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Q6NLB0 (GSTL1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase L1

Short name=AtGSTL1
EC=2.5.1.18
Alternative name(s):
GST class-lambda member 1
Gene names
Name:GSTL1
Ordered Locus Names:At5g02780
ORF Names:F9G14.90
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin. In vitro, possesses glutathione-dependent thiol transferase activity toward 2-hydroxyethyl disulfide (HED). Ref.5 Ref.6

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Cytoplasmcytosol Probable.

Induction

By glutathione, ascorbate and auxin. Ref.5

Sequence similarities

Belongs to the GST superfamily. Lambda family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence caution

The sequence CAB86032.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processDetoxification
Stress response
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein glutathionylation

Inferred from direct assay Ref.5. Source: TAIR

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

response to toxic substance

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6NLB0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6NLB0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     150-151: Missing.
Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Glutathione S-transferase L1
PRO_0000413577

Regions

Domain29 – 11082GST N-terminal
Domain112 – 232121GST C-terminal
Region39 – 402Glutathione binding By similarity
Region67 – 682Glutathione binding By similarity
Region81 – 822Glutathione binding By similarity
Region94 – 952Glutathione binding By similarity

Natural variations

Alternative sequence150 – 1512Missing in isoform 2.
VSP_041941

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: ECF926492EB1F30A

FASTA23727,167
        10         20         30         40         50         60 
MALSPPKIFV EDRQVPLDAT SDPPALFDGT TRLYISYTCP FAQRVWITRN LKGLQDEIKL 

        70         80         90        100        110        120 
VPIDLPNRPA WLKEKVNPAN KVPALEHNGK ITGESLDLIK YVDSNFDGPS LYPEDSAKRE 

       130        140        150        160        170        180 
FGEELLKYVD ETFVKTVFGS FKGDPVKETA SAFDHVENAL KKFDDGPFFL GELSLVDIAY 

       190        200        210        220        230 
IPFIERFQVF LDEVFKYEII IGRPNLAAWI EQMNKMVAYT QTKTDSEYVV NYFKRFM 

« Hide

Isoform 2 [UniParc].

Checksum: 4D9E4B7F9BCA745E
Show »

FASTA23527,009

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. expand/collapse author list , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis cDNA clones."
Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[4]"Arabidopsis ORF clones."
Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[5]"Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana."
Dixon D.P., Davis B.G., Edwards R.
J. Biol. Chem. 277:30859-30869(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[6]"Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing."
Dixon D.P., Edwards R.
J. Biol. Chem. 285:36322-36329(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL162973 Genomic DNA. Translation: CAB86032.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90516.1.
CP002688 Genomic DNA. Translation: AED90517.1.
BT010718 mRNA. Translation: AAR20775.1.
BT012424 mRNA. Translation: AAS92340.1.
PIRT48299.
RefSeqNP_001119157.1. NM_001125685.1. [Q6NLB0-2]
NP_195898.2. NM_120356.3. [Q6NLB0-1]
UniGeneAt.33366.

3D structure databases

ProteinModelPortalQ6NLB0.
SMRQ6NLB0. Positions 21-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid17076. 1 interaction.
IntActQ6NLB0. 1 interaction.
STRING3702.AT5G02780.1-P.

Proteomic databases

PRIDEQ6NLB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G02780.1; AT5G02780.1; AT5G02780. [Q6NLB0-1]
GeneID831800.
KEGGath:AT5G02780.

Organism-specific databases

TAIRAT5G02780.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000239968.
InParanoidQ9LZ07.
KOK00799.
OMAIFLSEVF.

Gene expression databases

GenevestigatorQ6NLB0.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTL1_ARATH
AccessionPrimary (citable) accession number: Q6NLB0
Secondary accession number(s): B3H6S5, Q9LZ07
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names