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Q6NFM3

- COX1_CORDI

UniProt

Q6NFM3 - COX1_CORDI

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Protein
Cytochrome c oxidase subunit 1
Gene
ctaD, DIP1864
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand) Inferred
Metal bindingi265 – 2651Copper B Inferred
Metal bindingi269 – 2691Copper B Inferred
Metal bindingi314 – 3141Copper B Inferred
Metal bindingi315 – 3151Copper B Inferred
Metal bindingi398 – 3981Iron (heme A3 axial ligand) Inferred
Metal bindingi400 – 4001Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:DIP1864
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei259 – 27921Helical; Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Reviewed prediction
Add
BLAST
Transmembranei434 – 45421Helical; Reviewed prediction
Add
BLAST
Transmembranei477 – 49721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Cytochrome c oxidase subunit 1
PRO_0000183438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi257309.DIP1864.

Structurei

3D structure databases

ProteinModelPortaliQ6NFM3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiIGANESH.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NFM3-1 [UniParc]FASTAAdd to Basket

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MTAVAPRLEN YAEPTRPAPT GGARKGTLAW KMLTTTDHKL LGMMYIVMSF    50
VWFFVGGLMA LLIRAELFSP GLQFLSNEQF NQLFTLHGTI MLLAFGTPVV 100
WGFSNYILPL QIGAPDVAFP RLNAFGFWIT QIGVVAMLAG FLTPGGAADF 150
GWTMYLPLAD SIHSPGVGGD FWIIGVGATG VGTIASAVNM ITTILCMRAP 200
GMTMFRMPIF CWNIFVASVI VLLIFPLLTA AALGVMYDRK LGGHIYDPGN 250
GGAILWQHLF WFFGHPEVYV LALPFFGIVS EVIPVFARKP MFGYIGLVFA 300
TLSIGMLSMA VWAHHMFVTG AILLPFFSFM TFLISVPTGV KFFNWLGTMW 350
RGHISWETPM TWTMGFLVTF LFGGLTGIML ASPPLDFHIS DTYFVVAHFH 400
YTLFGTVVFA SYAGVYFWFP KMTGRMLDER LGKIHFWITF VGFHGTFLVQ 450
HWVGNEGMPR RYADYLESDG FTTLNQISTV FSFLLGVSVI PFIWNVFKSY 500
RYGEIVTVDD PWGYGNSLEW ATSCPPPRHN FTSLPRIRSE RPAFELHYPH 550
MVERMRREAH IGHH 564
Length:564
Mass (Da):63,291
Last modified:July 5, 2004 - v1
Checksum:i2865A8DB72B3CA6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248359 Genomic DNA. Translation: CAE50393.1.
RefSeqiNP_940201.1. NC_002935.2.
WP_003852637.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50393; CAE50393; DIP1864.
GeneIDi2649239.
KEGGicdi:DIP1864.
PATRICi21484962. VBICorDip47633_1848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248359 Genomic DNA. Translation: CAE50393.1 .
RefSeqi NP_940201.1. NC_002935.2.
WP_003852637.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NFM3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1864.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50393 ; CAE50393 ; DIP1864 .
GeneIDi 2649239.
KEGGi cdi:DIP1864.
PATRICi 21484962. VBICorDip47633_1848.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi IGANESH.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiCOX1_CORDI
AccessioniPrimary (citable) accession number: Q6NFM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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