Q6NGL9 (MQO_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	DIP1492

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_0000325493

Sequences

	Sequence		Length	Mass (Da)
	Q6NGL9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A3637D30BFAC4560	FASTA	499	55,033
	10 20 30 40 50 60 MADSTTAQHV TDEVDVALIG AGIMSATLGA MLRTLEPGWT QVMFERLDAP AQESSSPWNN 70 80 90 100 110 120 AGTGHSALCE LNYTPEVKGR VQIDKALGVN EKFQISRQFW SYQVNEGVLP SPREWINPVP 130 140 150 160 170 180 HVSFGRGEDQ VAYLKKRYEA LAAHPLFPNM QYTDDRAKFA EMLPLMADGR SEFEKVAISW 190 200 210 220 230 240 TDAGTDINYG SQTRQFLKAA EKNGTEIRYG HEVKDIKRDG AKWRVTVKNV HTGDTQVIRA 250 260 270 280 290 300 NFVFVGAGGM ALPLLQKTGI VEIRGWGGFP VSGQWLRCTN PDIIEQHAAK VYGKASIGAP 310 320 330 340 350 360 PMSVPHLDTR VIDGEKGLLF GPYAGWTPKF LKKGSYLDLF KSIRPTNLMS YLGVGAQEFG 370 380 390 400 410 420 LTKYLITEVM KDQAARMESL REYMPNAKDE DWELVTAGQR VQAIQPVVGP RFSTLAFGTS 430 440 450 460 470 480 LINSADGSVA GILGASPGAS IAPAAMLELL ERCFGQKMVE WGPTIKDMIP SYGIRLATDQ 490 KLFNEIWDHT QATLQLDKK

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248358 Genomic DNA. Translation: CAE50019.1.
RefSeq	NP_939838.1. NC_002935.2.
3D structure databases
ProteinModelPortal	Q6NGL9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2650376.
GenomeReviews	Gene locus DIP1492 in contig BX248353_GR.
KEGG	cdi:DIP1492.
NMPDR	fig|257309.1.peg.1429.
PATRIC	21484192. VBICorDip47633_1472.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG289663.
OMA	KKWVPLM.
PhylomeDB	Q6NGL9.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP1492-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_CORDI

Accession

Primary (citable) accession number: Q6NGL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program