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Protein

Ribonucleoside-diphosphate reductase

Gene

nrdE

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

DNA replicationUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:nrdEImported
Ordered Locus Names:DIP1867Imported
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)Imported
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1867.

Structurei

3D structure databases

ProteinModelPortaliQ6NFM0.
SMRiQ6NFM0. Positions 17-704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246165.
KOiK00525.
OMAiIYFYTVT.
OrthoDBiEOG6J48HC.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NFM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSMGRHVA EPVSRAEQLD YHALNALLNL YDANGRIQFD KDREAANQFF
60 70 80 90 100
LQHVNQNTVF FHDLEEKIEY LVENNYYEPE VLDKYSFAGI KDLFKQAYAH
110 120 130 140 150
KFRFKSFLGA YKYYTSYTLK TFDGRRYLER FEDRVCMVAL TLADGSIELA
160 170 180 190 200
RNLVDEIMTG RFQPATPTFL NSGKAQRGEP VSCFLLRIED NMESIGRSIN
210 220 230 240 250
SALQLSKRGG GVALLLSNLR ESGAPIKKIE NQSSGVIPVM KLLEDSFSYA
260 270 280 290 300
NQLGARQGAG AVYLNAHHPD ILNFLDTKRE NADEKIRIKT LSLGIVIPDI
310 320 330 340 350
TFELAKRNED MYLFSPYDVE RVYGKPFADI SVTELYADMV EDPRIRKTKI
360 370 380 390 400
NARSFFQTIA EIQFESGYPY IMFEDTVNRA NPIEGRINMS NLCSEILQVN
410 420 430 440 450
SPSVLNADLT YEHVGEDISC NLGSMNIAMA MDSTDFAKTV ETAIRGLTAV
460 470 480 490 500
SEQTSIDSVP SIKKGNDAAH AIGLGQMNLH GYLGREHIFY GSEEGLDFTN
510 520 530 540 550
AYFAAVLYQC LRASHKIAAE RGQRFEGFET SDYADGSYFD RFDPADFAPK
560 570 580 590 600
TAKVQELFEN STIVVPTAED WEELKQLVMK DGLFNRYLQA VPPTGSISYI
610 620 630 640 650
NNSTSSIHPI ASRIEIRKEG KIGRVYYPAP HMDNDNLEYY QDAYEIGFEK
660 670 680 690 700
VIDTYAVATK YVDQGLSLTL FFKDNVTTRD INRAQIYAWR KGIKSLYYIR
710
LRQVALEGTE VEGCVSCML
Length:719
Mass (Da):81,433
Last modified:July 5, 2004 - v1
Checksum:i529704ACDD4B4265
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248359 Genomic DNA. Translation: CAE50396.1.
RefSeqiNP_940204.1. NC_002935.2.
WP_010935388.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50396; CAE50396; DIP1867.
GeneIDi2649242.
KEGGicdi:DIP1867.
PATRICi21484968. VBICorDip47633_1851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248359 Genomic DNA. Translation: CAE50396.1.
RefSeqiNP_940204.1. NC_002935.2.
WP_010935388.1. NC_002935.2.

3D structure databases

ProteinModelPortaliQ6NFM0.
SMRiQ6NFM0. Positions 17-704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257309.DIP1867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE50396; CAE50396; DIP1867.
GeneIDi2649242.
KEGGicdi:DIP1867.
PATRICi21484968. VBICorDip47633_1851.

Phylogenomic databases

HOGENOMiHOG000246165.
KOiK00525.
OMAiIYFYTVT.
OrthoDBiEOG6J48HC.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravisImported.

Entry informationi

Entry nameiQ6NFM0_CORDI
AccessioniPrimary (citable) accession number: Q6NFM0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.