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Q6NID8

- PUR9_CORDI

UniProt

Q6NID8 - PUR9_CORDI

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:DIP0839
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Bifunctional purine biosynthesis protein PurHPRO_1000096057Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP0839.

Structurei

3D structure databases

ProteinModelPortaliQ6NID8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NID8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDDRKQIKR ALISVYDKTG LEDLARALND AGVEIVSTGS TAAKIADLGV
60 70 80 90 100
PVTPVEQLTG FPECLEGRVK TLHPMVHAGI LADTRKEDHL KQLDELNVAP
110 120 130 140 150
FQLVVVNLYP FTQTVASGAD FDACVEQIDI GGPSMVRAAA KNHPSVAVVV
160 170 180 190 200
SPSRYSEIIA AVGNGGFTRA ERTALAVDAF RHTASYDVAV ATWMGEQIAD
210 220 230 240 250
ADKPFAEWIG ASYERANILR YGENPHQAAA LYTDPAAPAG LAQATQLHGK
260 270 280 290 300
EMSYNNYTDS DAAWRAAWDH ERPCVAIIKH ANPCGIAVSD VSIAEAHRTA
310 320 330 340 350
HACDPVSAFG GVIASNREVS VDMAKQVSEI FTEVIIAPSY EDGAVDILSQ
360 370 380 390 400
KKNIRILVAP QPQRDELEQR QISGGVLVQR RDLVDAEGDT PANWTLAAGE
410 420 430 440 450
GASEELLAEL EFAWRAVRAV KSNAILLAQG GATVGVGMGQ VNRVDAAKLA
460 470 480 490 500
VERANSLAGD EQRAKGSVAA SDAFFPFADG FEVLAQAGVR AVVQPGGSIR
510 520
DAEVIEAANK AGVTMYLTGA RHFAH
Length:525
Mass (Da):55,796
Last modified:July 5, 2004 - v1
Checksum:iFE36CC0946E9A82D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248356 Genomic DNA. Translation: CAE49355.1.
RefSeqiNP_939203.1. NC_002935.2.
WP_010934605.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE49355; CAE49355; DIP0839.
GeneIDi2649301.
KEGGicdi:DIP0839.
PATRICi21482849. VBICorDip47633_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248356 Genomic DNA. Translation: CAE49355.1 .
RefSeqi NP_939203.1. NC_002935.2.
WP_010934605.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NID8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP0839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE49355 ; CAE49355 ; DIP0839 .
GeneIDi 2649301.
KEGGi cdi:DIP0839.
PATRICi 21482849. VBICorDip47633_0820.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiPUR9_CORDI
AccessioniPrimary (citable) accession number: Q6NID8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3