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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Desacetylmycothiol; via amide nitrogenUniRule annotation
Binding sitei180 – 1801DesacetylmycothiolUniRule annotation
Binding sitei221 – 2211DesacetylmycothiolUniRule annotation
Binding sitei233 – 2331DesacetylmycothiolUniRule annotation
Binding sitei271 – 2711Desacetylmycothiol; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:DIP1911
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Mycothiol acetyltransferasePRO_0000400248Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NFH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 134129N-acetyltransferase 1UniRule annotationAdd
BLAST
Domaini154 – 303150N-acetyltransferase 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 773Acetyl-CoA binding 1UniRule annotation
Regioni83 – 886Acetyl-CoA binding 1UniRule annotation
Regioni237 – 2393Acetyl-CoA binding 2UniRule annotation
Regioni244 – 2507Acetyl-CoA binding 2UniRule annotation
Regioni276 – 2816Acetyl-CoA binding 2UniRule annotation

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF13508. Acetyltransf_7. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NFH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMIETSLAS ASAALRDRVD EILAAATRED GCAPLSESFL NGLRRADDGH
60 70 80 90 100
VHSCVMDSHD QVVGVAARDG DSAEVVVDPA FRRQGYGSFL IRHVVSQGVK
110 120 130 140 150
NVWAHGDGAG AKAVAKALQL EQTRQLLVMA VEGDRLVESA QLQVPSGFRV
160 170 180 190 200
LALNEAYESI PDIEQQWLRV NNEAFEWHPE QGGWDSARLA QARDTQWFRE
210 220 230 240 250
SDVLFLIDTA KRTVAGFHWT KRHGDLAEGA DGEVYVVGLG SAYRRRGLGD
260 270 280 290 300
LLIRMGLHHL EYEHARRVIL YVEGDNESAR RAYDALGFHV VESHVTYSPQ

SSS
Length:303
Mass (Da):33,488
Last modified:July 5, 2004 - v1
Checksum:i7381E44963AA2C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248359 Genomic DNA. Translation: CAE50445.1.
RefSeqiWP_010935426.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50445; CAE50445; DIP1911.
GeneIDi2648960.
KEGGicdi:DIP1911.
PATRICi21485078. VBICorDip47633_1898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248359 Genomic DNA. Translation: CAE50445.1.
RefSeqiWP_010935426.1. NC_002935.2.

3D structure databases

ProteinModelPortaliQ6NFH9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE50445; CAE50445; DIP1911.
GeneIDi2648960.
KEGGicdi:DIP1911.
PATRICi21485078. VBICorDip47633_1898.

Phylogenomic databases

HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF13508. Acetyltransf_7. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_CORDI
AccessioniPrimary (citable) accession number: Q6NFH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.