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Q6NKX1

- PROD2_ARATH

UniProt

Q6NKX1 - PROD2_ARATH

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Protein

Proline dehydrogenase 2, mitochondrial

Gene
POX2, PRODH2, At5g38710, MKD10.10
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts proline to delta-1-pyrroline-5-carboxylate.1 Publication

Catalytic activityi

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.

Cofactori

FAD.

Pathwayi

GO - Molecular functioni

  1. proline dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: InterPro
  2. proline catabolic process Source: UniProtKB
  3. proline catabolic process to glutamate Source: UniProtKB-UniPathway
  4. response to osmotic stress Source: UniProtKB
  5. response to water deprivation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Proline metabolism, Stress response

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT5G38710-MONOMER.
MetaCyc:AT5G38710-MONOMER.
UniPathwayiUPA00261; UER00373.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline dehydrogenase 2, mitochondrial (EC:1.5.5.2)
Alternative name(s):
Osmotic stress-induced proline dehydrogenase
Proline oxidase
Gene namesi
Name:POX2
Synonyms:PRODH2
Ordered Locus Names:At5g38710
ORF Names:MKD10.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G38710.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No visible phenotype when grown under normal conditions. No proline hypersensitivity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion Reviewed predictionAdd
BLAST
Chaini30 – 476447Proline dehydrogenase 2, mitochondrialPRO_0000394797Add
BLAST

Proteomic databases

PRIDEiQ6NKX1.

Expressioni

Tissue specificityi

Expressed in the vascular tissue and in the abscission zone of petals, sepals, stamina, pistils and siliques. Not detected in petioles.1 Publication

Developmental stagei

Strongly expressed in senescent leaves.1 Publication

Inductioni

Down-regulated by high succrose; via the repression of bZIP11. Up-regulated by proline and salt or drought stress.3 Publications

Gene expression databases

GenevestigatoriQ6NKX1.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G38710.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ6NKX1.
SMRiQ6NKX1. Positions 211-451.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi114 – 1185Poly-Ala

Sequence similaritiesi

Belongs to the proline oxidase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0506.
HOGENOMiHOG000243575.
InParanoidiQ6NKX1.
KOiK00318.
OMAiSKYMPYG.
PhylomeDBiQ6NKX1.

Family and domain databases

Gene3Di3.20.20.220. 2 hits.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiPF01619. Pro_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NKX1-1 [UniParc]FASTAAdd to Basket

« Hide

MANRFLRPNL IHRFSTVSPV GPPTTIIPEI LSFDQPKPEV DLDLSDQARL    50
FASVPISTLL RSTAILHATS IGPMVDLGSW LMSSKLMDTT VTRDLVLRIV 100
KGTFYDHFCA GEDAAAAARR VSSVYESTGL KGMLVYGVEH AEDGGACDEN 150
IQKFIETVEA AKTLPSSHLS SVVVKITAIC PMNVLKRVSD LLRWQYKNPN 200
FKLPWKLNSF PVFSGLSPLY HTTSEPEPLT VEEERELEKA HERLKSVCLR 250
CQESNVPLLI DAEDTILQPA IDYMAYWSAI MFNSDKDRPI VYNTIQAYLK 300
DAGERLHLAL RESEKMNVPI GFKLVRGAYM SSEAKLADSL GYKSPVHDTI 350
QNTHDCYNDC MSFLMEKASN GSGIAVILAT HNTDSGKLGA RKASELGINK 400
ENGKIEFAQL YGMSDALSFG LKRAGFNVSK YMPYGPVDTA IPYLIRRAYE 450
NRGMMSTGAL DRQLMRKELK RRVMAW 476
Length:476
Mass (Da):53,074
Last modified:July 5, 2004 - v1
Checksum:iF15FBDF8E06A13F3
GO

Sequence cautioni

The sequence BAB10129.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011478 Genomic DNA. Translation: BAB10129.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED94352.1.
BT012572 mRNA. Translation: AAS99716.1.
AK221601 mRNA. Translation: BAD95150.1.
RefSeqiNP_198687.1. NM_123232.2.
UniGeneiAt.50494.

Genome annotation databases

EnsemblPlantsiAT5G38710.1; AT5G38710.1; AT5G38710.
GeneIDi833862.
KEGGiath:AT5G38710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011478 Genomic DNA. Translation: BAB10129.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED94352.1 .
BT012572 mRNA. Translation: AAS99716.1 .
AK221601 mRNA. Translation: BAD95150.1 .
RefSeqi NP_198687.1. NM_123232.2.
UniGenei At.50494.

3D structure databases

ProteinModelPortali Q6NKX1.
SMRi Q6NKX1. Positions 211-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G38710.1-P.

Proteomic databases

PRIDEi Q6NKX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G38710.1 ; AT5G38710.1 ; AT5G38710 .
GeneIDi 833862.
KEGGi ath:AT5G38710.

Organism-specific databases

TAIRi AT5G38710.

Phylogenomic databases

eggNOGi COG0506.
HOGENOMi HOG000243575.
InParanoidi Q6NKX1.
KOi K00318.
OMAi SKYMPYG.
PhylomeDBi Q6NKX1.

Enzyme and pathway databases

UniPathwayi UPA00261 ; UER00373 .
BioCyci ARA:AT5G38710-MONOMER.
MetaCyc:AT5G38710-MONOMER.

Miscellaneous databases

PROi Q6NKX1.

Gene expression databases

Genevestigatori Q6NKX1.

Family and domain databases

Gene3Di 3.20.20.220. 2 hits.
InterProi IPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
[Graphical view ]
PANTHERi PTHR13914. PTHR13914. 1 hit.
Pfami PF01619. Pro_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF51730. SSF51730. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Cheuk R., Kim C.J., Carninci P., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M., Shinozaki K., Ecker J.R.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Two tobacco proline dehydrogenases are differentially regulated and play a role in early plant development."
    Ribarits A., Abdullaev A., Tashpulatov A., Richter A., Heberle-Bors E., Touraev A.
    Planta 225:1313-1324(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2."
    Hanson J., Hanssen M., Wiese A., Hendriks M.M., Smeekens S.
    Plant J. 53:935-949(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis."
    Funck D., Eckard S., Mueller G.
    BMC Plant Biol. 10:70-70(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPROD2_ARATH
AccessioniPrimary (citable) accession number: Q6NKX1
Secondary accession number(s): Q9FKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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