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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:DIP1115
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195471 – 497Glutamate--tRNA ligaseAdd BLAST497

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NHM1
SMRiQ6NHM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 23"HIGH" regionUniRule annotationAdd BLAST11
Motifi257 – 261"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NHM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIMSDVRVR FCPSPTGTPH VGMVRTALFN WAHARHTGGK LIFRIEDTDA
60 70 80 90 100
ARDSEESYQA IIDSLKWLGM DWDEGVIVGG PHEPYRQSQR MDIYKDVLEK
110 120 130 140 150
LKEAGFVYPA YSTAQEVEER HKAAGRDPKL GYDNYDRTLT DEQIAAFEAE
160 170 180 190 200
GRQPVWRLRM PERDWKWNDL VRGEIEFKSS TQPDYVVARS NGAPLYTLVN
210 220 230 240 250
PVDDALMGIT HVLRGEDLLP STPRQLALYE ALKVIGVAQQ TPEFGHLPFV
260 270 280 290 300
MGEGNKKLSK RDPQSNLFNH RDAGIIPEGM LNYLALLGWS LAGEKDIFSV
310 320 330 340 350
DELVENFDVT NVLANPARFD QKKLEAINAD HIRLLEPKDF EQRLRAYLTE
360 370 380 390 400
YTDFPTDYPA EKFAIAAELV QTRIKMLGDA YGLLSFLAIA DEDLTLDEKS
410 420 430 440 450
AKKNLKETAI PALDAGIAAL EGVEEWTTPA IEAALHKALI EDLDLKPRVA
460 470 480 490
FGALRVGISG QAVSPPLFES MELLGKESTL TRLRATREVT PYQVAAE
Length:497
Mass (Da):55,744
Last modified:July 5, 2004 - v1
Checksum:iB13C2F52CF212B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248357 Genomic DNA Translation: CAE49635.1

Genome annotation databases

EnsemblBacteriaiCAE49635; CAE49635; DIP1115
KEGGicdi:DIP1115

Similar proteinsi

Entry informationi

Entry nameiSYE_CORDI
AccessioniPrimary (citable) accession number: Q6NHM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health