Reviewed, UniProtKB/Swiss-Prot Q6NFN4 (MURI_CORDI)

Names and origin

Protein names

Recommended name:
    Glutamate racemase
    EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	DIP1853

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Glutamate racemase HAMAP MF_00258		PRO_1000047562

Sequences

	Sequence		Length	Mass (Da)
	Q6NFN4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 32A1F4A6BFEAC37E	FASTA	265	28,097
	10 20 30 40 50 60 MNNAPIGIFD SGVGGLTVAR VIMEQLPNES VIYIGDTANS PYGPKPIAQV RELSLAIGEE 70 80 90 100 110 120 LVRRGCKMIV IACNTATSAA LRDLRERFDV PVLGVILPAV RRAVSTTRNG KIGVIGTEGT 130 140 150 160 170 180 IKSGAYQELF AASPSVEVHA QACPSFVSFV ERGITSGRQI LGVAQGYVEP LQAAGVDTLV 190 200 210 220 230 240 LGCTHYPLLT GVIQLAMGDR VTLVSSAEET AKDVFKTLSM TDMLASEDST PVRTFESTGD 250 260 PVLFAQLAER FLGPHVTNVE KFAGM

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248359 Genomic DNA. Translation: CAE50382.1.
RefSeq	NP_940190.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZUW based on UniProtKB P94556.
SMR	Q6NFN4. Positions 1-262.
ModBase	Search...
Genome annotation databases
GeneID	2649228.
KEGG	cdi:DIP1853.
NMPDR	fig|257309.1.peg.1781.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG645102.
OMA	VITQPCP.
PhylomeDB	Q6NFN4.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP1853-MONOMER.
BRENDA	5.1.1.3. 20483.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
TIGRFAMs	TIGR00067. glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_CORDI

Accession

Primary (citable) accession number: Q6NFN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)