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Protein

Cytochrome c oxidase subunit 3

Gene

ctaE

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Gene namesi
Name:ctaE
Ordered Locus Names:DIP1627
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Cytochrome c oxidase subunit 3PRO_0000183878Add
BLAST

Interactioni

Subunit structurei

Associates with subunits I, II and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi257309.DIP1627.

Structurei

3D structure databases

ProteinModelPortaliQ6NGA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000086399.
KOiK02276.
OMAiWLANELM.
OrthoDBiEOG6SFPBZ.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NGA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAIGNKDM AAPQRVAALN RPNMVSVGTI VFLSQELMFF AGLFAMYFTS
60 70 80 90 100
RANGIGNGSW KEGAHHLNVP YALVITIILI SSSVTAQFGV FAAERGDVFG
110 120 130 140 150
VRRWFSLTIL LGAIFLVGQA YEYFHLVEHG MTIQSSVYGS SFFITTGFHA
160 170 180 190 200
AHVLAGALAF VVVLLRLSKS KFTPAQATAA MVVSYYWHFV DVVWIGLFIT

IYFIQ
Length:205
Mass (Da):22,507
Last modified:July 5, 2004 - v1
Checksum:iA401B97D0B9740AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248358 Genomic DNA. Translation: CAE50152.1.
RefSeqiNP_939969.1. NC_002935.2.
WP_010935207.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50152; CAE50152; DIP1627.
GeneIDi2648673.
KEGGicdi:DIP1627.
PATRICi21484462. VBICorDip47633_1607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248358 Genomic DNA. Translation: CAE50152.1.
RefSeqiNP_939969.1. NC_002935.2.
WP_010935207.1. NC_002935.2.

3D structure databases

ProteinModelPortaliQ6NGA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257309.DIP1627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE50152; CAE50152; DIP1627.
GeneIDi2648673.
KEGGicdi:DIP1627.
PATRICi21484462. VBICorDip47633_1607.

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000086399.
KOiK02276.
OMAiWLANELM.
OrthoDBiEOG6SFPBZ.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiCOX3_CORDI
AccessioniPrimary (citable) accession number: Q6NGA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.