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Protein
Submitted name:

Diphtheria toxin

Gene

tox

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionGlycosyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Diphtheria toxinImported (EC:2.4.2.36Imported)
Gene namesi
Name:toxImported
Ordered Locus Names:DIP0222Imported
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)Imported
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500427912326 – 560Sequence analysisAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi211 ↔ 226Combined sources
Disulfide bondi486 ↔ 496Combined sources

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7700183,EBI-7700183

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-7298372.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I82X-ray2.35A/B/C/D26-560[»]
ProteinModelPortaliQ6NK15.
SMRiQ6NK15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 212Diphtheria_CInterPro annotationAdd BLAST187
Domaini225 – 404Diphtheria_TInterPro annotationAdd BLAST180
Domaini406 – 559Diphtheria_RInterPro annotationAdd BLAST154

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK00776.

Family and domain databases

Gene3Di1.10.490.40. 1 hit.
2.60.40.700. 1 hit.
InterProiView protein in InterPro
IPR036799. Diphtheria_tox_rcpt-bd_dom_sf.
IPR036801. Diphtheria_tox_transloc_sf.
IPR000512. Diphtheria_toxin.
IPR022406. Diphtheria_toxin_catalytic_dom.
IPR022404. Diphtheria_toxin_rcpt-bd_dom.
IPR022405. Diphtheria_toxin_translocation.
PfamiView protein in Pfam
PF02763. Diphtheria_C. 1 hit.
PF01324. Diphtheria_R. 1 hit.
PF02764. Diphtheria_T. 1 hit.
PIRSFiPIRSF000490. Diphtheria_toxin. 1 hit.
PRINTSiPR00769. DPTHRIATOXIN.
SUPFAMiSSF49380. SSF49380. 1 hit.
SSF56845. SSF56845. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NK15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKLFASIL IGALLGIGAP PSAHAGADDV VDSSKSFVME NFSSYHGTKP
60 70 80 90 100
GYVDSIQKGI QKPKSGTQGN YDDDWKGFYS TDNKYDAAGY SVDNENPLSG
110 120 130 140 150
KAGGVVKVTY PGLTKVLALK VDNAETIKKE LGLSLTEPLM EQVGTEEFIK
160 170 180 190 200
RFGDGASRVV LSLPFAEGSS SVEYINNWEQ AKALSVELEI NFETRGKRGQ
210 220 230 240 250
DAMYEYMAQA CAGNRVRRSV GSSLSCINLD WDVIRDKTKT KIESLKEHGP
260 270 280 290 300
IKNKMSESPN KTVSEEKAKQ YLEEFHQTAL EHPELSELKT VTGTNPVFAG
310 320 330 340 350
ANYAAWAVNV AQVIDSETAD NLEKTTAALS ILPGIGSVMG IADGAVHHNT
360 370 380 390 400
EEIVAQSIAL SSLMVAQAIP LVGELVDIGF AAYNFVESII NLFQVVHNSY
410 420 430 440 450
NRPAYSPGHK TQPFLHDGYA VSWNTVEDSI IRTGFQGESG HDIKITAENT
460 470 480 490 500
PLPIAGVLLP TIPGKLDVNK SKTHISVNGR KIRMRCRAID GDVTFCRPKS
510 520 530 540 550
PVYVGNGVHA NLHVAFHRSS SEKIHSNEIS SDSIGVLGYQ KTVDHTKVNS
560
KLSLFFEIKS
Length:560
Mass (Da):60,815
Last modified:July 5, 2004 - v1
Checksum:i51F5718361B94EAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248354 Genomic DNA. Translation: CAE48728.1.
RefSeqiWP_003850266.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE48728; CAE48728; DIP0222.
KEGGicdi:DIP0222.

Similar proteinsi

Entry informationi

Entry nameiQ6NK15_CORDI
AccessioniPrimary (citable) accession number: Q6NK15
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported