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Q6NHF7

- NADK_CORDI

UniProt

Q6NHF7 - NADK_CORDI

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Protein

NAD kinase

Gene

nadK

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821Proton acceptorUniRule annotation
Binding sitei87 – 871NADUniRule annotation
Binding sitei187 – 1871NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 832NADUniRule annotation
Nucleotide bindingi157 – 1582NADUniRule annotation
Nucleotide bindingi198 – 2036NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:DIP1181
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317NAD kinasePRO_0000229626Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1181.

Structurei

3D structure databases

ProteinModelPortaliQ6NHF7.
SMRiQ6NHF7. Positions 8-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NHF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIDCHEDRR VLLVPHTGRP QNVASAALAA ELLDDSGVGV RVLVPAEDTT
60 70 80 90 100
VATHPVLGQF ERVSHSPQAT QSVDLVLVLG GDGTFLRAAD LAHGADLPVL
110 120 130 140 150
GINLGHVGFL AEWEKDSLDE AVRRVTKGSF RIEERMTLDV SVYDSNGTAI
160 170 180 190 200
GRGWALNEVS IENSNRSGVL DATLEIDSRP VSSFGCDGII VSTPTGSTAY
210 220 230 240 250
AFSAGGPVLW PELDAILVVP NNAHALFTKP LVVSPRSSVA VESHPSAFPA
260 270 280 290 300
TAVMDGFRSI SVPPGARVEV KRGSRSIKWV RLDDIPFTDR LVTKLRLPVE
310
GWRGPKNMIP QINPHSA
Length:317
Mass (Da):33,896
Last modified:July 5, 2004 - v1
Checksum:iAA026658AE55C508
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248357 Genomic DNA. Translation: CAE49705.1.
RefSeqiNP_939538.1. NC_002935.2.
WP_010934867.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE49705; CAE49705; DIP1181.
GeneIDi2649736.
KEGGicdi:DIP1181.
PATRICi21483559. VBICorDip47633_1165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248357 Genomic DNA. Translation: CAE49705.1 .
RefSeqi NP_939538.1. NC_002935.2.
WP_010934867.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NHF7.
SMRi Q6NHF7. Positions 8-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1181.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE49705 ; CAE49705 ; DIP1181 .
GeneIDi 2649736.
KEGGi cdi:DIP1181.
PATRICi 21483559. VBICorDip47633_1165.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiNADK_CORDI
AccessioniPrimary (citable) accession number: Q6NHF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3