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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:DIP1601
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei120 – 140HelicalUniRule annotationAdd BLAST21
Transmembranei161 – 181HelicalUniRule annotationAdd BLAST21
Transmembranei197 – 217HelicalUniRule annotationAdd BLAST21
Transmembranei238 – 258HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei287 – 307HelicalUniRule annotationAdd BLAST21
Transmembranei341 – 361HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088131 – 366Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST366

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NGC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQIIIAGAV GLLVSIFVTP VLIRRFSAEG LGQEIREDGP KSHLRKRGTP
60 70 80 90 100
TMGGIAILIG ITVAYAVTGI VGQVTGTGGL TASGLLVLGL TLALGGLGFA
110 120 130 140 150
DDFIKLYMGR NLGLNKKAKL IGQLAISLIF GALILLFPNA DGLTPGSSHL
160 170 180 190 200
SFLRDLPTVD LAIGPKAVGI AIFLLFIYIL ISAWSNAVNL TDGLDGLAAG
210 220 230 240 250
STAIVMGTYT VITFWQFRNS CSAGAQPGCY DVRDPLDLAI LAAAGLGACL
260 270 280 290 300
GFLWWNAAPA KIFMGDTGSL ALGGLVAGLS VASRTELLMI IVGALFVLEA
310 320 330 340 350
ASVVIQVAGY RTKKIRIFRM APFHHHFENG GWAETTVVIR FWLIAAVAAL
360
IGASIFYGEW LSLTGV
Length:366
Mass (Da):38,273
Last modified:March 15, 2005 - v2
Checksum:i04095D65D937E102
GO

Sequence cautioni

The sequence CAE50126 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248358 Genomic DNA. Translation: CAE50126.1. Different initiation.
RefSeqiWP_014302125.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50126; CAE50126; DIP1601.
KEGGicdi:DIP1601.

Similar proteinsi

Entry informationi

Entry nameiMRAY_CORDI
AccessioniPrimary (citable) accession number: Q6NGC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: August 30, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families