Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6NJJ4 (DCUP_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:DIP0407
OrganismCorynebacterium diphtheriae [Complete proteome] [HAMAP]
Taxonomic identifier1717 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325634

Regions

Region26 – 305Substrate binding By similarity

Sites

Binding site751Substrate By similarity
Binding site1501Substrate By similarity
Binding site2051Substrate By similarity
Binding site3231Substrate By similarity
Site751Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NJJ4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CEE3113771FF3EEE

FASTA34437,972
        10         20         30         40         50         60 
MVSMPNPILD AAAGVTPHRR PVWFMRQAGR SLPEYREIRE GVSMLDSCFR PDMLAEITLQ 

        70         80         90        100        110        120 
PVRRHDVDAA ILFSDIVVPL KAAGVRVEIV PGRGPVMDHP LLTRQDIENL PILDHDVHEV 

       130        140        150        160        170        180 
AEGIGIIREE LNDAQTLIGF AGAPFTLASY LVEGGPSKNH EKTKSLMHQD PESWHLLMRR 

       190        200        210        220        230        240 
LVPTIVQFLR TQIDAGVQAM QLFDSWAGFL SERDYREFVL PYSMEILAQV GDVPRIHFGV 

       250        260        270        280        290        300 
GTGELLTAMS EAGSEVVGVD WRVPLDVAAQ RMVSPKVLQG NLDPAILFAG EDVMRREIAR 

       310        320        330        340 
ICAEADRAIA AGHATGHIFN LGHGVLPNTD PDAITRAVEI IHTF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248355 Genomic DNA. Translation: CAE48911.1.
RefSeqNP_938788.1. NC_002935.2.

3D structure databases

HSSPHSSP built from PDB template 1R3S based on UniProtKB P06132.
ProteinModelPortalQ6NJJ4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2649507.
GenomeReviewsGene locus DIP0407 in contig BX248353_GR.
KEGGcdi:DIP0407.
NMPDRfig|257309.1.peg.379.
PATRIC21481971. VBICorDip47633_0390.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ6NJJ4.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycCDIP257309:DIP0407-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CORDI
AccessionPrimary (citable) accession number: Q6NJJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents