Reviewed, UniProtKB/Swiss-Prot Q6NFN7 (NTPA_CORDI)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

DIP1850

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Nucleoside-triphosphatase		PRO_0000178157

Sequences

	Sequence		Length	Mass (Da)
	Q6NFN7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6EA838BB675E59BB	FASTA	207	22,032
	10 20 30 40 50 60 MKVLVASNNA KKLGELRTIL ENAGLSSVEV VPLSAIDAYD EPVEDGRTFA DNALIKARAG 70 80 90 100 110 120 AHHSGLITIA DDSGFAVEEL NGMPGVLSAR WSGQHGNDAT NNELVLAQMK HVPEERRHAA 130 140 150 160 170 180 FVSVCALVTP DGDEHIVEGR WEGRMLTAPR GANGFGYDPL FVPAEEDAAG TGRTSAEMSP 190 200 AEKNAISHRG KALQQLVPII AGYSTFF

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248359 Genomic DNA. Translation: CAE50379.1.
RefSeq	NP_940187.1.
3D structure databases
HSSP	HSSP built from PDB template 1K7K based on UniProtKB P52061.
ModBase	Search...
Genome annotation databases
GeneID	2649225.
GenomeReviews	Gene locus DIP1850 in contig BX248353_GR.
KEGG	cdi:DIP1850.
NMPDR	fig|257309.1.peg.1778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6NFN7.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP1850-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CORDI

Accession

Primary (citable) accession number: Q6NFN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	July 22, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)