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Protein
Submitted name:

Diphtheria toxin

Gene

tox

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. NAD+-diphthamide ADP-ribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Diphtheria toxinImported (EC:2.4.2.36Imported)
Gene namesi
Name:toxImported
Ordered Locus Names:DIP0222Imported
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)Imported
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7700183,EBI-7700183

Protein-protein interaction databases

MINTiMINT-7298372.
STRINGi257309.DIP0222.

Structurei

3D structure databases

ProteinModelPortaliQ6NK15.
SMRiQ6NK15. Positions 26-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK00776.

Family and domain databases

Gene3Di1.10.490.40. 1 hit.
2.60.40.700. 1 hit.
InterProiIPR000512. Diphtheria_toxin.
IPR022406. Diphtheria_toxin_catalytic_dom.
IPR022404. Diphtheria_toxin_rcpt-bd_dom.
IPR022405. Diphtheria_toxin_translocation.
[Graphical view]
PfamiPF02763. Diphtheria_C. 1 hit.
PF01324. Diphtheria_R. 1 hit.
PF02764. Diphtheria_T. 1 hit.
[Graphical view]
PIRSFiPIRSF000490. Diphtheria_toxin. 1 hit.
PRINTSiPR00769. DPTHRIATOXIN.
SUPFAMiSSF49380. SSF49380. 1 hit.
SSF56845. SSF56845. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NK15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKLFASIL IGALLGIGAP PSAHAGADDV VDSSKSFVME NFSSYHGTKP
60 70 80 90 100
GYVDSIQKGI QKPKSGTQGN YDDDWKGFYS TDNKYDAAGY SVDNENPLSG
110 120 130 140 150
KAGGVVKVTY PGLTKVLALK VDNAETIKKE LGLSLTEPLM EQVGTEEFIK
160 170 180 190 200
RFGDGASRVV LSLPFAEGSS SVEYINNWEQ AKALSVELEI NFETRGKRGQ
210 220 230 240 250
DAMYEYMAQA CAGNRVRRSV GSSLSCINLD WDVIRDKTKT KIESLKEHGP
260 270 280 290 300
IKNKMSESPN KTVSEEKAKQ YLEEFHQTAL EHPELSELKT VTGTNPVFAG
310 320 330 340 350
ANYAAWAVNV AQVIDSETAD NLEKTTAALS ILPGIGSVMG IADGAVHHNT
360 370 380 390 400
EEIVAQSIAL SSLMVAQAIP LVGELVDIGF AAYNFVESII NLFQVVHNSY
410 420 430 440 450
NRPAYSPGHK TQPFLHDGYA VSWNTVEDSI IRTGFQGESG HDIKITAENT
460 470 480 490 500
PLPIAGVLLP TIPGKLDVNK SKTHISVNGR KIRMRCRAID GDVTFCRPKS
510 520 530 540 550
PVYVGNGVHA NLHVAFHRSS SEKIHSNEIS SDSIGVLGYQ KTVDHTKVNS
560
KLSLFFEIKS
Length:560
Mass (Da):60,815
Last modified:July 4, 2004 - v1
Checksum:i51F5718361B94EAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248354 Genomic DNA. Translation: CAE48728.1.
RefSeqiNP_938615.1. NC_002935.2.
WP_003850266.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE48728; CAE48728; DIP0222.
GeneIDi23332460.
KEGGicdi:DIP0222.
PATRICi21481599. VBICorDip47633_0209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248354 Genomic DNA. Translation: CAE48728.1.
RefSeqiNP_938615.1. NC_002935.2.
WP_003850266.1. NC_002935.2.

3D structure databases

ProteinModelPortaliQ6NK15.
SMRiQ6NK15. Positions 26-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-7298372.
STRINGi257309.DIP0222.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE48728; CAE48728; DIP0222.
GeneIDi23332460.
KEGGicdi:DIP0222.
PATRICi21481599. VBICorDip47633_0209.

Phylogenomic databases

KOiK00776.

Family and domain databases

Gene3Di1.10.490.40. 1 hit.
2.60.40.700. 1 hit.
InterProiIPR000512. Diphtheria_toxin.
IPR022406. Diphtheria_toxin_catalytic_dom.
IPR022404. Diphtheria_toxin_rcpt-bd_dom.
IPR022405. Diphtheria_toxin_translocation.
[Graphical view]
PfamiPF02763. Diphtheria_C. 1 hit.
PF01324. Diphtheria_R. 1 hit.
PF02764. Diphtheria_T. 1 hit.
[Graphical view]
PIRSFiPIRSF000490. Diphtheria_toxin. 1 hit.
PRINTSiPR00769. DPTHRIATOXIN.
SUPFAMiSSF49380. SSF49380. 1 hit.
SSF56845. SSF56845. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravisImported.

Entry informationi

Entry nameiQ6NK15_CORDI
AccessioniPrimary (citable) accession number: Q6NK15
Entry historyi
Integrated into UniProtKB/TrEMBL: July 4, 2004
Last sequence update: July 4, 2004
Last modified: March 31, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.