Q6NEW7 (DCD_CORDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	DIP2142

Organism

Corynebacterium diphtheriae [Complete proteome] [HAMAP]

Taxonomic identifier

1717 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_1000009711

Sequences

	Sequence		Length	Mass (Da)
	Q6NEW7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BB0A5AFB8F92BF0C	FASTA	187	20,494
	10 20 30 40 50 60 MLYSDKDIRV AIDAGELGIE PFDADLIQPS SIDVRMDRLF RVFNNSKYTH IDPKQQQDEL 70 80 90 100 110 120 TSLVEVPEGE PFVLHPGEFV LGSTLEKFTL PAHIAGRLEG KSSLGRLGLL THSTAGFIDP 130 140 150 160 170 180 GFSGYITLEL SNVANLPITL WPGMKVGQLA LFKMTSPAQA PYGSNVLGSK YQGQRGPTPS KAYLNFR

References

[1]

"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129." Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S. , Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J. Nucleic Acids Res. 31:6516-6523(2003) [PubMed: 14602910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248360 Genomic DNA. Translation: CAE50672.1.
RefSeq	NP_940458.1. NC_002935.2.
3D structure databases
HSSP	HSSP built from PDB template 1XS1 based on UniProtKB P28248.
ProteinModelPortal	Q6NEW7.
SMR	Q6NEW7. Positions 1-186.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2649612.
GenomeReviews	Gene locus DIP2142 in contig BX248353_GR.
KEGG	cdi:DIP2142.
NMPDR	fig|257309.1.peg.2049.
PATRIC	21485583. VBICorDip47633_2146.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553199.
OMA	MEYFRIP.
PhylomeDB	Q6NEW7.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	CDIP257309:DIP2142-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_CORDI

Accession

Primary (citable) accession number: Q6NEW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program