Q6NGA0 (COX3_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III

Gene names

Name:	ctaE
Ordered Locus Names:	DIP1627

Organism

Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]

Taxonomic identifier

257309 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium diphtheriae

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Associates with subunits I, II and IV to form cytochrome c oxidase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Cytochrome c oxidase subunit 3		PRO_0000183878
Regions
	Transmembrane	28 – 48	21	Helical; Potential
	Transmembrane	72 – 92	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	142 – 162	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6NGA0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A401B97D0B9740AA	FASTA	205	22,507
	10 20 30 40 50 60 MTSAIGNKDM AAPQRVAALN RPNMVSVGTI VFLSQELMFF AGLFAMYFTS RANGIGNGSW 70 80 90 100 110 120 KEGAHHLNVP YALVITIILI SSSVTAQFGV FAAERGDVFG VRRWFSLTIL LGAIFLVGQA 130 140 150 160 170 180 YEYFHLVEHG MTIQSSVYGS SFFITTGFHA AHVLAGALAF VVVLLRLSKS KFTPAQATAA 190 200 MVVSYYWHFV DVVWIGLFIT IYFIQ

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248358 Genomic DNA. Translation: CAE50152.1.
RefSeq	NP_939969.1. NC_002935.2.
3D structure databases
ProteinModelPortal	Q6NGA0.
ModBase	Search...
Protein-protein interaction databases
STRING	257309.DIP1627.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE50152; CAE50152; DIP1627.
GeneID	2648673.
KEGG	cdi:DIP1627.
PATRIC	21484462. VBICorDip47633_1607.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1845.
HOGENOM	HOG000086399.
KO	K02276.
OMA	GDWPPEP.
ProtClustDB	CLSK2519647.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_CORDI

Accession

Primary (citable) accession number: Q6NGA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program