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Protein

HTH-type transcriptional regulator RipA

Gene

ripA

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi120 – 16647H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi172 – 21544H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator RipABy similarity
Alternative name(s):
Repressor of iron proteins ABy similarity
Short name:
RIPABy similarity
Gene namesi
Name:ripABy similarity
Ordered Locus Names:DIP0922
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335HTH-type transcriptional regulator RipAPRO_0000223237Add
BLAST

Expressioni

Inductioni

Repressed by DtxR under iron excess.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6NI56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000263853.
OMAiHPSECIA.
OrthoDBiEOG683S6N.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NI56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPSIKTTN SYCVVLWCDQ GSATINAPDR VVQVMAGDVV LAPHGAFVTG
60 70 80 90 100
HGVVLPMAFP DFDGGEHTRR LHMGTAWSKR MIFEFSRSLL GETRPSECIA
110 120 130 140 150
ALFDDRARPP RVPEPQAARK VAQKLIAYPA DQTPLLEFAQ LHNISSRTLQ
160 170 180 190 200
RQFVASTGFT FSEWRAALRV SVAADLLAHD FRIGQVSQMV GFSATSSLTR
210 220 230 240 250
AFKRHTGDTP SSFTSPRMHA VCEQQPPMIP ATTTFARASD DIALWIYSGT
260 270 280 290 300
ATVTTPGYCR FMGAGETVTI PSGTSTRLDV SAGSVALPVP LAAAHDDLTL
310 320 330
SDVLAASVNP LAAVELQRLS AQERADVEQV LVPSV
Length:335
Mass (Da):36,067
Last modified:July 5, 2004 - v1
Checksum:i303003C3FF02B969
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248356 Genomic DNA. Translation: CAE49439.1.
RefSeqiWP_010934672.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE49439; CAE49439; DIP0922.
GeneIDi2649962.
KEGGicdi:DIP0922.
PATRICi21483017. VBICorDip47633_0902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248356 Genomic DNA. Translation: CAE49439.1.
RefSeqiWP_010934672.1. NC_002935.2.

3D structure databases

ProteinModelPortaliQ6NI56.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi2649962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE49439; CAE49439; DIP0922.
GeneIDi2649962.
KEGGicdi:DIP0922.
PATRICi21483017. VBICorDip47633_0902.

Phylogenomic databases

HOGENOMiHOG000263853.
OMAiHPSECIA.
OrthoDBiEOG683S6N.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiRIPA_CORDI
AccessioniPrimary (citable) accession number: Q6NI56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.