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Q6NGP1

- PNP_CORDI

UniProt

Q6NGP1 - PNP_CORDI

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi545 – 5451MagnesiumUniRule annotation
Metal bindingi551 – 5511MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:DIP1467
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Polyribonucleotide nucleotidyltransferasePRO_0000329607Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1467.

Structurei

3D structure databases

ProteinModelPortaliQ6NGP1.
SMRiQ6NGP1. Positions 21-745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini611 – 67060KHUniRule annotationAdd
BLAST
Domaini682 – 75170S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NGP1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTKPSNVVF NIDEEFGITE AIATIDNGDF GKRTIRFETG QLARQADGSV
60 70 80 90 100
TTYLDDDTML LATTTASNQP REGFDFFPLT VDVEERMYAA GRIPGSFFRR
110 120 130 140 150
EGRPSTEAIL ACRLIDRPLR PTFVKGLRNE VQVVITVLSV NPQDMYDVVA
160 170 180 190 200
INGASAATQL SGLPVSGPVG GVRMALIADD AHPKGQWIAF PTHEQHEQAL
210 220 230 240 250
FELVVAGRIV SKKQGKKTVD DVAIMMVEAG ATEQVVDRVK AGAPAPTESV
260 270 280 290 300
VAEGLEAAKP FIEVLCRAQA GLAERAAKET QEFPLFPPYT DVVYDAVEKK
310 320 330 340 350
VSKKLRSLLT IKSKQDRDEA TNAYMEEIEA DLIAQLGSDD EAAASKAIRA
360 370 380 390 400
AYNAVMKKIV RHMILTEHFR IDGRGVTDIR DLGVEVDLIP RAHGSSLFER
410 420 430 440 450
GETQILGVTT LDMLKMEQQI DSLTPATSKR YIHHYNFPPY STGETGRVGS
460 470 480 490 500
PKRREIGHGA LAERALVPVI PSREEFPYAI RQVSEALGSN GSTSMGSVCA
510 520 530 540 550
STLSLYNAGV PLKAPVAGIA MGLVSDEVDG ETRYVALTDI LGAEDAFGDM
560 570 580 590 600
DFKVAGTRQF ITALQLDTKL DGIPSEVLAQ ALSQANDARN TILDTMAEVI
610 620 630 640 650
ETPDEMSDYA PRITAITVPV NKIGEVIGPK GKTINSITEE TGANISIEED
660 670 680 690 700
GTVYVSAASG AAAEAAIEKI NAIANPQLPK VGERFLGTVV KTTAFGAFVS
710 720 730 740 750
LLPGRDGLVH ISKLGGGKRI EKVEDVVNVG DKLEVEILDI DNRGKISLAP

VKNED
Length:755
Mass (Da):81,266
Last modified:July 5, 2004 - v1
Checksum:iB764F91EA17ADB24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE49995.1.
RefSeqiNP_939815.1. NC_002935.2.
WP_010935086.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE49995; CAE49995; DIP1467.
GeneIDi2650352.
KEGGicdi:DIP1467.
PATRICi21484142. VBICorDip47633_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE49995.1 .
RefSeqi NP_939815.1. NC_002935.2.
WP_010935086.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NGP1.
SMRi Q6NGP1. Positions 21-745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE49995 ; CAE49995 ; DIP1467 .
GeneIDi 2650352.
KEGGi cdi:DIP1467.
PATRICi 21484142. VBICorDip47633_1447.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiPNP_CORDI
AccessioniPrimary (citable) accession number: Q6NGP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3