SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6NG98

- COX2_CORDI

UniProt

Q6NG98 - COX2_CORDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 2

Gene
ctaC, DIP1629
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 2 copper A ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Copper A1 By similarity
Metal bindingi287 – 2871Copper A1 By similarity
Metal bindingi287 – 2871Copper A2 By similarity
Metal bindingi289 – 2891Copper A2; via carbonyl oxygen By similarity
Metal bindingi291 – 2911Copper A1 By similarity
Metal bindingi291 – 2911Copper A2 By similarity
Metal bindingi295 – 2951Copper A2 By similarity
Metal bindingi298 – 2981Copper A1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:DIP1629
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Transmembranei107 – 12721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 By similarityAdd
BLAST
Chaini29 – 362334Cytochrome c oxidase subunit 2 By similarityPRO_0000006052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi29 – 291N-palmitoyl cysteine By similarity
Lipidationi29 – 291S-diacylglycerol cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Associates with subunits I, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi257309.DIP1629.

Structurei

3D structure databases

ProteinModelPortaliQ6NG98.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000245527.
KOiK02275.
OMAiMRELWTW.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NG98-1 [UniParc]FASTAAdd to Basket

« Hide

MEQQEKRGTV RKALLGSVIG FGGLALAGCD VEAPGGPLGT ALGFGWPKGI    50
TPEATSMYNF WVWVWVTAWI IGFIMWGLFI YGMFSWSAKR AKKAGKDEFP 100
RQTQYNIPLE LVLTIVPIII VMALFFFTVQ TQDKVTAMDK DPKVTVDVTG 150
YQWNWKFGYA KVAGELSPTG SDYVGTDEKR QEAAEKTKFD QGGDNPNPIN 200
GRSKTDTSYL HFNKIETLGT SEEIPVLVLP SNTPVEFDLA SADVSHAFWV 250
PEFLFKRDAY NHPEQNKQQR RFQIEKIEKE GAFVGRCAEM CGTYHAMMNF 300
EIRVVSPEKF AQYLKFRNDN PQATNSDALK SIGEAPYATS THPFNSERAT 350
RDGANFDDTA AA 362
Length:362
Mass (Da):40,467
Last modified:July 5, 2004 - v1
Checksum:i6D29F5D33F51312F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE50154.1.
RefSeqiNP_939971.1. NC_002935.2.
WP_003852218.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50154; CAE50154; DIP1629.
GeneIDi2648675.
KEGGicdi:DIP1629.
PATRICi21484466. VBICorDip47633_1609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE50154.1 .
RefSeqi NP_939971.1. NC_002935.2.
WP_003852218.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NG98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50154 ; CAE50154 ; DIP1629 .
GeneIDi 2648675.
KEGGi cdi:DIP1629.
PATRICi 21484466. VBICorDip47633_1609.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000245527.
KOi K02275.
OMAi MRELWTW.
OrthoDBi EOG68SVXT.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiCOX2_CORDI
AccessioniPrimary (citable) accession number: Q6NG98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi