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Protein

Probable protein phosphatase 2C 65

Gene

At5g01700

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Manganese 1By similarity1
Metal bindingi83Manganese 2By similarity1
Metal bindingi84Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi282Manganese 2By similarity1
Metal bindingi328Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-70895 Branched-chain amino acid catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 65 (EC:3.1.3.16)
Short name:
AtPP2C65
Gene namesi
Ordered Locus Names:At5g01700
ORF Names:F7A7.220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G01700
TAIRilocus:2149775 AT5G01700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679871 – 382Probable protein phosphatase 2C 65Add BLAST382

Proteomic databases

PaxDbiQ6NKS1
PRIDEiQ6NKS1

Expressioni

Gene expression databases

ExpressionAtlasiQ6NKS1 baseline and differential
GenevisibleiQ6NKS1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G01700.2

Structurei

3D structure databases

ProteinModelPortaliQ6NKS1
SMRiQ6NKS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 337PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
HOGENOMiHOG000233897
InParanoidiQ6NKS1
OMAiASWEGCF
OrthoDBiEOG09360B91
PhylomeDBiQ6NKS1

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NKS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVCCSKGTG IIVEHGADDG NECGDGEAEV RDTNDGAVVR TRGSSKHVSM
60 70 80 90 100
SIKQGKKGIN QDAMTVWENF GGEEDTIFCG VFDGHGPMGH KISRHVCENL
110 120 130 140 150
PSRVHSKIRS SKSAGDENIE NNSSQSQEEL FREFEDILVT FFKQIDSELG
160 170 180 190 200
LDSPYDSFCS GTTAVTVFKQ ADCLVIANLG HSRAVLGTRS KNSFKAVQLT
210 220 230 240 250
VDLKPCVQRE AERIVSCKGR VFAMEEEPDV YRVWMPDDDC PGLAMSRAFG
260 270 280 290 300
DFCLKDYGLV CIPDVFCRKV SREDEFVVLA TDGIWDVLSN EEVVKVVGSC
310 320 330 340 350
KDRSVAAEML VQRAARTWRT KFPASKADDC AVVVLYLNHR PYPREGNVSR
360 370 380
AISTISWRSN KSNNECYGAA PLSPLGLSQR VS
Length:382
Mass (Da):42,004
Last modified:July 5, 2004 - v1
Checksum:i27DA3A16DE5E77CA
GO
Isoform 2 (identifier: Q6NKS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):37,045
Checksum:i497A7EE74B9A0F6D
GO

Sequence cautioni

The sequence BX831823 differs from that shown. Sequencing errors.Curated
The sequence CAB82286 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367761 – 49Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161946 Genomic DNA Translation: CAB82286.1 Sequence problems.
CP002688 Genomic DNA Translation: AED90378.1
CP002688 Genomic DNA Translation: AED90379.1
BX831823 mRNA No translation available.
BT011618 mRNA Translation: AAS47624.1
BT012622 mRNA Translation: AAT06441.1
PIRiT48191
RefSeqiNP_001031819.1, NM_001036742.2 [Q6NKS1-1]
NP_195790.4, NM_120248.5 [Q6NKS1-2]
UniGeneiAt.33516

Genome annotation databases

EnsemblPlantsiAT5G01700.1; AT5G01700.1; AT5G01700 [Q6NKS1-2]
AT5G01700.2; AT5G01700.2; AT5G01700 [Q6NKS1-1]
GeneIDi831695
GrameneiAT5G01700.1; AT5G01700.1; AT5G01700 [Q6NKS1-2]
AT5G01700.2; AT5G01700.2; AT5G01700 [Q6NKS1-1]
KEGGiath:AT5G01700

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2C65_ARATH
AccessioniPrimary (citable) accession number: Q6NKS1
Secondary accession number(s): Q2V3A9, Q9M006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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