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Q6NFM0

- Q6NFM0_CORDI

UniProt

Q6NFM0 - Q6NFM0_CORDI

Protein

Ribonucleoside-diphosphate reductase

Gene

nrdE

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    DNA replicationUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
    Gene namesi
    Name:nrdEImported
    Ordered Locus Names:DIP1867Imported
    OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)Imported
    Taxonomic identifieri257309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002198: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi257309.DIP1867.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NFM0.
    SMRiQ6NFM0. Positions 17-704.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000246165.
    KOiK00525.
    OMAiTVVYHAL.
    OrthoDBiEOG6J48HC.

    Family and domain databases

    InterProiIPR013346. NrdE_NrdA.
    IPR026459. RNR_1b_NrdE.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    IPR013554. RNR_N.
    IPR008926. RNR_R1-su_N.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    PF08343. RNR_N. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    SUPFAMiSSF48168. SSF48168. 1 hit.
    TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
    TIGR04170. RNR_1b_NrdE. 1 hit.
    PROSITEiPS00089. RIBORED_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6NFM0-1 [UniParc]FASTAAdd to Basket

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    MNQSMGRHVA EPVSRAEQLD YHALNALLNL YDANGRIQFD KDREAANQFF    50
    LQHVNQNTVF FHDLEEKIEY LVENNYYEPE VLDKYSFAGI KDLFKQAYAH 100
    KFRFKSFLGA YKYYTSYTLK TFDGRRYLER FEDRVCMVAL TLADGSIELA 150
    RNLVDEIMTG RFQPATPTFL NSGKAQRGEP VSCFLLRIED NMESIGRSIN 200
    SALQLSKRGG GVALLLSNLR ESGAPIKKIE NQSSGVIPVM KLLEDSFSYA 250
    NQLGARQGAG AVYLNAHHPD ILNFLDTKRE NADEKIRIKT LSLGIVIPDI 300
    TFELAKRNED MYLFSPYDVE RVYGKPFADI SVTELYADMV EDPRIRKTKI 350
    NARSFFQTIA EIQFESGYPY IMFEDTVNRA NPIEGRINMS NLCSEILQVN 400
    SPSVLNADLT YEHVGEDISC NLGSMNIAMA MDSTDFAKTV ETAIRGLTAV 450
    SEQTSIDSVP SIKKGNDAAH AIGLGQMNLH GYLGREHIFY GSEEGLDFTN 500
    AYFAAVLYQC LRASHKIAAE RGQRFEGFET SDYADGSYFD RFDPADFAPK 550
    TAKVQELFEN STIVVPTAED WEELKQLVMK DGLFNRYLQA VPPTGSISYI 600
    NNSTSSIHPI ASRIEIRKEG KIGRVYYPAP HMDNDNLEYY QDAYEIGFEK 650
    VIDTYAVATK YVDQGLSLTL FFKDNVTTRD INRAQIYAWR KGIKSLYYIR 700
    LRQVALEGTE VEGCVSCML 719
    Length:719
    Mass (Da):81,433
    Last modified:July 5, 2004 - v1
    Checksum:i529704ACDD4B4265
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248359 Genomic DNA. Translation: CAE50396.1.
    RefSeqiNP_940204.1. NC_002935.2.
    WP_010935388.1. NC_002935.2.

    Genome annotation databases

    EnsemblBacteriaiCAE50396; CAE50396; DIP1867.
    GeneIDi2649242.
    KEGGicdi:DIP1867.
    PATRICi21484968. VBICorDip47633_1851.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248359 Genomic DNA. Translation: CAE50396.1 .
    RefSeqi NP_940204.1. NC_002935.2.
    WP_010935388.1. NC_002935.2.

    3D structure databases

    ProteinModelPortali Q6NFM0.
    SMRi Q6NFM0. Positions 17-704.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257309.DIP1867.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE50396 ; CAE50396 ; DIP1867 .
    GeneIDi 2649242.
    KEGGi cdi:DIP1867.
    PATRICi 21484968. VBICorDip47633_1851.

    Phylogenomic databases

    HOGENOMi HOG000246165.
    KOi K00525.
    OMAi TVVYHAL.
    OrthoDBi EOG6J48HC.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    InterProi IPR013346. NrdE_NrdA.
    IPR026459. RNR_1b_NrdE.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    IPR013554. RNR_N.
    IPR008926. RNR_R1-su_N.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    PF08343. RNR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    SUPFAMi SSF48168. SSF48168. 1 hit.
    TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
    TIGR04170. RNR_1b_NrdE. 1 hit.
    PROSITEi PS00089. RIBORED_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700971 / NCTC 13129 / Biotype gravisImported.

    Entry informationi

    Entry nameiQ6NFM0_CORDI
    AccessioniPrimary (citable) accession number: Q6NFM0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3