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Q6NH87

- FTHS_CORDI

UniProt

Q6NH87 - FTHS_CORDI

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:DIP1253
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Formate--tetrahydrofolate ligasePRO_0000199342Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1253.

Structurei

3D structure databases

ProteinModelPortaliQ6NH87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NH87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTDVEIAQA HTLEPITDIA NRAGVPSDAL IPYGFTKAKI DINRIASENT
60 70 80 90 100
GKLVLVTGIS PTPAGEGKST VLIGLSDAMR LRGHNSIVAI REPSLGPVMG
110 120 130 140 150
IKGGAAGGGY SQIVPMEDIN LHFTGDFHAI TAANNTLAAM IDNHIHQGNT
160 170 180 190 200
LGIDVRRITW QRCLDVNDRC LRKVVTGLGG KAHGVPTETG FTITAASEIM
210 220 230 240 250
AILCLALDLT DLEARLARIV VGQTFSSEPV TVGQLNAQGA LAALLRDAVN
260 270 280 290 300
PNLVQTLGGT PALCHGGPFA NIAHGCNSLI ATKTALSLGD VVLTEAGFGS
310 320 330 340 350
DLGAEKFFDI KSRVGDLNVA ATVVVATVRS LKYNAGVPKD ELTTENLEAL
360 370 380 390 400
ASGVVNLERH VENIRAFGIE PIVALNKFAS DTDAEINQLK AWAETMSVQL
410 420 430 440 450
IPVEVWAHGG QGALELADAV AVSMQNQTSH HLYDPELGIE ASLLTIAQKI
460 470 480 490 500
YGAADVELSK QARQDLAYLQ ENGWDRLPVC ISKTQYSFSD DPSQLGRPEG
510 520 530 540 550
HTLHVRNLLP RIGAGFIVAL TGDVMTMPGL PKKPAAENIG VENGEIKGLF
Length:550
Mass (Da):58,098
Last modified:July 5, 2004 - v1
Checksum:i27D7F2392BABA05D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248357 Genomic DNA. Translation: CAE49782.1.
RefSeqiNP_939608.1. NC_002935.2.
WP_010934929.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE49782; CAE49782; DIP1253.
GeneIDi2649808.
KEGGicdi:DIP1253.
PATRICi21483701. VBICorDip47633_1235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248357 Genomic DNA. Translation: CAE49782.1 .
RefSeqi NP_939608.1. NC_002935.2.
WP_010934929.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NH87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE49782 ; CAE49782 ; DIP1253 .
GeneIDi 2649808.
KEGGi cdi:DIP1253.
PATRICi 21483701. VBICorDip47633_1235.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiFTHS_CORDI
AccessioniPrimary (citable) accession number: Q6NH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3