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Q6NET4

- TRMB_CORDI

UniProt

Q6NET4 - TRMB_CORDI

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891S-adenosyl-L-methionineUniRule annotation
Binding sitei114 – 1141S-adenosyl-L-methionineUniRule annotation
Binding sitei141 – 1411S-adenosyl-L-methionineUniRule annotation
Active sitei164 – 1641By similarity
Binding sitei164 – 1641S-adenosyl-L-methionineUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:DIP2181
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259tRNA (guanine-N(7)-)-methyltransferasePRO_0000171322Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP2181.

Structurei

3D structure databases

ProteinModelPortaliQ6NET4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni238 – 2414Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiLHIATDH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NET4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNTDNSDKN TKPTGYRPPQ TDFNTEFGNN LDYPRLGSVS FRRGTLTDNQ
60 70 80 90 100
ESLWDANWPI LGKDLTDAED QRIDVAEWFG RCGHKTILEI GSGTGTSTAA
110 120 130 140 150
MAPLEADTNI IAVELYKPGL AKLLGAVVRG DISNVRMIRG DGVEVLTRML
160 170 180 190 200
PEESLDGVRI YFPDPWPKAR HHKRRIIQSG VLNLIASRLK PGGVLHVATD
210 220 230 240 250
HADYAEWITE LVNVEPQLEF MGWPWDECPQ LTDRQVITKF EGKGLDKDHT

ITEFLWRRK
Length:259
Mass (Da):29,200
Last modified:July 5, 2004 - v1
Checksum:iD4D85C6B0C780F2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50708.1.
RefSeqiNP_940491.1. NC_002935.2.
WP_010935643.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50708; CAE50708; DIP2181.
GeneIDi2648927.
KEGGicdi:DIP2181.
PATRICi21485663. VBICorDip47633_2185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50708.1 .
RefSeqi NP_940491.1. NC_002935.2.
WP_010935643.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NET4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP2181.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50708 ; CAE50708 ; DIP2181 .
GeneIDi 2648927.
KEGGi cdi:DIP2181.
PATRICi 21485663. VBICorDip47633_2185.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi LHIATDH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiTRMB_CORDI
AccessioniPrimary (citable) accession number: Q6NET4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3