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Q6NHK6 (DDL_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:DIP1131
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341085

Regions

Domain156 – 360205ATP-grasp
Nucleotide binding183 – 23856ATP By similarity

Sites

Metal binding3151Magnesium or manganese 1 By similarity
Metal binding3271Magnesium or manganese 1 By similarity
Metal binding3271Magnesium or manganese 2 By similarity
Metal binding3291Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NHK6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3D651F6AADFD29CC

FASTA36539,428
        10         20         30         40         50         60 
MSQNLSAQNS SETPRIKVAI IYGGRSSEHS VSCVSAGAIM AHLDPQRYEV FPVGITHDGV 

        70         80         90        100        110        120 
WTVGESDPSR LKTVDRVMPE VQFTREVSLS VNPTTAGELC FEDGSLYAKV DVVFPVLHGR 

       130        140        150        160        170        180 
FGEDGTIQGL FELSGVPYVG TGVLSSACGM DKEFTKKLMA AEGLPVGKEV ILRGSETLTE 

       190        200        210        220        230        240 
EHKRELGLPV FVKPARGGSS IGISRVADWS EWDAALSLAR EHDSKVIVEA EIVGVEVECG 

       250        260        270        280        290        300 
VLERIDGSLM ASVPAQLQDT DEGDEGFYGF DTKYLDDVVT AHIPAPFDAE TTALIQELSL 

       310        320        330        340        350        360 
KAFTALSCRG LARVDFFVTD HGPVLNEINT MPGFTPISMY PQVFEATGIG YAQLLDNLIE 


QALHK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248357 Genomic DNA. Translation: CAE49651.1.
RefSeqNP_939488.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NHK6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP1131.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE49651; CAE49651; DIP1131.
GeneID2649933.
KEGGcdi:DIP1131.
PATRIC21483447. VBICorDip47633_1113.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_CORDI
AccessionPrimary (citable) accession number: Q6NHK6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways