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Q6NKX1 (PROD2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline dehydrogenase 2, mitochondrial

EC=1.5.5.2
Alternative name(s):
Osmotic stress-induced proline dehydrogenase
Proline oxidase
Gene names
Name:POX2
Synonyms:PRODH2
Ordered Locus Names:At5g38710
ORF Names:MKD10.10
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts proline to delta-1-pyrroline-5-carboxylate. Ref.7

Catalytic activity

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.

Cofactor

FAD.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.

Subcellular location

Mitochondrion Ref.7.

Tissue specificity

Expressed in the vascular tissue and in the abscission zone of petals, sepals, stamina, pistils and siliques. Not detected in petioles. Ref.7

Developmental stage

Strongly expressed in senescent leaves. Ref.7

Induction

Down-regulated by high succrose; via the repression of bZIP11. Up-regulated by proline and salt or drought stress. Ref.5 Ref.6 Ref.7

Disruption phenotype

No visible phenotype when grown under normal conditions. No proline hypersensitivity. Ref.7

Sequence similarities

Belongs to the proline oxidase family.

Sequence caution

The sequence BAB10129.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion Potential
Chain30 – 476447Proline dehydrogenase 2, mitochondrial
PRO_0000394797

Regions

Compositional bias114 – 1185Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q6NKX1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F15FBDF8E06A13F3

FASTA47653,074
        10         20         30         40         50         60 
MANRFLRPNL IHRFSTVSPV GPPTTIIPEI LSFDQPKPEV DLDLSDQARL FASVPISTLL 

        70         80         90        100        110        120 
RSTAILHATS IGPMVDLGSW LMSSKLMDTT VTRDLVLRIV KGTFYDHFCA GEDAAAAARR 

       130        140        150        160        170        180 
VSSVYESTGL KGMLVYGVEH AEDGGACDEN IQKFIETVEA AKTLPSSHLS SVVVKITAIC 

       190        200        210        220        230        240 
PMNVLKRVSD LLRWQYKNPN FKLPWKLNSF PVFSGLSPLY HTTSEPEPLT VEEERELEKA 

       250        260        270        280        290        300 
HERLKSVCLR CQESNVPLLI DAEDTILQPA IDYMAYWSAI MFNSDKDRPI VYNTIQAYLK 

       310        320        330        340        350        360 
DAGERLHLAL RESEKMNVPI GFKLVRGAYM SSEAKLADSL GYKSPVHDTI QNTHDCYNDC 

       370        380        390        400        410        420 
MSFLMEKASN GSGIAVILAT HNTDSGKLGA RKASELGINK ENGKIEFAQL YGMSDALSFG 

       430        440        450        460        470 
LKRAGFNVSK YMPYGPVDTA IPYLIRRAYE NRGMMSTGAL DRQLMRKELK RRVMAW 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Shinn P., Chen H., Cheuk R., Kim C.J., Carninci P., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M., Shinozaki K., Ecker J.R.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Two tobacco proline dehydrogenases are differentially regulated and play a role in early plant development."
Ribarits A., Abdullaev A., Tashpulatov A., Richter A., Heberle-Bors E., Touraev A.
Planta 225:1313-1324(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[6]"The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2."
Hanson J., Hanssen M., Wiese A., Hendriks M.M., Smeekens S.
Plant J. 53:935-949(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis."
Funck D., Eckard S., Mueller G.
BMC Plant Biol. 10:70-70(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011478 Genomic DNA. Translation: BAB10129.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED94352.1.
BT012572 mRNA. Translation: AAS99716.1.
AK221601 mRNA. Translation: BAD95150.1.
RefSeqNP_198687.1. NM_123232.2.
UniGeneAt.50494.

3D structure databases

ProteinModelPortalQ6NKX1.
SMRQ6NKX1. Positions 211-451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT5G38710.1-P.

Proteomic databases

PRIDEQ6NKX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G38710.1; AT5G38710.1; AT5G38710.
GeneID833862.
KEGGath:AT5G38710.

Organism-specific databases

TAIRAT5G38710.

Phylogenomic databases

eggNOGCOG0506.
HOGENOMHOG000243575.
InParanoidQ6NKX1.
KOK00318.
OMASKYMPYG.
PhylomeDBQ6NKX1.

Enzyme and pathway databases

BioCycARA:AT5G38710-MONOMER.
MetaCyc:AT5G38710-MONOMER.
UniPathwayUPA00261; UER00373.

Gene expression databases

GenevestigatorQ6NKX1.

Family and domain databases

Gene3D3.20.20.220. 2 hits.
InterProIPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERPTHR13914. PTHR13914. 1 hit.
PfamPF01619. Pro_dh. 1 hit.
[Graphical view]
SUPFAMSSF51730. SSF51730. 2 hits.
ProtoNetSearch...

Other

PROQ6NKX1.

Entry information

Entry namePROD2_ARATH
AccessionPrimary (citable) accession number: Q6NKX1
Secondary accession number(s): Q9FKR5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names