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Q6NKX1

- PROD2_ARATH

UniProt

Q6NKX1 - PROD2_ARATH

Protein

Proline dehydrogenase 2, mitochondrial

Gene

POX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Converts proline to delta-1-pyrroline-5-carboxylate.1 Publication

    Catalytic activityi

    L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    GO - Molecular functioni

    1. proline dehydrogenase activity Source: UniProtKB

    GO - Biological processi

    1. glutamate biosynthetic process Source: InterPro
    2. proline catabolic process Source: UniProtKB
    3. proline catabolic process to glutamate Source: UniProtKB-UniPathway
    4. response to osmotic stress Source: UniProtKB
    5. response to water deprivation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Proline metabolism, Stress response

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciARA:AT5G38710-MONOMER.
    MetaCyc:AT5G38710-MONOMER.
    UniPathwayiUPA00261; UER00373.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline dehydrogenase 2, mitochondrial (EC:1.5.5.2)
    Alternative name(s):
    Osmotic stress-induced proline dehydrogenase
    Proline oxidase
    Gene namesi
    Name:POX2
    Synonyms:PRODH2
    Ordered Locus Names:At5g38710
    ORF Names:MKD10.10
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G38710.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype when grown under normal conditions. No proline hypersensitivity.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 476447Proline dehydrogenase 2, mitochondrialPRO_0000394797Add
    BLAST

    Proteomic databases

    PRIDEiQ6NKX1.

    Expressioni

    Tissue specificityi

    Expressed in the vascular tissue and in the abscission zone of petals, sepals, stamina, pistils and siliques. Not detected in petioles.1 Publication

    Developmental stagei

    Strongly expressed in senescent leaves.1 Publication

    Inductioni

    Down-regulated by high succrose; via the repression of bZIP11. Up-regulated by proline and salt or drought stress.3 Publications

    Gene expression databases

    GenevestigatoriQ6NKX1.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G38710.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NKX1.
    SMRiQ6NKX1. Positions 211-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi114 – 1185Poly-Ala

    Sequence similaritiesi

    Belongs to the proline oxidase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0506.
    HOGENOMiHOG000243575.
    InParanoidiQ6NKX1.
    KOiK00318.
    OMAiSKYMPYG.
    PhylomeDBiQ6NKX1.

    Family and domain databases

    Gene3Di3.20.20.220. 2 hits.
    InterProiIPR029041. FAD-linked_oxidoreductase-like.
    IPR002872. Proline_DH_dom.
    IPR015659. Proline_oxidase.
    [Graphical view]
    PANTHERiPTHR13914. PTHR13914. 1 hit.
    PfamiPF01619. Pro_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF51730. SSF51730. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6NKX1-1 [UniParc]FASTAAdd to Basket

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    MANRFLRPNL IHRFSTVSPV GPPTTIIPEI LSFDQPKPEV DLDLSDQARL    50
    FASVPISTLL RSTAILHATS IGPMVDLGSW LMSSKLMDTT VTRDLVLRIV 100
    KGTFYDHFCA GEDAAAAARR VSSVYESTGL KGMLVYGVEH AEDGGACDEN 150
    IQKFIETVEA AKTLPSSHLS SVVVKITAIC PMNVLKRVSD LLRWQYKNPN 200
    FKLPWKLNSF PVFSGLSPLY HTTSEPEPLT VEEERELEKA HERLKSVCLR 250
    CQESNVPLLI DAEDTILQPA IDYMAYWSAI MFNSDKDRPI VYNTIQAYLK 300
    DAGERLHLAL RESEKMNVPI GFKLVRGAYM SSEAKLADSL GYKSPVHDTI 350
    QNTHDCYNDC MSFLMEKASN GSGIAVILAT HNTDSGKLGA RKASELGINK 400
    ENGKIEFAQL YGMSDALSFG LKRAGFNVSK YMPYGPVDTA IPYLIRRAYE 450
    NRGMMSTGAL DRQLMRKELK RRVMAW 476
    Length:476
    Mass (Da):53,074
    Last modified:July 5, 2004 - v1
    Checksum:iF15FBDF8E06A13F3
    GO

    Sequence cautioni

    The sequence BAB10129.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011478 Genomic DNA. Translation: BAB10129.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED94352.1.
    BT012572 mRNA. Translation: AAS99716.1.
    AK221601 mRNA. Translation: BAD95150.1.
    RefSeqiNP_198687.1. NM_123232.2.
    UniGeneiAt.50494.

    Genome annotation databases

    EnsemblPlantsiAT5G38710.1; AT5G38710.1; AT5G38710.
    GeneIDi833862.
    KEGGiath:AT5G38710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011478 Genomic DNA. Translation: BAB10129.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED94352.1 .
    BT012572 mRNA. Translation: AAS99716.1 .
    AK221601 mRNA. Translation: BAD95150.1 .
    RefSeqi NP_198687.1. NM_123232.2.
    UniGenei At.50494.

    3D structure databases

    ProteinModelPortali Q6NKX1.
    SMRi Q6NKX1. Positions 211-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G38710.1-P.

    Proteomic databases

    PRIDEi Q6NKX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G38710.1 ; AT5G38710.1 ; AT5G38710 .
    GeneIDi 833862.
    KEGGi ath:AT5G38710.

    Organism-specific databases

    TAIRi AT5G38710.

    Phylogenomic databases

    eggNOGi COG0506.
    HOGENOMi HOG000243575.
    InParanoidi Q6NKX1.
    KOi K00318.
    OMAi SKYMPYG.
    PhylomeDBi Q6NKX1.

    Enzyme and pathway databases

    UniPathwayi UPA00261 ; UER00373 .
    BioCyci ARA:AT5G38710-MONOMER.
    MetaCyc:AT5G38710-MONOMER.

    Miscellaneous databases

    PROi Q6NKX1.

    Gene expression databases

    Genevestigatori Q6NKX1.

    Family and domain databases

    Gene3Di 3.20.20.220. 2 hits.
    InterProi IPR029041. FAD-linked_oxidoreductase-like.
    IPR002872. Proline_DH_dom.
    IPR015659. Proline_oxidase.
    [Graphical view ]
    PANTHERi PTHR13914. PTHR13914. 1 hit.
    Pfami PF01619. Pro_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51730. SSF51730. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
      Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Shinn P., Chen H., Cheuk R., Kim C.J., Carninci P., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M., Shinozaki K., Ecker J.R.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Two tobacco proline dehydrogenases are differentially regulated and play a role in early plant development."
      Ribarits A., Abdullaev A., Tashpulatov A., Richter A., Heberle-Bors E., Touraev A.
      Planta 225:1313-1324(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2."
      Hanson J., Hanssen M., Wiese A., Hendriks M.M., Smeekens S.
      Plant J. 53:935-949(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis."
      Funck D., Eckard S., Mueller G.
      BMC Plant Biol. 10:70-70(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPROD2_ARATH
    AccessioniPrimary (citable) accession number: Q6NKX1
    Secondary accession number(s): Q9FKR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3