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Q6NG33

- GLMS_CORDI

UniProt

Q6NG33 - GLMS_CORDI

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei620 – 6201For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:DIP1700
    OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
    Taxonomic identifieri257309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002198: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 625624Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135325Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257309.DIP1700.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NG33.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 229228Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini296 – 436141SIS 1UniRule annotationAdd
    BLAST
    Domaini470 – 615146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiCRIPCEV.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6NG33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGFVGR TSVPDRDYFA LDVVLEGLRR LEYRGYDSAG VAVVADGAVS    50
    FRKKAGKVQA LEQELETSPM PQSCLGIGHT RWATHGGPTD ANAHPHVVDG 100
    GKLAVVHNGI IENFAELKSE LLGFGHNFVS ETDTEVAATL LGHIFNNEAN 150
    KDLTRAMQLT CQRLEGAFTL LAIHAETPDR IVAARRNSPL VIGVGEGENF 200
    LGSDVSGFID YTKNAVEMDN DQIVTITADG YHITDFQGNH AEGKPFVVEW 250
    DAQAAEKGGY EFFMEKEIHE QPAAVRDTLM GRFDESGKLT LDELRIDEST 300
    LRSIDKIIVI ACGTAAYAGH VARYAIEHWC RIPTEVELAH EFRYRDPIVN 350
    EKTLVVTLSQ SGETMDTLMA VRHAREQGAK VIAICNTNGS SIPRESDACL 400
    YTHAGPEIAV ASTKAFLAQI TATYLLGLYL AQLRGNMFAD EVNAVLGELR 450
    TIPDKVSAVL DGVEDQVKTL AQDMKDATSV LFLGRHVGFP VALEGALKLK 500
    ELAYLHAEGF AAGELKHGPI ALIEEGQPVF VIVPSPRGRD SLHAKVVSNI 550
    QEVRARGAIT IVIAEEGDDA VEAYANHIIR IPQAPTLMQP LLATVPLQIF 600
    ACGVAAAKGF DVDQPRNLAK SVTVE 625
    Length:625
    Mass (Da):67,666
    Last modified:January 23, 2007 - v3
    Checksum:iC9DBB11871EF9A8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248359 Genomic DNA. Translation: CAE50229.1.
    RefSeqiNP_940038.1. NC_002935.2.
    WP_010935264.1. NC_002935.2.

    Genome annotation databases

    EnsemblBacteriaiCAE50229; CAE50229; DIP1700.
    GeneIDi2650293.
    KEGGicdi:DIP1700.
    PATRICi21484620. VBICorDip47633_1683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248359 Genomic DNA. Translation: CAE50229.1 .
    RefSeqi NP_940038.1. NC_002935.2.
    WP_010935264.1. NC_002935.2.

    3D structure databases

    ProteinModelPortali Q6NG33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257309.DIP1700.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE50229 ; CAE50229 ; DIP1700 .
    GeneIDi 2650293.
    KEGGi cdi:DIP1700.
    PATRICi 21484620. VBICorDip47633_1683.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi CRIPCEV.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

    Entry informationi

    Entry nameiGLMS_CORDI
    AccessioniPrimary (citable) accession number: Q6NG33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3