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Q6NKS1

- P2C65_ARATH

UniProt

Q6NKS1 - P2C65_ARATH

Protein

Probable protein phosphatase 2C 65

Gene

At5g01700

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Manganese 1By similarity
    Metal bindingi83 – 831Manganese 2By similarity
    Metal bindingi84 – 841Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi282 – 2821Manganese 2By similarity
    Metal bindingi328 – 3281Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G01700-MONOMER.
    ARA:GQT-1503-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 65 (EC:3.1.3.16)
    Short name:
    AtPP2C65
    Gene namesi
    Ordered Locus Names:At5g01700
    ORF Names:F7A7.220
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G01700.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Probable protein phosphatase 2C 65PRO_0000367987Add
    BLAST

    Proteomic databases

    PRIDEiQ6NKS1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6NKS1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NKS1.
    SMRiQ6NKS1. Positions 43-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 314269PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233897.
    InParanoidiQ6NKS1.
    OMAiISTISWR.
    PhylomeDBiQ6NKS1.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NKS1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVCCSKGTG IIVEHGADDG NECGDGEAEV RDTNDGAVVR TRGSSKHVSM    50
    SIKQGKKGIN QDAMTVWENF GGEEDTIFCG VFDGHGPMGH KISRHVCENL 100
    PSRVHSKIRS SKSAGDENIE NNSSQSQEEL FREFEDILVT FFKQIDSELG 150
    LDSPYDSFCS GTTAVTVFKQ ADCLVIANLG HSRAVLGTRS KNSFKAVQLT 200
    VDLKPCVQRE AERIVSCKGR VFAMEEEPDV YRVWMPDDDC PGLAMSRAFG 250
    DFCLKDYGLV CIPDVFCRKV SREDEFVVLA TDGIWDVLSN EEVVKVVGSC 300
    KDRSVAAEML VQRAARTWRT KFPASKADDC AVVVLYLNHR PYPREGNVSR 350
    AISTISWRSN KSNNECYGAA PLSPLGLSQR VS 382
    Length:382
    Mass (Da):42,004
    Last modified:July 5, 2004 - v1
    Checksum:i27DA3A16DE5E77CA
    GO
    Isoform 2 (identifier: Q6NKS1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:333
    Mass (Da):37,045
    Checksum:i497A7EE74B9A0F6D
    GO

    Sequence cautioni

    The sequence BX831823 differs from that shown. Reason: Sequencing errors.
    The sequence CAB82286.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_036776Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161946 Genomic DNA. Translation: CAB82286.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED90378.1.
    CP002688 Genomic DNA. Translation: AED90379.1.
    BX831823 mRNA. No translation available.
    BT011618 mRNA. Translation: AAS47624.1.
    BT012622 mRNA. Translation: AAT06441.1.
    PIRiT48191.
    RefSeqiNP_001031819.1. NM_001036742.1. [Q6NKS1-1]
    NP_195790.4. NM_120248.4. [Q6NKS1-2]
    UniGeneiAt.33516.

    Genome annotation databases

    EnsemblPlantsiAT5G01700.2; AT5G01700.2; AT5G01700. [Q6NKS1-1]
    GeneIDi831695.
    KEGGiath:AT5G01700.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161946 Genomic DNA. Translation: CAB82286.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED90378.1 .
    CP002688 Genomic DNA. Translation: AED90379.1 .
    BX831823 mRNA. No translation available.
    BT011618 mRNA. Translation: AAS47624.1 .
    BT012622 mRNA. Translation: AAT06441.1 .
    PIRi T48191.
    RefSeqi NP_001031819.1. NM_001036742.1. [Q6NKS1-1 ]
    NP_195790.4. NM_120248.4. [Q6NKS1-2 ]
    UniGenei At.33516.

    3D structure databases

    ProteinModelPortali Q6NKS1.
    SMRi Q6NKS1. Positions 43-338.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6NKS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G01700.2 ; AT5G01700.2 ; AT5G01700 . [Q6NKS1-1 ]
    GeneIDi 831695.
    KEGGi ath:AT5G01700.

    Organism-specific databases

    TAIRi AT5G01700.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233897.
    InParanoidi Q6NKS1.
    OMAi ISTISWR.
    PhylomeDBi Q6NKS1.

    Enzyme and pathway databases

    BioCyci ARA:AT5G01700-MONOMER.
    ARA:GQT-1503-MONOMER.

    Gene expression databases

    Genevestigatori Q6NKS1.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
      Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
      Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C65_ARATH
    AccessioniPrimary (citable) accession number: Q6NKS1
    Secondary accession number(s): Q2V3A9, Q9M006
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3