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Q6NIE5 (G6PI_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:DIP0832
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180631

Sites

Active site3551Proton donor By similarity
Active site3861 By similarity
Active site5121 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NIE5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 23FF0EEF84F3B559

FASTA54759,411
        10         20         30         40         50         60 
MSFDVTTTEP WATLSERYTA MKATTLRDLF ASNPNRAQEL SFEAAGLHVD LSKNLIDAET 

        70         80         90        100        110        120 
VAAFTALAKA SGMREKIKAM FDGEHINNTE DRAVLHTALR LAVDAELNVD GQDVAADVHE 

       130        140        150        160        170        180 
VLGRMRDFAT SLRNGSWRGY SNHTIKTIVN IGIGGSDLGP AMATKALRTY ATAGINAKFV 

       190        200        210        220        230        240 
SNVDPADMHA VLDELDPEST LFVVASKTFT TQETLANAHA AKRWLVAAAG GDESAVAKHF 

       250        260        270        280        290        300 
VAVSTNAEKV AEFGIDTKNM FGFWNWVGGR YSVDSAIGLS LMSVIGPMDF MRFLDGFRAM 

       310        320        330        340        350        360 
DEHFRTADFE SNIPVLMGML NVFYNDFFGA ETHAVLPYSQ DLGRFPAYLQ QLTMESNGKS 

       370        380        390        400        410        420 
VRHDGSAVTT NTGEIYWGEP GTNGQHAFFQ LIHQGTKLIP ADFIGFARPK EDLPTASGEG 

       430        440        450        460        470        480 
SMHDLLMSNF FAQTKVLAFG KTAEEIAAEG VSPELVAHKV MPGNRPTTTI MAEELTPFAL 

       490        500        510        520        530        540 
GALIALYEHI VFVEGVIWDI NSFDQWGVEL GKQQANDLAP AVAGEVAVDS GDSSTDALIS 


WYRSHRG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248356 Genomic DNA. Translation: CAE49348.1.
RefSeqNP_939196.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NIE5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP0832.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE49348; CAE49348; DIP0832.
GeneID2649294.
KEGGcdi:DIP0832.
PATRIC21482833. VBICorDip47633_0812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261371.
KOK01810.
OMAKVNMFAL.
OrthoDBEOG64R61J.
ProtClustDBPRK00179.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CORDI
AccessionPrimary (citable) accession number: Q6NIE5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways