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Q6NHU6 (SYR_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:DIP1034
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242009

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q6NHU6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8B8E8A2197E6E0D7

FASTA55059,840
        10         20         30         40         50         60 
MTPADLSQLI KQTAIDVLSA RELDTTVLPE TVVVERPRNP EHGDYATNVA LQIAKKVGMN 

        70         80         90        100        110        120 
PRELGQVLAD SLAANTAIDE ASIAGPGFIN IRLAAAAQGE IVAKILEAGA TFGHSDLYQG 

       130        140        150        160        170        180 
RRVNLEFVSA NPTGPIHLGG TRWAAVGDSL GRVLEASGAQ VTREYYFNDH GRQIDRFTNS 

       190        200        210        220        230        240 
LVASAKGEPT PEDGYGGDYI KEIADAVVAQ HPDVLALAEA DLNERFRATG VEMMFAHIKE 

       250        260        270        280        290        300 
SLHEFGTDFD VYFHENSLFE SGAVDKAIQT LKDNGNLYFN EGAWWLKSSE YGDDKDRVVI 

       310        320        330        340        350        360 
KSDGDAAYIA GDIAYVADKF DRGHDLCIYM LGADHHGYIS RLRAAAAAMG YEPSNVEVLI 

       370        380        390        400        410        420 
GQMVNLVRDG KAVRMSKRAG TVITLDDLVE AIGIDGARYS MIRSSVDSSL DIDLQLWEQQ 

       430        440        450        460        470        480 
SSDNPVYYVQ YGHARLCSIA RKAADLGITA IDPDLSLLTH DREGDLIRTL GEFPAVVKAA 

       490        500        510        520        530        540 
AELREPHRIA RFAEDLAGTF HRFYDSCQIL PKVGESAEPI HTARLALANA TRQVLANALR 

       550 
LVGVSAPERM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248356 Genomic DNA. Translation: CAE49555.1.
RefSeqNP_939396.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NHU6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP1034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE49555; CAE49555; DIP1034.
GeneID2648619.
KEGGcdi:DIP1034.
PATRIC21483247. VBICorDip47633_1016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAQQEVFRS.
OrthoDBEOG6JB13C.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_CORDI
AccessionPrimary (citable) accession number: Q6NHU6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries