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Q6NHF7

- NADK_CORDI

UniProt

Q6NHF7 - NADK_CORDI

Protein

NAD kinase

Gene

nadK

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei82 – 821Proton acceptorUniRule annotation
    Binding sitei87 – 871NADUniRule annotation
    Binding sitei187 – 1871NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 832NADUniRule annotation
    Nucleotide bindingi157 – 1582NADUniRule annotation
    Nucleotide bindingi198 – 2036NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:DIP1181
    OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
    Taxonomic identifieri257309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002198: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317NAD kinasePRO_0000229626Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257309.DIP1181.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NHF7.
    SMRiQ6NHF7. Positions 8-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227223.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6NHF7-1 [UniParc]FASTAAdd to Basket

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    MTIDCHEDRR VLLVPHTGRP QNVASAALAA ELLDDSGVGV RVLVPAEDTT    50
    VATHPVLGQF ERVSHSPQAT QSVDLVLVLG GDGTFLRAAD LAHGADLPVL 100
    GINLGHVGFL AEWEKDSLDE AVRRVTKGSF RIEERMTLDV SVYDSNGTAI 150
    GRGWALNEVS IENSNRSGVL DATLEIDSRP VSSFGCDGII VSTPTGSTAY 200
    AFSAGGPVLW PELDAILVVP NNAHALFTKP LVVSPRSSVA VESHPSAFPA 250
    TAVMDGFRSI SVPPGARVEV KRGSRSIKWV RLDDIPFTDR LVTKLRLPVE 300
    GWRGPKNMIP QINPHSA 317
    Length:317
    Mass (Da):33,896
    Last modified:July 5, 2004 - v1
    Checksum:iAA026658AE55C508
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248357 Genomic DNA. Translation: CAE49705.1.
    RefSeqiNP_939538.1. NC_002935.2.
    WP_010934867.1. NC_002935.2.

    Genome annotation databases

    EnsemblBacteriaiCAE49705; CAE49705; DIP1181.
    GeneIDi2649736.
    KEGGicdi:DIP1181.
    PATRICi21483559. VBICorDip47633_1165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248357 Genomic DNA. Translation: CAE49705.1 .
    RefSeqi NP_939538.1. NC_002935.2.
    WP_010934867.1. NC_002935.2.

    3D structure databases

    ProteinModelPortali Q6NHF7.
    SMRi Q6NHF7. Positions 8-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257309.DIP1181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE49705 ; CAE49705 ; DIP1181 .
    GeneIDi 2649736.
    KEGGi cdi:DIP1181.
    PATRICi 21483559. VBICorDip47633_1165.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227223.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

    Entry informationi

    Entry nameiNADK_CORDI
    AccessioniPrimary (citable) accession number: Q6NHF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3