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Q6NJH8

- MEND_CORDI

UniProt

Q6NJH8 - MEND_CORDI

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Protein
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Gene
menD, DIP0423
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity.UniRule annotation

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

Cofactori

Magnesium or manganese By similarity.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

UniPathwayiUPA00079; UER00164.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (EC:2.2.1.9)
Short name:
SEPHCHC synthase
Alternative name(s):
Menaquinone biosynthesis protein MenD
Gene namesi
Name:menD
Ordered Locus Names:DIP0423
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5095092-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation
PRO_0000341726Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257309.DIP0423.

Structurei

3D structure databases

ProteinModelPortaliQ6NJH8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1165.
HOGENOMiHOG000218359.
KOiK02551.
OMAiWRSAVCR.
OrthoDBiEOG6NWBQW.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01659. MenD.
InterProiIPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004983. MenD. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00173. menD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NJH8-1 [UniParc]FASTAAdd to Basket

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MTSSPELARA VAATLARHVT DVVICPGSRN SPLSLELIAR DDIRVHTRID    50
ERSAAFLALG LARSSKRHVA VVTTSGTAVA NCAPAMIEAA YSHTPLIMVS 100
ADRPERLHGT GANQTIEQRG IFNVVDTDHV VDITDLNSIS FARNVIHINV 150
ALDVPLVDVL PEVGDPVERV REVIEVDHGE VVLNLNERIL VVAGDEAWEV 200
PGLEDVPTIA EPSAPAPYHP VHPLAAQIFA HKEIKPEHIV VVGHPTLHRA 250
VLSLLADVPV TVLTKTDTIT GNPQAVGSRV KVTGELDKRW LQICEDASTL 300
CADRVKEVLE GHGFTGLHVA AAVADTMAVG DTLFLGASNP VRDASLVGMP 350
LGGVDIFAAR GAAGIDGTVS QAVGVALDVQ HRDATAIRAD RTVALMGDVT 400
FLHDVGGLLG ARPENLTIVV ANDDGCGIFE TLEIGAPEFR PSFEQAFGTP 450
HGVHIEAIAQ AYGVNYLRAE TLPELIEALI DTTDSAGFNI IEAVTTRSTR 500
RDIDKALTL 509
Length:509
Mass (Da):54,051
Last modified:July 5, 2004 - v1
Checksum:iBDD2B2DD303A2068
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248355 Genomic DNA. Translation: CAE48927.1.
RefSeqiNP_938804.1. NC_002935.2.
WP_010934292.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE48927; CAE48927; DIP0423.
GeneIDi2649096.
KEGGicdi:DIP0423.
PATRICi21482003. VBICorDip47633_0406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248355 Genomic DNA. Translation: CAE48927.1 .
RefSeqi NP_938804.1. NC_002935.2.
WP_010934292.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NJH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP0423.

Protocols and materials databases

DNASUi 2649096.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE48927 ; CAE48927 ; DIP0423 .
GeneIDi 2649096.
KEGGi cdi:DIP0423.
PATRICi 21482003. VBICorDip47633_0406.

Phylogenomic databases

eggNOGi COG1165.
HOGENOMi HOG000218359.
KOi K02551.
OMAi WRSAVCR.
OrthoDBi EOG6NWBQW.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00164 .

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01659. MenD.
InterProi IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
[Graphical view ]
Pfami PF02775. TPP_enzyme_C. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004983. MenD. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00173. menD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiMEND_CORDI
AccessioniPrimary (citable) accession number: Q6NJH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3