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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15ZincUniRule annotation1
Metal bindingi18ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:DIP0971
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001761 – 2931D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST293

Structurei

3D structure databases

ProteinModelPortaliQ6NI09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241173
KOiK15525
OMAiKFYWTVT

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
HAMAPiMF_01696 MshB, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
IPR017810 Mycothiol_biosynthesis_MshB
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit
TIGRFAMsiTIGR03445 mycothiol_MshB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NI09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDLIGFKAV AVHAHPDDEA IWTGGLLANL AARGADVTVV TCTLGEEGEV
60 70 80 90 100
IGEPYQGLTN KNADQLGGFR IHELHKSLSL LGVRGEFLGG AGCWRDSGMI
110 120 130 140 150
GDPANEHPRA FISSGDKSIE QLTEIFERLQ PDLVITYGPD GGYGHPDHIR
160 170 180 190 200
AHNITHTVAE NMDIPRILWA VTPRTELEQG MAAITTLPSG WRRALPGEVA
210 220 230 240 250
CVDHVDLTIA LDDHAFAAKA AAMRAHATQL WLADATISDV NPHAAIAGVA
260 270 280 290
DPKAAPLVFA LSNLIAQPLL DIECYQLGGG TPLTSNDPTE GIR
Length:293
Mass (Da):31,202
Last modified:July 5, 2004 - v1
Checksum:i3731EA7A9DD5D026
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248356 Genomic DNA Translation: CAE49489.1
RefSeqiWP_010934705.1, NC_002935.2

Genome annotation databases

EnsemblBacteriaiCAE49489; CAE49489; DIP0971
GeneIDi29423117
KEGGicdi:DIP0971

Similar proteinsi

Entry informationi

Entry nameiMSHB_CORDI
AccessioniPrimary (citable) accession number: Q6NI09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health