UniProtKB - Q6NJJ2 (GSA_CORDI)
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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Functioni
Catalytic activityi
(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotation
: protoporphyrin-IX biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Glutamyl-tRNA reductase (hemA)
- Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.
GO - Molecular functioni
- glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
- pyridoxal phosphate binding Source: InterPro
- transaminase activity Source: InterPro
GO - Biological processi
- protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Porphyrin biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00251; UER00317. |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)Short name: GSAUniRule annotation Alternative name(s): Glutamate-1-semialdehyde aminotransferaseUniRule annotation Short name: GSA-ATUniRule annotation |
Gene namesi | Name:hemLUniRule annotation Ordered Locus Names:DIP0409 |
Organismi | Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) |
Taxonomic identifieri | 257309 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Corynebacteriaceae › Corynebacterium › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120404 | 1 – 430 | Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST | 430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 267 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Interactioni
Subunit structurei
Homodimer.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | Q6NJJ2. |
SMRi | Q6NJJ2. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000020210. |
KOi | K01845. |
OMAi | WGPLIFG. |
Family and domain databases
CDDi | cd00610. OAT_like. 1 hit. |
Gene3Di | 3.40.640.10. 1 hit. 3.90.1150.10. 2 hits. |
HAMAPi | MF_00375. HemL_aminotrans_3. 1 hit. |
InterProi | View protein in InterPro IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015422. PyrdxlP-dep_Trfase_dom1. IPR015421. PyrdxlP-dep_Trfase_major. |
Pfami | View protein in Pfam PF00202. Aminotran_3. 1 hit. |
SUPFAMi | SSF53383. SSF53383. 1 hit. |
TIGRFAMsi | TIGR00713. hemL. 1 hit. |
PROSITEi | View protein in PROSITE PS00600. AA_TRANSFER_CLASS_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6NJJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSTQRSQEL FARAQQFTPG GVNSPVRAFG SVGGHARFIQ SAKGSKLYDV
60 70 80 90 100
DGNEYVDLVC SWGPMLLGNA HPEIVEAVQK AATNGLSFGA PTEAEVKIAE
110 120 130 140 150
MIVDRTSVEE VRMVNSGTEA TMSAVRLARG FTGRPKVIKF DGCYHGHVDA
160 170 180 190 200
LLASAGSGVA TFALPDSPGV TGASAADTIV VPYNDSEAVR AAFEAHPDQI
210 220 230 240 250
ACVIAEAAAG NMGTVAPQDN FNAKLKEVAH EHGALLILDE VMTGFRTSYN
260 270 280 290 300
GWYGVDGVAG DLTTFGKVIS GGLPAAAFGG RADIMRYLAP EGPVYQAGTL
310 320 330 340 350
SGNPVAMAAG MKSLELATPE VYDMVRANAD RLAGLLHEAL DREGVAHHIQ
360 370 380 390 400
RAATMLSVRF AEGEGHNFDD MKAADTFRFP AFFHALLDNG IYASPSVFET
410 420 430
WFVSAALTDD DFDKIEKALR PAAQAAGKAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248355 Genomic DNA. Translation: CAE48913.1. |
RefSeqi | WP_010934280.1. NC_002935.2. |
Genome annotation databases
EnsemblBacteriai | CAE48913; CAE48913; DIP0409. |
KEGGi | cdi:DIP0409. |
Similar proteinsi
Entry informationi
Entry namei | GSA_CORDI | |
Accessioni | Q6NJJ2Primary (citable) accession number: Q6NJJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 28, 2018 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |