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Q6NKK9 (Q6NKK9_CORDI) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL CAE48520.1
Ordered Locus Names:DIP0009
OrganismCorynebacterium diphtheriae [Complete proteome] [HAMAP]
Taxonomic identifier1717 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q6NKK9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A7A46224E264DFAD

FASTA85694,910
        10         20         30         40         50         60 
MSDDLLGGDG YDRVHPIDLN EEMETSYIDY AMSVIVGRAL PEVRDGLKPV HRRILYAMYD 

        70         80         90        100        110        120 
SGYRPDRSYV KSARPVSDTM GQFHPHGDSA IYDTLVRLAQ DWNMRYPMVD GQGNFGSRGN 

       130        140        150        160        170        180 
DGPAAMRYTE CRLTPLAMEM VRDIRENTVD FSPNYDGKTQ EPDVLPSRVP NLLMNGSNGI 

       190        200        210        220        230        240 
AVGMATNIPP HNLRELGDAI FWLLDNPEAD EASALEACMK YVKGPDFPTA GQIVGSQGIN 

       250        260        270        280        290        300 
DAYTTGRGSI RMRGVTSIEE EGNRQIIVIT ELPYQVNPDN MISNIAEQVR DGKLAGISKI 

       310        320        330        340        350        360 
EDESSDRVGM RIVVTLKRDA VPRVVLNNLY KHSQLQTNFG ANMLSIVDGV PRTLRLDQML 

       370        380        390        400        410        420 
RHYVTHQIEV IVRRTQYRLD EAEKRAHILR GLVKALDMLD EVIALIRRSP TVDIARTGLM 

       430        440        450        460        470        480 
ELLTVDEIQA DAILAMQLRR LAALERQKIV DELAEIELEI ADYKDILARP ERQRAIVRDE 

       490        500        510        520        530        540 
LAEIVDKYGD DRRTQIIAAT GDVTEEDLIA RENVVVTITS TGYAKRTKVD AYKSQRRGGK 

       550        560        570        580        590        600 
GVRGAELKQD DVVRHFFVSS THDWILFFTN FGRVYRLKAY ELPEASRTAR GQHVANLLEF 

       610        620        630        640        650        660 
QPEERIAQVI QIQSYEDAPY LVLATAQGRV KKSRLSDYES NRSGGLIAIN LNEGDKLIGA 

       670        680        690        700        710        720 
ALCDNDDDLL LVSEEGQSIR FNANDDQLRP MGRATAGVKG MRFKGDDQLL AMTVVKPDAF 

       730        740        750        760        770        780 
LLVATSGGYG KRTSLDEYSP QGRGGQGVLT FKYTPKRGKL IAAVVVDEDD EILAITSAGG 

       790        800        810        820        830        840 
VIRTVVNQIR PSSRATMGVR LVNLEDGVEL LAIDRNVEGE GEEAAEAVAT GAVDGPAERG 

       850 
KQTEVDLGID NADEEA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248354 Genomic DNA. Translation: CAE48520.1.
RefSeqNP_938418.1. NC_002935.2.

3D structure databases

HSSPHSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortalQ6NKK9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2648827.
GenomeReviewsGene locus DIP0009 in contig BX248353_GR.
KEGGcdi:DIP0009.
NMPDRfig|257309.1.peg.9.
PATRIC21481181. VBICorDip47633_0010.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG635183.
OMATGRGRIY.
PhylomeDBQ6NKK9.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ6NKK9_CORDI
AccessionPrimary (citable) accession number: Q6NKK9
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info