Q6NJC1 (RL5_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L5

Gene names

Name:	rplE
Ordered Locus Names:	DIP0488

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs By similarity. HAMAP MF_01333_B
Subunit structure	Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome By similarity.
Sequence similarities	Belongs to the ribosomal protein L5P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	50S ribosomal protein L5 HAMAP MF_01333_B		PRO_0000124919

Sequences

	Sequence		Length	Mass (Da)
	Q6NJC1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 95587C5DC239FB0C	FASTA	187	21,376
	10 20 30 40 50 60 MSENYTPRLK TRYREEIRTK LNDEFSYENV MQIPGVVKVV VNMGVGDAAR DSKLINGALE 70 80 90 100 110 120 DLTLITGQKP ELRRAKKSIA NFKLREGMPI GARVTLRGDR MWEFLDRLLT VALPRIRDFR 130 140 150 160 170 180 GLSDQQFDGH GNYTFGLSEQ TMFYEIDVDK IDRPRGMDIT VVTTATNNEE GRALLRELGF PFKKADA

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248355 Genomic DNA. Translation: CAE48999.1.
RefSeq	NP_938867.1. NC_002935.2.
3D structure databases
ProteinModelPortal	Q6NJC1.
SMR	Q6NJC1. Positions 9-184.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2649535.
GenomeReviews	Gene locus DIP0488 in contig BX248353_GR.
KEGG	cdi:DIP0488.
NMPDR	fig|257309.1.peg.458.
PATRIC	21482145. VBICorDip47633_0473.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG592167.
OMA	RQGMPIG.
PhylomeDB	Q6NJC1.
ProtClustDB	PRK00010.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP0488-MONOMER.
Family and domain databases
HAMAP	MF_01333_B. Ribosomal_L5_B. [Tree]
InterPro	IPR002132. Ribosomal_L5. IPR020930. Ribosomal_L5_bac-type. IPR022803. Ribosomal_L5_domain. [Graphical view]
Gene3D	G3DSA:3.30.1440.10. Ribosomal_L5. 1 hit.
KO	K02931.
PANTHER	PTHR11994. Ribosomal_L5. 1 hit.
Pfam	PF00281. Ribosomal_L5. 1 hit. PF00673. Ribosomal_L5_C. 1 hit. [Graphical view]
PIRSF	PIRSF002161. Ribosomal_L5. 1 hit.
SUPFAM	SSF55282. Ribosomal_L5. 1 hit.
PROSITE	PS00358. RIBOSOMAL_L5. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL5_CORDI

Accession

Primary (citable) accession number: Q6NJC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program