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Q6NKS1

- P2C65_ARATH

UniProt

Q6NKS1 - P2C65_ARATH

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Protein
Probable protein phosphatase 2C 65
Gene
At5g01700, F7A7.220
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Manganese 1 By similarity
Metal bindingi83 – 831Manganese 2 By similarity
Metal bindingi84 – 841Manganese 1; via carbonyl oxygen By similarity
Metal bindingi282 – 2821Manganese 2 By similarity
Metal bindingi328 – 3281Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01700-MONOMER.
ARA:GQT-1503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 65 (EC:3.1.3.16)
Short name:
AtPP2C65
Gene namesi
Ordered Locus Names:At5g01700
ORF Names:F7A7.220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G01700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Probable protein phosphatase 2C 65
PRO_0000367987Add
BLAST

Proteomic databases

PRIDEiQ6NKS1.

Expressioni

Gene expression databases

GenevestigatoriQ6NKS1.

Structurei

3D structure databases

ProteinModelPortaliQ6NKS1.
SMRiQ6NKS1. Positions 43-338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 314269PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233897.
InParanoidiQ6NKS1.
OMAiISTISWR.
PhylomeDBiQ6NKS1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NKS1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGVCCSKGTG IIVEHGADDG NECGDGEAEV RDTNDGAVVR TRGSSKHVSM    50
SIKQGKKGIN QDAMTVWENF GGEEDTIFCG VFDGHGPMGH KISRHVCENL 100
PSRVHSKIRS SKSAGDENIE NNSSQSQEEL FREFEDILVT FFKQIDSELG 150
LDSPYDSFCS GTTAVTVFKQ ADCLVIANLG HSRAVLGTRS KNSFKAVQLT 200
VDLKPCVQRE AERIVSCKGR VFAMEEEPDV YRVWMPDDDC PGLAMSRAFG 250
DFCLKDYGLV CIPDVFCRKV SREDEFVVLA TDGIWDVLSN EEVVKVVGSC 300
KDRSVAAEML VQRAARTWRT KFPASKADDC AVVVLYLNHR PYPREGNVSR 350
AISTISWRSN KSNNECYGAA PLSPLGLSQR VS 382
Length:382
Mass (Da):42,004
Last modified:July 5, 2004 - v1
Checksum:i27DA3A16DE5E77CA
GO
Isoform 2 (identifier: Q6NKS1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:333
Mass (Da):37,045
Checksum:i497A7EE74B9A0F6D
GO

Sequence cautioni

The sequence BX831823 differs from that shown. Reason: Sequencing errors.
The sequence CAB82286.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2.
VSP_036776Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161946 Genomic DNA. Translation: CAB82286.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90378.1.
CP002688 Genomic DNA. Translation: AED90379.1.
BX831823 mRNA. No translation available.
BT011618 mRNA. Translation: AAS47624.1.
BT012622 mRNA. Translation: AAT06441.1.
PIRiT48191.
RefSeqiNP_001031819.1. NM_001036742.1. [Q6NKS1-1]
NP_195790.4. NM_120248.4. [Q6NKS1-2]
UniGeneiAt.33516.

Genome annotation databases

EnsemblPlantsiAT5G01700.2; AT5G01700.2; AT5G01700. [Q6NKS1-1]
GeneIDi831695.
KEGGiath:AT5G01700.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161946 Genomic DNA. Translation: CAB82286.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED90378.1 .
CP002688 Genomic DNA. Translation: AED90379.1 .
BX831823 mRNA. No translation available.
BT011618 mRNA. Translation: AAS47624.1 .
BT012622 mRNA. Translation: AAT06441.1 .
PIRi T48191.
RefSeqi NP_001031819.1. NM_001036742.1. [Q6NKS1-1 ]
NP_195790.4. NM_120248.4. [Q6NKS1-2 ]
UniGenei At.33516.

3D structure databases

ProteinModelPortali Q6NKS1.
SMRi Q6NKS1. Positions 43-338.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6NKS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G01700.2 ; AT5G01700.2 ; AT5G01700 . [Q6NKS1-1 ]
GeneIDi 831695.
KEGGi ath:AT5G01700.

Organism-specific databases

TAIRi AT5G01700.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233897.
InParanoidi Q6NKS1.
OMAi ISTISWR.
PhylomeDBi Q6NKS1.

Enzyme and pathway databases

BioCyci ARA:AT5G01700-MONOMER.
ARA:GQT-1503-MONOMER.

Gene expression databases

Genevestigatori Q6NKS1.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C65_ARATH
AccessioniPrimary (citable) accession number: Q6NKS1
Secondary accession number(s): Q2V3A9, Q9M006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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