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Q6NG98 (COX2_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Ordered Locus Names:DIP1629
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 2 copper A ions per subunit By similarity.

Subunit structure

Associates with subunits I, III and IV to form cytochrome c oxidase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 By similarity
Chain29 – 362334Cytochrome c oxidase subunit 2 By similarity
PRO_0000006052

Regions

Transmembrane60 – 8021Helical; Potential
Transmembrane107 – 12721Helical; Potential

Sites

Metal binding2461Copper A1 By similarity
Metal binding2871Copper A1 By similarity
Metal binding2871Copper A2 By similarity
Metal binding2891Copper A2; via carbonyl oxygen By similarity
Metal binding2911Copper A1 By similarity
Metal binding2911Copper A2 By similarity
Metal binding2951Copper A2 By similarity
Metal binding2981Copper A1 By similarity

Amino acid modifications

Lipidation291N-palmitoyl cysteine By similarity
Lipidation291S-diacylglycerol cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NG98 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6D29F5D33F51312F

FASTA36240,467
        10         20         30         40         50         60 
MEQQEKRGTV RKALLGSVIG FGGLALAGCD VEAPGGPLGT ALGFGWPKGI TPEATSMYNF 

        70         80         90        100        110        120 
WVWVWVTAWI IGFIMWGLFI YGMFSWSAKR AKKAGKDEFP RQTQYNIPLE LVLTIVPIII 

       130        140        150        160        170        180 
VMALFFFTVQ TQDKVTAMDK DPKVTVDVTG YQWNWKFGYA KVAGELSPTG SDYVGTDEKR 

       190        200        210        220        230        240 
QEAAEKTKFD QGGDNPNPIN GRSKTDTSYL HFNKIETLGT SEEIPVLVLP SNTPVEFDLA 

       250        260        270        280        290        300 
SADVSHAFWV PEFLFKRDAY NHPEQNKQQR RFQIEKIEKE GAFVGRCAEM CGTYHAMMNF 

       310        320        330        340        350        360 
EIRVVSPEKF AQYLKFRNDN PQATNSDALK SIGEAPYATS THPFNSERAT RDGANFDDTA 


AA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248358 Genomic DNA. Translation: CAE50154.1.
RefSeqNP_939971.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NG98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP1629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE50154; CAE50154; DIP1629.
GeneID2648675.
KEGGcdi:DIP1629.
PATRIC21484466. VBICorDip47633_1609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000245527.
KOK02275.
OMAMNFEVRA.
OrthoDBEOG68SVXT.
ProtClustDBCLSK2518737.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CORDI
AccessionPrimary (citable) accession number: Q6NG98
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families