Q6NHX8 (Q6NHX8_CORDI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
2-oxoglutarate dehydrogenase, E1 and E2 components EMBL CAE49520.1
EC=1.2.4.2 EMBL CAE49520.1
EC=2.3.1.61 EMBL CAE49520.1

Gene names

Name:	odhA EMBL CAE49520.1
Ordered Locus Names:	DIP1002

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	1243 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423

Ontologies

Keywords
Ligand	Thiamine pyrophosphate SAAS SAAS001017
Molecular function	Acyltransferase EMBL CAE49520.1 Oxidoreductase EMBL CAE49520.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	dihydrolipoyllysine-residue succinyltransferase activity Inferred from electronic annotation. Source: EC oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6NHX8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 705D802F5576C596	FASTA	1,243	137,146
	10 20 30 40 50 60 MRRAPAVSSA STFGQNDWLV DEMFQQFQKD PQSVDKEWRD LFEKQGAPST PGTEAKNTSP 70 80 90 100 110 120 QPAAPAKKQP APAKKPAPTT ASAPASTEAK AAPKPENKKP AKKQQPSPLE RTGELPAAGS 130 140 150 160 170 180 SAIKGIYKAI AKNMDESLEV PTATTVRDMP VKLMWENRSI INEHLKRTTG GKVSFTHIIG 190 200 210 220 230 240 YAVVKATMAH PDMNNYYEVV DGKPTLNTPE HINMGLAIDV QQKSGARALV VAAIKEAETL 250 260 270 280 290 300 SFAEFVAKYE DIVARSRVGK LTMDDYSGVT ISLTNPGGIG TRHSVPRLTK GQGAIIGVGS 310 320 330 340 350 360 MDYPAEFAGA SADRLAELGV GRLVTITSTY DHRIIQGAES GEFLRTMSQL FIDDAFWDEI 370 380 390 400 410 420 FESIGIPYAP MRWASDLSNT GIDKNTRVMQ LIEAYRSRGH LIADTNPLRW HQPGMPVPDH 430 440 450 460 470 480 RDLDIATHGL TLWDLDRSFN VGGFGGKETM TLREVLGRLR AAYTLKVGSE YTHILDRDER 490 500 510 520 530 540 LWLQDRIEAG MPKPSYAEQK YILQKLNAAQ AFEDFLQTKY VGQKRFSLEG AEALIPLMDS 550 560 570 580 590 600 AIDTAAGQGL DEVVIGMPHR GRLNVLVNIV GKPLATVFTE FEGHIEPKAA GGSGDVKYHL 610 620 630 640 650 660 GAEGTHIQMF GDNEIKVSLA ANPSHLEAVD PVMEGIARAK QDLLNKGDST DGYSVVPMML 670 680 690 700 710 720 HGDAAFAGLG IVQETLNLAQ LRGYTVGGTI HIIVNNQIGF TTTPDSGRSS HYATDLAKAY 730 740 750 760 770 780 GCPVFHVNGD DPEAVVWVGR LATEYRRQFG KDVFIDMISY RRRGHNEADD PSMTQPEMYK 790 800 810 820 830 840 LIDARNTVRE QYKEDLLGRG ELTTEDAEKV QRDFHDQMES IFNDVKETEK KPFEAQAGIT 850 860 870 880 890 900 SSQEVPHGLE TNITREELVE IGQAYATAPE NFEFHQRVAP VAKKRLEAAQ NGGIDWGWGE 910 920 930 940 950 960 LIAFGSLAAG GKFVRLAGED SRRGTFTQRH AVVYDPRTGE EFNGLNDLAE RKGNGGKFLV 970 980 990 1000 1010 1020 YNSALTEYAG MGFEYGYSVG NEDAVVAWEA QFGDFANGAQ TIIDEYISSG EAKWGQTSSV 1030 1040 1050 1060 1070 1080 ILLLPHGYEG QGPDHSSARI ERYLQLCAEG TMTVAQPTTP ANYFHLLRRH VLGGLKRPLV 1090 1100 1110 1120 1130 1140 VFTPKSMLRM KAATSSVEDF TQMKKFQSVI NDPRFVNGGL DKNKVKKIML VSGKLYYDLA 1150 1160 1170 1180 1190 1200 KRAQKDKRDD VAIVRIEMLH PIPFNRLKEA FDFYPNAEEI RFCQDEPANQ GPWPFMHEHL 1210 1220 1230 1240 PELIPGMLPM KRVSRRAQAS TATGLSKVHA VEQQHLLDEA FAD

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248356 Genomic DNA. Translation: CAE49520.1.
RefSeq	NP_939364.2. NC_002935.2.
3D structure databases
ProteinModelPortal	Q6NHX8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2650653.
GenomeReviews	Gene locus DIP1002 in contig BX248353_GR.
KEGG	cdi:DIP1002.
NMPDR	fig|257309.1.peg.955.
PATRIC	21483179. VBICorDip47633_0983.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG289950.
OMA	EGDEPAF.
PhylomeDB	Q6NHX8.
ProtClustDB	PRK12270.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KO	K00164.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6NHX8_CORDI

Accession

Primary (citable) accession number: Q6NHX8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)