Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6NH87 (FTHS_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:DIP1253
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199342

Regions

Nucleotide binding62 – 698ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NH87 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 27D7F2392BABA05D

FASTA55058,098
        10         20         30         40         50         60 
MPTDVEIAQA HTLEPITDIA NRAGVPSDAL IPYGFTKAKI DINRIASENT GKLVLVTGIS 

        70         80         90        100        110        120 
PTPAGEGKST VLIGLSDAMR LRGHNSIVAI REPSLGPVMG IKGGAAGGGY SQIVPMEDIN 

       130        140        150        160        170        180 
LHFTGDFHAI TAANNTLAAM IDNHIHQGNT LGIDVRRITW QRCLDVNDRC LRKVVTGLGG 

       190        200        210        220        230        240 
KAHGVPTETG FTITAASEIM AILCLALDLT DLEARLARIV VGQTFSSEPV TVGQLNAQGA 

       250        260        270        280        290        300 
LAALLRDAVN PNLVQTLGGT PALCHGGPFA NIAHGCNSLI ATKTALSLGD VVLTEAGFGS 

       310        320        330        340        350        360 
DLGAEKFFDI KSRVGDLNVA ATVVVATVRS LKYNAGVPKD ELTTENLEAL ASGVVNLERH 

       370        380        390        400        410        420 
VENIRAFGIE PIVALNKFAS DTDAEINQLK AWAETMSVQL IPVEVWAHGG QGALELADAV 

       430        440        450        460        470        480 
AVSMQNQTSH HLYDPELGIE ASLLTIAQKI YGAADVELSK QARQDLAYLQ ENGWDRLPVC 

       490        500        510        520        530        540 
ISKTQYSFSD DPSQLGRPEG HTLHVRNLLP RIGAGFIVAL TGDVMTMPGL PKKPAAENIG 

       550 
VENGEIKGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248357 Genomic DNA. Translation: CAE49782.1.
RefSeqNP_939608.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NH87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP1253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE49782; CAE49782; DIP1253.
GeneID2649808.
KEGGcdi:DIP1253.
PATRIC21483701. VBICorDip47633_1235.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CORDI
AccessionPrimary (citable) accession number: Q6NH87
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways