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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:DIP1492
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003254931 – 499Probable malate:quinone oxidoreductaseAdd BLAST499

Structurei

3D structure databases

ProteinModelPortaliQ6NGL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NGL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSTTAQHV TDEVDVALIG AGIMSATLGA MLRTLEPGWT QVMFERLDAP
60 70 80 90 100
AQESSSPWNN AGTGHSALCE LNYTPEVKGR VQIDKALGVN EKFQISRQFW
110 120 130 140 150
SYQVNEGVLP SPREWINPVP HVSFGRGEDQ VAYLKKRYEA LAAHPLFPNM
160 170 180 190 200
QYTDDRAKFA EMLPLMADGR SEFEKVAISW TDAGTDINYG SQTRQFLKAA
210 220 230 240 250
EKNGTEIRYG HEVKDIKRDG AKWRVTVKNV HTGDTQVIRA NFVFVGAGGM
260 270 280 290 300
ALPLLQKTGI VEIRGWGGFP VSGQWLRCTN PDIIEQHAAK VYGKASIGAP
310 320 330 340 350
PMSVPHLDTR VIDGEKGLLF GPYAGWTPKF LKKGSYLDLF KSIRPTNLMS
360 370 380 390 400
YLGVGAQEFG LTKYLITEVM KDQAARMESL REYMPNAKDE DWELVTAGQR
410 420 430 440 450
VQAIQPVVGP RFSTLAFGTS LINSADGSVA GILGASPGAS IAPAAMLELL
460 470 480 490
ERCFGQKMVE WGPTIKDMIP SYGIRLATDQ KLFNEIWDHT QATLQLDKK
Length:499
Mass (Da):55,033
Last modified:July 5, 2004 - v1
Checksum:iA3637D30BFAC4560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248358 Genomic DNA. Translation: CAE50019.1.
RefSeqiWP_010935102.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50019; CAE50019; DIP1492.
GeneIDi2650376.
KEGGicdi:DIP1492.
PATRICi21484192. VBICorDip47633_1472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248358 Genomic DNA. Translation: CAE50019.1.
RefSeqiWP_010935102.1. NC_002935.2.

3D structure databases

ProteinModelPortaliQ6NGL9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi2650376.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE50019; CAE50019; DIP1492.
GeneIDi2650376.
KEGGicdi:DIP1492.
PATRICi21484192. VBICorDip47633_1472.

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO_CORDI
AccessioniPrimary (citable) accession number: Q6NGL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.