. Positions 21-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 17076. 1 interaction.
    IntActi Q6NLB0. 1 interaction.
    STRINGi 3702.AT5G02780.1-P.

    Proteomic databases

    PRIDEi Q6NLB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G02780.1 ; AT5G02780.1 ; AT5G02780 . [Q6NLB0-1 ]
    GeneIDi 831800.
    KEGGi ath:AT5G02780.

    Organism-specific databases

    TAIRi AT5G02780.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000239968.
    InParanoidi Q9LZ07.
    KOi K00799.
    OMAi IFLSEVF.

    Gene expression databases

    Genevestigatori Q6NLB0.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13409. GST_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis cDNA clones."
      Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana."
      Dixon D.P., Davis B.G., Edwards R.
      J. Biol. Chem. 277:30859-30869(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    6. "Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing."
      Dixon D.P., Edwards R.
      J. Biol. Chem. 285:36322-36329(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGSTL1_ARATH
    AccessioniPrimary (citable) accession number: Q6NLB0
    Secondary accession number(s): B3H6S5, Q9LZ07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3