Q6NIE5 (G6PI_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	DIP0832

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	547 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 547	547	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180631
Sites
	Active site	355	1	Proton donor By similarity
	Active site	386	1	By similarity
	Active site	512	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6NIE5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 23FF0EEF84F3B559	FASTA	547	59,411
	10 20 30 40 50 60 MSFDVTTTEP WATLSERYTA MKATTLRDLF ASNPNRAQEL SFEAAGLHVD LSKNLIDAET 70 80 90 100 110 120 VAAFTALAKA SGMREKIKAM FDGEHINNTE DRAVLHTALR LAVDAELNVD GQDVAADVHE 130 140 150 160 170 180 VLGRMRDFAT SLRNGSWRGY SNHTIKTIVN IGIGGSDLGP AMATKALRTY ATAGINAKFV 190 200 210 220 230 240 SNVDPADMHA VLDELDPEST LFVVASKTFT TQETLANAHA AKRWLVAAAG GDESAVAKHF 250 260 270 280 290 300 VAVSTNAEKV AEFGIDTKNM FGFWNWVGGR YSVDSAIGLS LMSVIGPMDF MRFLDGFRAM 310 320 330 340 350 360 DEHFRTADFE SNIPVLMGML NVFYNDFFGA ETHAVLPYSQ DLGRFPAYLQ QLTMESNGKS 370 380 390 400 410 420 VRHDGSAVTT NTGEIYWGEP GTNGQHAFFQ LIHQGTKLIP ADFIGFARPK EDLPTASGEG 430 440 450 460 470 480 SMHDLLMSNF FAQTKVLAFG KTAEEIAAEG VSPELVAHKV MPGNRPTTTI MAEELTPFAL 490 500 510 520 530 540 GALIALYEHI VFVEGVIWDI NSFDQWGVEL GKQQANDLAP AVAGEVAVDS GDSSTDALIS WYRSHRG

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248356 Genomic DNA. Translation: CAE49348.1.
RefSeq	NP_939196.1. NC_002935.2.
3D structure databases
ProteinModelPortal	Q6NIE5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2649294.
GenomeReviews	Gene locus DIP0832 in contig BX248353_GR.
KEGG	cdi:DIP0832.
NMPDR	fig|257309.1.peg.787.
PATRIC	21482833. VBICorDip47633_0812.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	VDEHFRN.
PhylomeDB	Q6NIE5.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP0832-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CORDI

Accession

Primary (citable) accession number: Q6NIE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program