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Q6NFM0 (Q6NFM0_CORDI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase RuleBase RU003410
EC=1.17.4.1 RuleBase RU003410
Gene names
Name:nrdE EMBL CAE50396.1
Ordered Locus Names:DIP1867
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. RuleBase RU003410

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. RuleBase RU003410

Pathway

Genetic information processing; DNA replication. RuleBase RU003410

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase large chain family. RuleBase RU003410

Sequences

Sequence LengthMass (Da)Tools
Q6NFM0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 529704ACDD4B4265

FASTA71981,433
        10         20         30         40         50         60 
MNQSMGRHVA EPVSRAEQLD YHALNALLNL YDANGRIQFD KDREAANQFF LQHVNQNTVF 

        70         80         90        100        110        120 
FHDLEEKIEY LVENNYYEPE VLDKYSFAGI KDLFKQAYAH KFRFKSFLGA YKYYTSYTLK 

       130        140        150        160        170        180 
TFDGRRYLER FEDRVCMVAL TLADGSIELA RNLVDEIMTG RFQPATPTFL NSGKAQRGEP 

       190        200        210        220        230        240 
VSCFLLRIED NMESIGRSIN SALQLSKRGG GVALLLSNLR ESGAPIKKIE NQSSGVIPVM 

       250        260        270        280        290        300 
KLLEDSFSYA NQLGARQGAG AVYLNAHHPD ILNFLDTKRE NADEKIRIKT LSLGIVIPDI 

       310        320        330        340        350        360 
TFELAKRNED MYLFSPYDVE RVYGKPFADI SVTELYADMV EDPRIRKTKI NARSFFQTIA 

       370        380        390        400        410        420 
EIQFESGYPY IMFEDTVNRA NPIEGRINMS NLCSEILQVN SPSVLNADLT YEHVGEDISC 

       430        440        450        460        470        480 
NLGSMNIAMA MDSTDFAKTV ETAIRGLTAV SEQTSIDSVP SIKKGNDAAH AIGLGQMNLH 

       490        500        510        520        530        540 
GYLGREHIFY GSEEGLDFTN AYFAAVLYQC LRASHKIAAE RGQRFEGFET SDYADGSYFD 

       550        560        570        580        590        600 
RFDPADFAPK TAKVQELFEN STIVVPTAED WEELKQLVMK DGLFNRYLQA VPPTGSISYI 

       610        620        630        640        650        660 
NNSTSSIHPI ASRIEIRKEG KIGRVYYPAP HMDNDNLEYY QDAYEIGFEK VIDTYAVATK 

       670        680        690        700        710 
YVDQGLSLTL FFKDNVTTRD INRAQIYAWR KGIKSLYYIR LRQVALEGTE VEGCVSCML

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248359 Genomic DNA. Translation: CAE50396.1.
RefSeqNP_940204.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NFM0.
SMRQ6NFM0. Positions 17-704.
ModBaseSearch...

Protein-protein interaction databases

STRING257309.DIP1867.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE50396; CAE50396; DIP1867.
GeneID2649242.
KEGGcdi:DIP1867.
PATRIC21484968. VBICorDip47633_1851.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000246165.
KOK00525.
OMAVSRIEIR.
ProtClustDBPRK08188.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

InterProIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
SUPFAMSSF48168. Ribonucleo_red_N. 1 hit.
TIGRFAMsTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6NFM0_CORDI
AccessionPrimary (citable) accession number: Q6NFM0
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info