Q6NI48 (COAA_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	DIP0931

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Pantothenate kinase HAMAP MF_00215		PRO_0000325548
Regions
	Nucleotide binding	93 – 100	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6NI48 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F0635FBB3A91A1D7	FASTA	308	35,233
	10 20 30 40 50 60 MARDKDLSPY LDFDRETWRH LRMSMPQVLT EQEVVELRGI GENIDLDEVA EVYLPLSRLI 70 80 90 100 110 120 HLQVHARQEL TQATETFLGE KAPHIPFVIG VAGSVAVGKS TTARLLQVLL QRWDEHPRVD 130 140 150 160 170 180 LVTTDGFLHP TEILKKRGIL DRKGFPESYD QRALLRFVTD VKAGKAHVKA PVYSHTLYDR 190 200 210 220 230 240 VENECVTVSR PDILIVEGLN VLQTGPTLSV SDLFDFSVYV DAALEDIERW YIDRFLKLRQ 250 260 270 280 290 300 LAFRAPNAHF SHYADMGDRA ATDEARRIWQ TINLPNLVEH ILPTRVRASL VLCKGADHKV ARVRMRKI

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248356 Genomic DNA. Translation: CAE49450.1.
RefSeq	NP_939294.1. NC_002935.2.
3D structure databases
HSSP	HSSP built from PDB template 1ESM based on UniProtKB P0A6I3.
ProteinModelPortal	Q6NI48.
SMR	Q6NI48. Positions 8-308.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2649971.
GenomeReviews	Gene locus DIP0931 in contig BX248353_GR.
KEGG	cdi:DIP0931.
NMPDR	fig|257309.1.peg.885.
PATRIC	21483037. VBICorDip47633_0912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q6NI48.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP0931-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_CORDI

Accession

Primary (citable) accession number: Q6NI48

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program