Reviewed, UniProtKB/Swiss-Prot Q6NGT4 (AHPD_CORDI)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	DIP1419

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359484
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6NGT4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 687A60DDFFBFA1A1	FASTA	174	18,814
	10 20 30 40 50 60 MSLDNLKSGL PEYAKDLKLN LGSLARSTEL TEQQLWGTFL AVAAATRNEA VFSEISEEAS 70 80 90 100 110 120 EHLSEEAINA ALGAASIMAM NNVAYRAKGW LGDDYAQVKM GLRMNIIAKP GVDKVDFELW 130 140 150 160 170 SLAVSTVNGC EHCTIAHEKT VRSEGLTKEQ IFEAVKIAAT LQGVAQAIEI EASR

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248358 Genomic DNA. Translation: CAE49950.1.
RefSeq	NP_939771.1.
3D structure databases
HSSP	HSSP built from PDB template 1KNC based on UniProtKB P0A5N4.
SMR	Q6NGT4. Positions 6-172.
ModBase	Search...
Protein family/group databases
PeroxiBase	4585. CdipAhpD.
Genome annotation databases
GeneID	2649693.
KEGG	cdi:DIP1419.
NMPDR	fig|257309.1.peg.1362.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG414634.
OMA	RAGLRMN.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP1419-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_CORDI

Accession

Primary (citable) accession number: Q6NGT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)