Reviewed, UniProtKB/Swiss-Prot Q6NFU5 (CLPP1_CORDI)

Names and origin

Protein names

Recommended name:
    ATP-dependent Clp protease proteolytic subunit 1
    EC=3.4.21.92
Alternative name(s):
    Endopeptidase Clp 1

Gene names

Name:	clpP1
Ordered Locus Names:	DIP1791

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444		PRO_0000179541
Sites
	Active site	109	1	By similarity
	Active site	134	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6NFU5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 22B39E98A7BCAE31	FASTA	209	23,150
	10 20 30 40 50 60 MNNNGMQMPQ ARYVLPSFIE QSAYGTKETN PYAKLFEERI IFLGTQVDDT SANDIMAQLL 70 80 90 100 110 120 VLEGLDPDRD ITMYINSPGG SFTSLMAIYD TMQYVRPDVR TVCLGQAASA AAVLLAAGAP 130 140 150 160 170 180 GKRACLPNSR VLIHQPATQG TQGQVSDLEI QAKEIERMRT LMEQTLARHT GRSAEQVRID 190 200 TDRDKILTAE EAVEYGIVDQ VFDYRKLNG

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248359 Genomic DNA. Translation: CAE50321.1.
RefSeq	NP_940129.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S14.009.
Genome annotation databases
GeneID	2649416.
GenomeReviews	Gene locus DIP1791 in contig BX248353_GR.
KEGG	cdi:DIP1791.
NMPDR	fig|257309.1.peg.1720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6NFU5.
OMA	ANEILRM.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP1791-MON.
BRENDA	3.4.21.92. 20483.
Family and domain databases
HAMAP	MF_00444. [Tree]
InterPro	IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP1_CORDI

Accession

Primary (citable) accession number: Q6NFU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)