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Q6NET5

- PCKG_CORDI

UniProt

Q6NET5 - PCKG_CORDI

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, pck, DIP2180
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei223 – 2231Substrate; via amide nitrogen By similarity
Metal bindingi230 – 2301Manganese By similarity
Binding sitei230 – 2301Substrate By similarity
Metal bindingi250 – 2501Manganese; via tele nitrogen By similarity
Binding sitei272 – 2721Substrate By similarity
Active sitei274 – 2741 By similarity
Metal bindingi297 – 2971Manganese By similarity
Binding sitei389 – 3891GTP By similarity
Binding sitei420 – 4201GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi273 – 2786GTP By similarity
Nucleotide bindingi514 – 5174GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Synonyms:pck
Ordered Locus Names:DIP2180
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103601Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257309.DIP2180.

Structurei

3D structure databases

ProteinModelPortaliQ6NET5.
SMRiQ6NET5. Positions 13-608.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni387 – 3893Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiIDWHGND.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NET5-1 [UniParc]FASTAAdd to Basket

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MSTVSIKGLE GEAPTKNEVL LNWIAENVEL FQPDRVVFAD GSQEEWDRLT    50
TQLVESGTLI RLNEEKRPNS FLARSNPADV ARVESRTFIC TPTPEGAGPT 100
NHWADPAEMK AELTERFRGS MKGRTMYVVP FCMGPINDPA PKLGVQLTDS 150
EYVVLSMRIM TRMGAEALAK IGDTGSFVPC LHSVGAPLEP GQEDVAWPCN 200
EEKYITHFPE TKEIWSYGSG YGGNAILAKK CYALRIASVM AKEEGWMAEH 250
MLILKLTSPE KKVYYIAAAF PSACGKTNLA MLQPTIDGWS AEVVGDDIAW 300
LRFGEDGRLY AINPENGFFG VAPGTNYSSN PNAMRTMEPG NTLFTNVALT 350
DDGDIWWEDL ENMPEHLTDW LGNDWTPESS QPSSHPNSRY CVPLAQCPVA 400
AEEYNDPQGV PISAILFGGR RPDTVPLVSQ AHNWDHATMI GALLSSGQTA 450
AAEGTVGALR HDPMAMLPFI GYNAADYLQH WIDMGKKGGD KMPEVFLVNW 500
FRRGDDGRFL WPGFGDNSRV LKWIVDRIEG RVEADETIAG YTARVEDLDL 550
TGLDTPIEDI REALSAPAAQ WKSDLADNEE YLTFLGSKGS AVPAEVLEQF 600
EALKARVAAA ES 612
Length:612
Mass (Da):67,353
Last modified:July 5, 2004 - v1
Checksum:iE3E5D0543E74F60E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50707.1.
RefSeqiNP_940490.1. NC_002935.2.
WP_010935642.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50707; CAE50707; DIP2180.
GeneIDi2648926.
KEGGicdi:DIP2180.
PATRICi21485661. VBICorDip47633_2184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50707.1 .
RefSeqi NP_940490.1. NC_002935.2.
WP_010935642.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NET5.
SMRi Q6NET5. Positions 13-608.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257309.DIP2180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50707 ; CAE50707 ; DIP2180 .
GeneIDi 2648926.
KEGGi cdi:DIP2180.
PATRICi 21485661. VBICorDip47633_2184.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi IDWHGND.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiPCKG_CORDI
AccessioniPrimary (citable) accession number: Q6NET5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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