Q6NGB6 (Q6NGB6_CORDI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

DIP1611

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6NGB6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 71C810695D3F2BB2	FASTA	327	36,277
	10 20 30 40 50 60 MSAQPLPAAY QRTITDVISM PTPGQVPFSV EFMPPRDEAA EERLWKAAEA FHDLGASFVS 70 80 90 100 110 120 VTYGAGGSSR ERTMRVAHKL SRHPLTTLVH LTLVEHTQEE LEEILCTYAS HGLSNLLALR 130 140 150 160 170 180 GDPPGTDPMA PWVPTAGGLD YAKDLIDLVR KTEQTSHFQV GIASFPEGHY RAPSIEADTQ 190 200 210 220 230 240 FTLEKLRAGA EFSITQMFFD VDHYLRLRDR LVKADPEHGS KPIIPGLMPI TSLRSVRRQM 250 260 270 280 290 300 ELAGATLPKA LEKRLLDAAR GDEEAHRGDI RKVGIEVTTE MAQRLISEGI PDIHFMTMNY 310 320 VRATQEVLHN LGMAPAWGTQ QGHDAIR

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248358 Genomic DNA. Translation: CAE50136.1.
RefSeq	NP_939953.1. NC_002935.2.
3D structure databases
HSSP	HSSP built from PDB template 1B5T based on UniProtKB P00394.
ProteinModelPortal	Q6NGB6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2650800.
GenomeReviews	Gene locus DIP1611 in contig BX248353_GR.
KEGG	cdi:DIP1611.
NMPDR	fig|257309.1.peg.1544.
PATRIC	21484430. VBICorDip47633_1591.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	Q6NGB6.
ProtClustDB	CLSK638719.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6NGB6_CORDI

Accession

Primary (citable) accession number: Q6NGB6

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)