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Q6NGP1

- PNP_CORDI

UniProt

Q6NGP1 - PNP_CORDI

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, DIP1467
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi545 – 5451Magnesium By similarity
Metal bindingi551 – 5511Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:DIP1467
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329607Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1467.

Structurei

3D structure databases

ProteinModelPortaliQ6NGP1.
SMRiQ6NGP1. Positions 21-745.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini611 – 67060KHAdd
BLAST
Domaini682 – 75170S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NGP1-1 [UniParc]FASTAAdd to Basket

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MSTKPSNVVF NIDEEFGITE AIATIDNGDF GKRTIRFETG QLARQADGSV    50
TTYLDDDTML LATTTASNQP REGFDFFPLT VDVEERMYAA GRIPGSFFRR 100
EGRPSTEAIL ACRLIDRPLR PTFVKGLRNE VQVVITVLSV NPQDMYDVVA 150
INGASAATQL SGLPVSGPVG GVRMALIADD AHPKGQWIAF PTHEQHEQAL 200
FELVVAGRIV SKKQGKKTVD DVAIMMVEAG ATEQVVDRVK AGAPAPTESV 250
VAEGLEAAKP FIEVLCRAQA GLAERAAKET QEFPLFPPYT DVVYDAVEKK 300
VSKKLRSLLT IKSKQDRDEA TNAYMEEIEA DLIAQLGSDD EAAASKAIRA 350
AYNAVMKKIV RHMILTEHFR IDGRGVTDIR DLGVEVDLIP RAHGSSLFER 400
GETQILGVTT LDMLKMEQQI DSLTPATSKR YIHHYNFPPY STGETGRVGS 450
PKRREIGHGA LAERALVPVI PSREEFPYAI RQVSEALGSN GSTSMGSVCA 500
STLSLYNAGV PLKAPVAGIA MGLVSDEVDG ETRYVALTDI LGAEDAFGDM 550
DFKVAGTRQF ITALQLDTKL DGIPSEVLAQ ALSQANDARN TILDTMAEVI 600
ETPDEMSDYA PRITAITVPV NKIGEVIGPK GKTINSITEE TGANISIEED 650
GTVYVSAASG AAAEAAIEKI NAIANPQLPK VGERFLGTVV KTTAFGAFVS 700
LLPGRDGLVH ISKLGGGKRI EKVEDVVNVG DKLEVEILDI DNRGKISLAP 750
VKNED 755
Length:755
Mass (Da):81,266
Last modified:July 5, 2004 - v1
Checksum:iB764F91EA17ADB24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE49995.1.
RefSeqiNP_939815.1. NC_002935.2.
WP_010935086.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE49995; CAE49995; DIP1467.
GeneIDi2650352.
KEGGicdi:DIP1467.
PATRICi21484142. VBICorDip47633_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE49995.1 .
RefSeqi NP_939815.1. NC_002935.2.
WP_010935086.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NGP1.
SMRi Q6NGP1. Positions 21-745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE49995 ; CAE49995 ; DIP1467 .
GeneIDi 2650352.
KEGGi cdi:DIP1467.
PATRICi 21484142. VBICorDip47633_1447.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiPNP_CORDI
AccessioniPrimary (citable) accession number: Q6NGP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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