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Q6NLB0

- GSTL1_ARATH

UniProt

Q6NLB0 - GSTL1_ARATH

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Protein

Glutathione S-transferase L1

Gene

GSTL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin. In vitro, possesses glutathione-dependent thiol transferase activity toward 2-hydroxyethyl disulfide (HED).2 Publications

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glutathionylation Source: TAIR
  2. response to stress Source: UniProtKB-KW
  3. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification, Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase L1 (EC:2.5.1.18)
Short name:
AtGSTL1
Alternative name(s):
GST class-lambda member 1
Gene namesi
Name:GSTL1
Ordered Locus Names:At5g02780
ORF Names:F9G14.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G02780.

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Glutathione S-transferase L1PRO_0000413577Add
BLAST

Proteomic databases

PRIDEiQ6NLB0.

Expressioni

Inductioni

By glutathione, ascorbate and auxin.1 Publication

Gene expression databases

GenevestigatoriQ6NLB0.

Interactioni

Protein-protein interaction databases

BioGridi17076. 1 interaction.
IntActiQ6NLB0. 1 interaction.
STRINGi3702.AT5G02780.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ6NLB0.
SMRiQ6NLB0. Positions 16-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11082GST N-terminalAdd
BLAST
Domaini112 – 232121GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 402Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity
Regioni81 – 822Glutathione bindingBy similarity
Regioni94 – 952Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Lambda family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000239968.
InParanoidiQ6NLB0.
KOiK00799.
OMAiIFLSEVF.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NLB0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSPPKIFV EDRQVPLDAT SDPPALFDGT TRLYISYTCP FAQRVWITRN
60 70 80 90 100
LKGLQDEIKL VPIDLPNRPA WLKEKVNPAN KVPALEHNGK ITGESLDLIK
110 120 130 140 150
YVDSNFDGPS LYPEDSAKRE FGEELLKYVD ETFVKTVFGS FKGDPVKETA
160 170 180 190 200
SAFDHVENAL KKFDDGPFFL GELSLVDIAY IPFIERFQVF LDEVFKYEII
210 220 230
IGRPNLAAWI EQMNKMVAYT QTKTDSEYVV NYFKRFM
Length:237
Mass (Da):27,167
Last modified:July 5, 2004 - v1
Checksum:iECF926492EB1F30A
GO
Isoform 2 (identifier: Q6NLB0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-151: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:235
Mass (Da):27,009
Checksum:i4D9E4B7F9BCA745E
GO

Sequence cautioni

The sequence CAB86032.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei150 – 1512Missing in isoform 2. CuratedVSP_041941

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL162973 Genomic DNA. Translation: CAB86032.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90516.1.
CP002688 Genomic DNA. Translation: AED90517.1.
BT010718 mRNA. Translation: AAR20775.1.
BT012424 mRNA. Translation: AAS92340.1.
PIRiT48299.
RefSeqiNP_001119157.1. NM_001125685.1. [Q6NLB0-2]
NP_195898.2. NM_120356.3. [Q6NLB0-1]
UniGeneiAt.33366.

Genome annotation databases

EnsemblPlantsiAT5G02780.1; AT5G02780.1; AT5G02780. [Q6NLB0-1]
GeneIDi831800.
KEGGiath:AT5G02780.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL162973 Genomic DNA. Translation: CAB86032.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED90516.1 .
CP002688 Genomic DNA. Translation: AED90517.1 .
BT010718 mRNA. Translation: AAR20775.1 .
BT012424 mRNA. Translation: AAS92340.1 .
PIRi T48299.
RefSeqi NP_001119157.1. NM_001125685.1. [Q6NLB0-2 ]
NP_195898.2. NM_120356.3. [Q6NLB0-1 ]
UniGenei At.33366.

3D structure databases

ProteinModelPortali Q6NLB0.
SMRi Q6NLB0. Positions 16-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 17076. 1 interaction.
IntActi Q6NLB0. 1 interaction.
STRINGi 3702.AT5G02780.1-P.

Proteomic databases

PRIDEi Q6NLB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G02780.1 ; AT5G02780.1 ; AT5G02780 . [Q6NLB0-1 ]
GeneIDi 831800.
KEGGi ath:AT5G02780.

Organism-specific databases

TAIRi AT5G02780.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000239968.
InParanoidi Q6NLB0.
KOi K00799.
OMAi IFLSEVF.

Gene expression databases

Genevestigatori Q6NLB0.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13409. GST_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis cDNA clones."
    Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana."
    Dixon D.P., Davis B.G., Edwards R.
    J. Biol. Chem. 277:30859-30869(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  6. "Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing."
    Dixon D.P., Edwards R.
    J. Biol. Chem. 285:36322-36329(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGSTL1_ARATH
AccessioniPrimary (citable) accession number: Q6NLB0
Secondary accession number(s): B3H6S5, Q9LZ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3