Q6NHU6 (SYR_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	DIP1034

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000242009
Regions
	Motif	130 – 140	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q6NHU6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8B8E8A2197E6E0D7	FASTA	550	59,840
	10 20 30 40 50 60 MTPADLSQLI KQTAIDVLSA RELDTTVLPE TVVVERPRNP EHGDYATNVA LQIAKKVGMN 70 80 90 100 110 120 PRELGQVLAD SLAANTAIDE ASIAGPGFIN IRLAAAAQGE IVAKILEAGA TFGHSDLYQG 130 140 150 160 170 180 RRVNLEFVSA NPTGPIHLGG TRWAAVGDSL GRVLEASGAQ VTREYYFNDH GRQIDRFTNS 190 200 210 220 230 240 LVASAKGEPT PEDGYGGDYI KEIADAVVAQ HPDVLALAEA DLNERFRATG VEMMFAHIKE 250 260 270 280 290 300 SLHEFGTDFD VYFHENSLFE SGAVDKAIQT LKDNGNLYFN EGAWWLKSSE YGDDKDRVVI 310 320 330 340 350 360 KSDGDAAYIA GDIAYVADKF DRGHDLCIYM LGADHHGYIS RLRAAAAAMG YEPSNVEVLI 370 380 390 400 410 420 GQMVNLVRDG KAVRMSKRAG TVITLDDLVE AIGIDGARYS MIRSSVDSSL DIDLQLWEQQ 430 440 450 460 470 480 SSDNPVYYVQ YGHARLCSIA RKAADLGITA IDPDLSLLTH DREGDLIRTL GEFPAVVKAA 490 500 510 520 530 540 AELREPHRIA RFAEDLAGTF HRFYDSCQIL PKVGESAEPI HTARLALANA TRQVLANALR 550 LVGVSAPERM

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248356 Genomic DNA. Translation: CAE49555.1.
RefSeq	NP_939396.1. NC_002935.2.
3D structure databases
ProteinModelPortal	Q6NHU6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2648619.
GenomeReviews	Gene locus DIP1034 in contig BX248353_GR.
KEGG	cdi:DIP1034.
NMPDR	fig|257309.1.peg.987.
PATRIC	21483247. VBICorDip47633_1016.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FDVYFHE.
PhylomeDB	Q6NHU6.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP1034-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_CORDI

Accession

Primary (citable) accession number: Q6NHU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program