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Q6NG98

- COX2_CORDI

UniProt

Q6NG98 - COX2_CORDI

Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 2 copper A ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi246 – 2461Copper A1By similarity
    Metal bindingi287 – 2871Copper A1By similarity
    Metal bindingi287 – 2871Copper A2By similarity
    Metal bindingi289 – 2891Copper A2; via carbonyl oxygenBy similarity
    Metal bindingi291 – 2911Copper A1By similarity
    Metal bindingi291 – 2911Copper A2By similarity
    Metal bindingi295 – 2951Copper A2By similarity
    Metal bindingi298 – 2981Copper A1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Oxidase aa(3) subunit 2
    Gene namesi
    Name:ctaC
    Ordered Locus Names:DIP1629
    OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
    Taxonomic identifieri257309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002198: Chromosome

    Subcellular locationi

    Cell membrane PROSITE-ProRule annotation; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828PROSITE-ProRule annotationAdd
    BLAST
    Chaini29 – 362334Cytochrome c oxidase subunit 2PROSITE-ProRule annotationPRO_0000006052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi29 – 291N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi29 – 291S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Subunit structurei

    Associates with subunits I, III and IV to form cytochrome c oxidase.By similarity

    Protein-protein interaction databases

    STRINGi257309.DIP1629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NG98.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000245527.
    KOiK02275.
    OMAiMRELWTW.
    OrthoDBiEOG68SVXT.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6NG98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQQEKRGTV RKALLGSVIG FGGLALAGCD VEAPGGPLGT ALGFGWPKGI    50
    TPEATSMYNF WVWVWVTAWI IGFIMWGLFI YGMFSWSAKR AKKAGKDEFP 100
    RQTQYNIPLE LVLTIVPIII VMALFFFTVQ TQDKVTAMDK DPKVTVDVTG 150
    YQWNWKFGYA KVAGELSPTG SDYVGTDEKR QEAAEKTKFD QGGDNPNPIN 200
    GRSKTDTSYL HFNKIETLGT SEEIPVLVLP SNTPVEFDLA SADVSHAFWV 250
    PEFLFKRDAY NHPEQNKQQR RFQIEKIEKE GAFVGRCAEM CGTYHAMMNF 300
    EIRVVSPEKF AQYLKFRNDN PQATNSDALK SIGEAPYATS THPFNSERAT 350
    RDGANFDDTA AA 362
    Length:362
    Mass (Da):40,467
    Last modified:July 5, 2004 - v1
    Checksum:i6D29F5D33F51312F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248358 Genomic DNA. Translation: CAE50154.1.
    RefSeqiNP_939971.1. NC_002935.2.
    WP_003852218.1. NC_002935.2.

    Genome annotation databases

    EnsemblBacteriaiCAE50154; CAE50154; DIP1629.
    GeneIDi2648675.
    KEGGicdi:DIP1629.
    PATRICi21484466. VBICorDip47633_1609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248358 Genomic DNA. Translation: CAE50154.1 .
    RefSeqi NP_939971.1. NC_002935.2.
    WP_003852218.1. NC_002935.2.

    3D structure databases

    ProteinModelPortali Q6NG98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257309.DIP1629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE50154 ; CAE50154 ; DIP1629 .
    GeneIDi 2648675.
    KEGGi cdi:DIP1629.
    PATRICi 21484466. VBICorDip47633_1609.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000245527.
    KOi K02275.
    OMAi MRELWTW.
    OrthoDBi EOG68SVXT.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

    Entry informationi

    Entry nameiCOX2_CORDI
    AccessioniPrimary (citable) accession number: Q6NG98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3